Identification of Isthmin1 in the small annual fish, Nothobranchius guentheri, as a novel biomarker of aging and its potential rejuvenation activity

Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

(2021) Zewen Jiang et al.   Cell Metabolism

Zebrafish Ism1 is a novel antiviral factor that positively regulates antiviral immune responses

(2021) Congjun Li et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Effects of Metformin on Life Span, Cognitive Ability, and Inflammatory Response in a Short-Lived Fish

(2020) Juntong Wei et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

hsa_circ_0091570 acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307

(2019) Yu-Gang Wang et al.   CANCER LETTERS

Dietary Intake of β-Glucans Can Prolong Lifespan and Exert an Antioxidant Action of Aged Fish Nothobranchius guentheri

(2019) Lili Song et al.   REJUVENATION RESEARCH

Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri

(2018) Shan Liu et al.   FISH & SHELLFISH IMMUNOLOGY

Isthmin 1 (ism1) is required for normal hematopoiesis in developing zebrafish

(2018) Arturo Berrun et al.   PLoS One

Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fish Nothobranchius guentheri

(2018) Xia Wang et al.   Oncotarget

Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice

(2018) Chieh Kao et al.   EBioMedicine

Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri

(2018) Yang Zhou et al.   BIOGERONTOLOGY

Biological Age Predictors

(2017) Juulia Jylhävä et al.   EBioMedicine

Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii)

(2015) Cheng-Yen Lu et al.   AGE

A systematic review of physical illness, functional disability, and suicidal behaviour among older adults

(2015) Madeleine Mellqvist Fässberg et al.   AGING & MENTAL HEALTH

Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation

(2015) Shruthi Venugopal et al.   CARDIOVASCULAR RESEARCH

Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual FishNothobranchius guentheri

(2015) Tingting Liu et al.   REJUVENATION RESEARCH

Distinct spatiotemporal expression ofISM1during mouse and chick development

(2014) Liliana OSÓRIO et al.   CELL CYCLE

Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction

(2014) M Chen et al.   CELL DEATH AND DIFFERENTIATION

Isthmin 1 Is a Secreted Protein Expressed in Skin, Mucosal Tissues, and NK, NKT, and Th17 Cells

(2014) Ricardo Valle-Rios et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Late-Onset Temperature Reduction Can Retard the Aging Process in Aged Fish Via a Combined Action of an Anti-Oxidant System and the Insulin/Insulin-Like Growth Factor 1 Signaling Pathway

(2014) Xia Wang et al.   REJUVENATION RESEARCH

Effect of Antioxidants Supplementation on Aging and Longevity

(2014) Izabela Sadowska-Bartosz et al.   Biomed Research International

Toxic effects of 1-decyl-3-methylimidazolium bromide ionic liquid on the antioxidant enzyme system and DNA in zebrafish (Danio rerio) livers

(2013) Miao Dong et al.   CHEMOSPHERE

Rejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged rats

(2012) Linlin Lu et al.   AGE

Differential expression of aging biomarkers at different life stages of the annual fish Nothobranchius guentheri

(2012) Changshui Liu et al.   BIOGERONTOLOGY

Potential of telomerase activation in extending health span and longevity

(2012) Bruno Bernardes de Jesus et al.   CURRENT OPINION IN CELL BIOLOGY

Isthmin inhibits glioma growth through antiangiogenesis in vivo

(2012) Bangqing Yuan et al.   JOURNAL OF NEURO-ONCOLOGY

Age-Related Markers Assayed at Different Developmental Stages of the Annual Fish Nothobranchius rachovii

(2011) C.-Y. Hsu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state

(2011) Y Zhang et al.   Cell Death & Disease

Intake of a Milk-Based Wolfberry Formulation Enhances the Immune Response of Young-Adult and Aged Mice

(2010) Karine Vidal et al.   REJUVENATION RESEARCH

Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fishNothobranchius furzeri

(2009) Eva Terzibasi et al.   AGING CELL

A kringle-containing protease with plasminogen-like activity in the basal chordateBranchiostoma belcheri

(2009) Mingying Liu et al.   BIOSCIENCE REPORTS

Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice

(2009) Wei Xiang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research

(2009) Kathrin Reichwald et al.   GENOME BIOLOGY

Responses of alternative complement expression to challenge with different combinations of Vibrio anguillarum, Escherichia coli and Staphylococcus aureus: Evidence for specific immune priming in amphioxus Branchiostoma belcheri

(2008) Guangfeng Wang et al.   FISH & SHELLFISH IMMUNOLOGY