Unusual molecular regulation of dorsolateral prefrontal cortex layer III synapses increases vulnerability to genetic and environmental insults in schizophrenia

Age‐related calcium dysregulation linked with tau pathology and impaired cognition in non‐human primates

(2021) Dibyadeep Datta et al.   Alzheimers & Dementia

Subcellular Localization of Schizophrenia Risk Genes Encoding Cav1.2 (CACNA1C) and VIPR2 in Rhesus Macaque Dorsolateral Prefrontal Cortex

(2021) Dibyadeep Datta et al.   BIOLOGICAL PSYCHIATRY

Trial-to-trial variability of spiking delay activity in prefrontal cortex constrains burst-coding models of working memory

(2021) Daming Li et al.   JOURNAL OF NEUROSCIENCE

In vivo evidence of lower synaptic vesicle density in schizophrenia

(2021) Rajiv Radhakrishnan et al.   MOLECULAR PSYCHIATRY

Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance

(2021) Dibyadeep Datta et al.   Frontiers in Aging Neuroscience

The genetics of bipolar disorder

(2020) Francis James A. Gordovez et al.   MOLECULAR PSYCHIATRY

Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex

(2020) Veronica C. Galvin et al.   NEURON

N-Acetylcysteine Inhibits Kynurenine Aminotransferase II

(2020) T. Blanco Ayala et al.   NEUROSCIENCE

Association of Missense Mutation in FOLH1 With Decreased NAAG Levels and Impaired Working Memory Circuitry and Cognition

(2020) Caroline F. Zink et al.   AMERICAN JOURNAL OF PSYCHIATRY

The Evolutionary Expansion of mGluR3-NAAG-GCPII Signaling: Relevance to Human Intelligence and Cognitive Disorders

(2020) Amy F.T. Arnsten et al.   AMERICAN JOURNAL OF PSYCHIATRY

The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex

(2020) Amy F. T. Arnsten et al.   MOLECULAR PSYCHIATRY

Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

(2020) Dibyadeep Datta et al.   Frontiers in Neuroanatomy

A common variation in HCN1 is associated with heart rate variability in schizophrenia

(2020) Alexander Refisch et al.   SCHIZOPHRENIA RESEARCH

Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress

(2019) Melanie Föcking et al.   MOLECULAR PSYCHIATRY

Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia

(2019) Brandon C. McKinney et al.   NEUROPSYCHOPHARMACOLOGY

Noradrenergic α1-Adrenoceptor Actions in the Primate Dorsolateral Prefrontal Cortex

(2019) Dibyadeep Datta et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

(2019) Jochen Kindler et al.   MOLECULAR PSYCHIATRY

Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders

(2019) Arturo Andrade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinct properties of layer 3 pyramidal neurons from prefrontal and parietal areas of the monkey neocortex

(2019) Guillermo Gonzalez-Burgos et al.   JOURNAL OF NEUROSCIENCE

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

(2019) Nicholas C Vierra et al.   eLife

Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study

(2019) Tiffany A. Greenwood et al.   JAMA Psychiatry

Core Differences in Synaptic Signaling Between Primary Visual and Dorsolateral Prefrontal Cortex

(2018) Sheng-Tao Yang et al.   CEREBRAL CORTEX

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients–a pilot study

(2018) Konasale M. Prasad et al.   Translational Psychiatry

Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment

(2017) Y Zhou et al.   MOLECULAR PSYCHIATRY

Cognitive Characterization of Schizophrenia Risk Variants Involved in Synaptic Transmission: Evidence of CACNA1C's Role in Working Memory

(2017) Donna Cosgrove et al.   NEUROPSYCHOPHARMACOLOGY

Kynurenic Acid in Schizophrenia: A Systematic Review and Meta-analysis

(2017) Eric Plitman et al.   SCHIZOPHRENIA BULLETIN

Suppressed Calbindin Levels in Hippocampal Excitatory Neurons Mediate Stress-Induced Memory Loss

(2017) Ji-Tao Li et al.   Cell Reports

Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk

(2017) S M Saini et al.   Translational Psychiatry

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

(2016) Kirsty F. Houslay et al.   BIOCHEMICAL JOURNAL

Presynaptic, release-regulating mGlu2-preferring and mGlu3-preferring autoreceptors in CNS: pharmacological profiles and functional roles in demyelinating disease

(2016) Silvia Di Prisco et al.   BRITISH JOURNAL OF PHARMACOLOGY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain

(2016) Zhi Zhang et al.   NEUROBIOLOGY OF DISEASE

Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia

(2015) Dibyadeep Datta et al.   BIOLOGICAL PSYCHIATRY

Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

(2015) Nao J. Gamo et al.   BIOLOGICAL PSYCHIATRY

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

(2015) Tyrone D. Cannon et al.   BIOLOGICAL PSYCHIATRY

Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic

(2015) T Lencz et al.   MOLECULAR PSYCHIATRY

Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder

(2015) D Arion et al.   MOLECULAR PSYCHIATRY

Stress weakens prefrontal networks: molecular insults to higher cognition

(2015) Amy F T Arnsten   NATURE NEUROSCIENCE

Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophrenia

(2015) R.C. Roberts et al.   SCHIZOPHRENIA RESEARCH

Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology

(2015) Jennifer M. Parrott et al.   Frontiers in Psychiatry

Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response

(2015) William Catterall   Current Molecular Pharmacology

Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

(2014) T Yoshimizu et al.   MOLECULAR PSYCHIATRY

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

REDD1 is essential for stress-induced synaptic loss and depressive behavior

(2014) Kristie T Ota et al.   NATURE MEDICINE

Insights into Human Behavior from Lesions to the Prefrontal Cortex

(2014) Sara M. Szczepanski et al.   NEURON

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex

(2013) Min Wang et al.   NEURON

Nicotinic  7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracortical excitatory and thalamocortical boutons are intact in primary auditory cortex in schizophrenia

(2013) Caitlin E. Moyer et al.   SCHIZOPHRENIA RESEARCH

Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction

(2013) N J Gamo et al.   Translational Psychiatry

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: Facts and challenges

(2012) Edson X. Albuquerque et al.   BIOCHEMICAL PHARMACOLOGY

Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia

(2012) Constantinos D. Paspalas et al.   CEREBRAL CORTEX

Neuromodulation of Thought: Flexibilities and Vulnerabilities in Prefrontal Cortical Network Synapses

(2012) Amy F.T. Arnsten et al.   NEURON

Dendritic spine pathology in schizophrenia

(2012) J.R. Glausier et al.   NEUROSCIENCE

CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease

(2012) Shambhu Bhat et al.   PROGRESS IN NEUROBIOLOGY

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

(2011) Kirsty F. MacKenzie et al.   BIOCHEMICAL JOURNAL

Increased prefrontal cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C]NNC112

(2011) Anissa Abi-Dargham et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

(2011) Vladimir Vacic et al.   NATURE

Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism

(2010) A. Barsegyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of a CACNA1C genotype on attention networks in healthy individuals

(2010) M. Thimm et al.   PSYCHOLOGICAL MEDICINE

Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia

(2010) K. V. Sathyasaikumar et al.   SCHIZOPHRENIA BULLETIN

Differential Expression of Metabotropic Glutamate Receptors 2 and 3 in Schizophrenia: A Mechanism for Antipsychotic Drug Action?

(2009) Subroto Ghose et al.   AMERICAN JOURNAL OF PSYCHIATRY

Stress signalling pathways that impair prefrontal cortex structure and function

(2009) Amy F. T. Arnsten   NATURE REVIEWS NEUROSCIENCE

Interacting noradrenergic and corticosteroid systems shift human brain activation patterns during encoding

(2009) Anda H. van Stegeren et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress

(2009) A. B. Hains et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurexin 1 (NRXN1) Deletions in Schizophrenia

(2009) G. Kirov et al.   SCHIZOPHRENIA BULLETIN

MK2: a novel molecular target for anti-inflammatory therapy

(2008) Senthil Duraisamy et al.   EXPERT OPINION ON THERAPEUTIC TARGETS