HIV-1 Tat: An update on transcriptional and non-transcriptional functions

The HIV-1 Tat Protein Enhances Splicing at the Major Splice Donor Site

(2018) Nancy Mueller et al.   JOURNAL OF VIROLOGY

HIV latency reversing agents act through Tat post translational modifications

(2018) Georges Khoury et al.   Retrovirology

Tat controls transcriptional persistence of unintegrated HIV genome in primary human macrophages

(2018) Beatrix Meltzer et al.   VIROLOGY

Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells

(2018) Christophe Chopard et al.   Nature Communications

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

(2018) Tyler B Faust et al.   eLife

HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production

(2018) Rawan El-Amine et al.   Redox Biology

HIV-1 Tat-induced bystander apoptosis in Jurkat cells involves unfolded protein responses

(2018) Jéssica Campestrini et al.   CELL BIOCHEMISTRY AND FUNCTION

Cellular RelB interacts with the transactivator Tat and enhance HIV-1 expression

(2018) Meng Wang et al.   Retrovirology

HEXIM1-Tat chimera inhibits HIV-1 replication

(2018) Marie Leoz et al.   PLoS Pathogens

Conformational diversity in the intrinsically disordered HIV-1 Tat protein induced by zinc and pH

(2018) Tomoko Kunihara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIV-1 decreases Nrf2/ARE activity and phagocytic function in alveolar macrophages

(2017) Bashar S. Staitieh et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HIV Tat induces a prolonged MYC relocalization next to IGH in circulating B-cells

(2017) D Germini et al.   LEUKEMIA

The folding competence of HIV-1 Tat mediated by interaction with TAR RNA

(2017) Jung Min Kim et al.   RNA Biology

Tat is a multifunctional viral protein that modulates cellular gene expression and functions

(2017) Evan Clark et al.   Oncotarget

Inhibition of Non Canonical HIV-1 Tat Secretion Through the Cellular Na + ,K + -ATPase Blocks HIV-1 Infection

(2017) Silvia Agostini et al.   EBioMedicine

HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes

(2016) Rémi Planès et al.   JOURNAL OF VIROLOGY

Development of an Attenuated Tat Protein as a Highly-effective Agent to Specifically Activate HIV-1 Latency

(2016) Guannan Geng et al.   MOLECULAR THERAPY

Tat-dependent production of an HIV-1 TAR-encoded miRNA-like small RNA

(2016) Alex Harwig et al.   NUCLEIC ACIDS RESEARCH

HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation

(2016) Anna Lisa Remoli et al.   mBio

Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance

(2016) Dorota Kmiec et al.   mBio

HIV-Tat Protein Forms Phosphoinositide-dependent Membrane Pores Implicated in Unconventional Protein Secretion

(2015) Marcel Zeitler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Rev downregulates Tat expression and viral replication via modulation of NAD(P)H:quinine oxidoreductase 1 (NQO1)

(2015) Sneh Lata et al.   Nature Communications

Structural Disorder in Viral Proteins

(2014) Bin Xue et al.   CHEMICAL REVIEWS

HIV-1 Tat Protein Induces PD-L1 (B7-H1) Expression on Dendritic Cells through Tumor Necrosis Factor Alpha- and Toll-Like Receptor 4-Mediated Mechanisms

(2014) R. Planes et al.   JOURNAL OF VIROLOGY

Life of psi: How full-length HIV-1 RNAs become packaged genomes in the viral particles

(2014) Malika Kuzembayeva et al.   VIROLOGY

The V1/V2 loop of HIV-1 gp120 is necessary for Tat binding and consequent modulation of virus entry

(2013) Sabrina Cardaci et al.   FEBS LETTERS

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein

(2013) T. P. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-α and IL-10

(2013) Nawal Ben Haij et al.   Retrovirology

Induced Degradation of Tat by Nucleocapsid (NC) via the Proteasome Pathway and Its Effect on HIV Transcription

(2013) Hye-Won Hong et al.   Viruses-Basel

Molecular mechanisms in the dramatic enhancement of HIV-1 Tat transduction by cationic liposomes

(2012) Guan-Han Li et al.   FASEB JOURNAL

Protein intrinsic disorder as a flexible armor and a weapon of HIV-1

(2011) Bin Xue et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HIV-1 Tat Protein Promotes Neuronal Dysfunction through Disruption of MicroRNAs

(2011) J. Robert Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RNA annealing mechanism of the HIV-1 Tat peptide: conversion of the RNA into an annealing-competent conformation

(2011) Martina Doetsch et al.   NUCLEIC ACIDS RESEARCH

The Ins and Outs of HIV-1 Tat

(2011) Solène Debaisieux et al.   TRAFFIC

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat

(2010) Lisa Muniz et al.   PLoS Pathogens

Nrf2 is involved in inhibiting Tat-induced HIV-1 long terminal repeat transactivation

(2009) Hong-Sheng Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism for HIV-1 Tat Insertion into the Endosome Membrane

(2009) Hocine Yezid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV Nef Enhances Tat-Mediated Viral Transcription through a hnRNP-K-Nucleated Signaling Complex

(2008) Dietlinde Wolf et al.   Cell Host & Microbe

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

(2008) Sonja Baumli et al.   EMBO JOURNAL