Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system

Microbiome as Mediator of Diet on Colorectal Cancer Risk: The Role of Vitamin D, Markers of Inflammation and Adipokines

(2021) Davide Serrano et al.   Nutrients

Butyrate and the Fine-Tuning of Colonic Homeostasis: Implication for Inflammatory Bowel Diseases

(2021) Naschla Gasaly et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Leaky Gut: Effect of Dietary Fiber and Fats on Microbiome and Intestinal Barrier

(2021) Haruki Usuda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs

(2021) Georg Schett et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptome Profiling and Metagenomic Analysis Help to Elucidate Interactions in an Inflammation-Associated Cancer Mouse Model

(2021) Kazuko Sakai et al.   Cancers

Vitamin D Intake and the Risk of Colorectal Cancer: An Updated Meta-Analysis and Systematic Review of Case-Control and Prospective Cohort Studies

(2021) Hatim Boughanem et al.   Cancers

An update on vitamin D signaling and cancer

(2020) Carsten Carlberg et al.   SEMINARS IN CANCER BIOLOGY

Seasonal changes of circulating 25-hydroxyvitamin D correlate with the lower gut microbiome composition in inflammatory bowel disease patients

(2020) Katarina Soltys et al.   Scientific Reports

Vitamin D receptor promotes healthy microbial metabolites and microbiome

(2020) Ishita Chatterjee et al.   Scientific Reports

Regulation of gut microbiota substantially contributes to the induction of intestinal Treg cells and consequent anti-arthritis effect of madecassoside

(2020) Simiao Qiao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Vitamin D metabolites and the gut microbiome in older men

(2020) Robert L. Thomas et al.   Nature Communications

The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals

(2020) Parul Singh et al.   Scientific Reports

Vitamin D Is Required for ILC3 Derived IL-22 and Protection From Citrobacter rodentium Infection

(2019) Yang-Ding Lin et al.   Frontiers in Immunology

Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials

(2019) N Keum et al.   ANNALS OF ONCOLOGY

Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis

(2019) Margherita T. Cantorna et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer

(2019) Kimmie Ng et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

(2019) Jakob Wirbel et al.   NATURE MEDICINE

Effect of Vitamin D Supplementation on Faecal Microbiota: A Randomised Clinical Trial

(2019) Negar Naderpoor et al.   Nutrients

Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects

(2019) Lucia Malaguarnera   INTERNATIONAL IMMUNOPHARMACOLOGY

Association Between Fusobacterium nucleatum, Pathway Mutation, and Patient Prognosis in Colorectal Cancer

(2018) Dae-Won Lee et al.   ANNALS OF SURGICAL ONCOLOGY

Dietary vitamin D, vitamin D receptor, and microbiome

(2018) Jun Sun   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Progress in characterizing the linkage between Fusobacterium nucleatum and gastrointestinal cancer

(2018) Yang Liu et al.   JOURNAL OF GASTROENTEROLOGY

Vitamin D and the gut microbiome: a systematic review of in vivo studies

(2018) Mary Waterhouse et al.   EUROPEAN JOURNAL OF NUTRITION

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice

(2018) Daniel Triner et al.   GASTROENTEROLOGY

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice

(2017) Sunny H. Wong et al.   GASTROENTEROLOGY

Colorectal Cancer and Dysplasia in Inflammatory Bowel Disease: A Review of Disease Epidemiology, Pathophysiology, and Management

(2016) P. S. Dulai et al.   Cancer Prevention Research

Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc

(2016) Jawad Abed et al.   Cell Host & Microbe

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

Fusobacterium nucleatum-Induced Impairment of Autophagic Flux Enhances the Expression of Proinflammatory Cytokines via ROS in Caco-2 Cells

(2016) Bin Tang et al.   PLoS One

Vitamin D Status Is Associated with Intestinal Inflammation as Measured by Fecal Calprotectin in Crohn’s Disease in Clinical Remission

(2015) Tara Raftery et al.   DIGESTIVE DISEASES AND SCIENCES

Frequent Use of Antibiotics Is Associated with Colorectal Cancer Risk: Results of a Nested Case–Control Study

(2015) Vincent K. Dik et al.   DIGESTIVE DISEASES AND SCIENCES

Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract

(2015) Mina Bashir et al.   EUROPEAN JOURNAL OF NUTRITION

Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

(2015) Chamutal Gur et al.   IMMUNITY

Multiple β-defensin genes are upregulated by the vitamin D pathway in cattle

(2015) Kathryn E. Merriman et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn’s disease: Results from a randomised double-blind placebo-controlled study

(2015) Tara Raftery et al.   United European Gastroenterology Journal

Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer

(2014) S. Meeker et al.   CANCER RESEARCH

Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma

(2014) T. Tahara et al.   CANCER RESEARCH

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials

(2014) E. Theodoratou et al.   BMJ-British Medical Journal

Chronic ulcerative colitis and colorectal cancer

(2013) Gerhard Rogler   CANCER LETTERS

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

Vitamin D for Health: A Global Perspective

(2013) Arash Hossein-nezhad et al.   MAYO CLINIC PROCEEDINGS

Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids

(2013) Chunxiao Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Gut Microbiome Modulates Colon Tumorigenesis

(2013) J. P. Zackular et al.   mBio

MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells

(2012) Silvia Alvarez-Díaz et al.   HUMAN MOLECULAR GENETICS

1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region

(2012) S. W. Kang et al.   JOURNAL OF IMMUNOLOGY

Inflammation and colorectal cancer: colitis-associated neoplasia

(2012) Sergei I. Grivennikov   Seminars in Immunopathology

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

(2011) A. D. Kostic et al.   GENOME RESEARCH

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

Shifting the balance: antibiotic effects on host–microbiota mutualism

(2011) Benjamin P. Willing et al.   NATURE REVIEWS MICROBIOLOGY

Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

(2010) Perry Stambolsky et al.   CANCER CELL

Effects of Supplemental Vitamin D and Calcium on Oxidative DNA Damage Marker in Normal Colorectal Mucosa: A Randomized Clinical Trial

(2010) V. Fedirko et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Fusobacterium nucleatum Outer Membrane Proteins Fap2 and RadD Induce Cell Death in Human Lymphocytes

(2010) C. W. Kaplan et al.   INFECTION AND IMMUNITY

Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma

(2010) Sara Gandini et al.   INTERNATIONAL JOURNAL OF CANCER

Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity

(2010) Diane L. Kamen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Vitamin D, disease and therapeutic opportunities

(2010) Lori A. Plum et al.   NATURE REVIEWS DRUG DISCOVERY

Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D Activity

(2009) P. Protiva et al.   Cancer Prevention Research

The Roles of Antimicrobial Peptides in Innate Host Defense

(2009) Gill Diamond et al.   CURRENT PHARMACEUTICAL DESIGN

Vitamin D receptor deletion leads to reduced level of IκBα protein through protein translation, protein–protein interaction, and post-translational modification

(2009) Shaoping Wu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

(2009) Silvia ρlvarez-Díaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage-derived IL-1β stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3

(2009) P Kaler et al.   ONCOGENE

Antibiotic use predicts an increased risk of cancer

(2008) Annamari Kilkkinen et al.   INTERNATIONAL JOURNAL OF CANCER

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

(2008) Xin Yu et al.   NATURE IMMUNOLOGY

Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity

(2008) John S Adams et al.   Nature clinical practice. Endocrinology & metabolism

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

(2007) Juan Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY