San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia

DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis

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Regulatory R-loops as facilitators of gene expression and genome stability

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ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells

(2019) Veronica Marabitti et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

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R-Loops as Cellular Regulators and Genomic Threats

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Poly(ADP-ribose)-dependent ubiquitination and its clinical implications

(2019) Christina A. Vivelo et al.   BIOCHEMICAL PHARMACOLOGY

Poly(ADP‐ribosyl)ation of BRD7 by PARP1 confers resistance to DNA‐damaging chemotherapeutic agents

(2019) Kaishun Hu et al.   EMBO REPORTS

High-resolution, strand-specific R-loop mapping via S9.6-based DNA–RNA immunoprecipitation and high-throughput sequencing

(2019) Lionel A. Sanz et al.   Nature Protocols

SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer

(2019) Neelum Aziz Yousafzai et al.   Cell Death & Disease

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Arginine methylation of the DDX 5 helicase RGG / RG motif by PRMT 5 regulates resolution of RNA:DNA hybrids

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R Loops: From Physiological to Pathological Roles

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ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

(2019) Dominick A. Matos et al.   MOLECULAR CELL

Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

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Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy

(2018) Annapoorna Kannan et al.   NUCLEIC ACIDS RESEARCH

A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links

(2018) Alex M. Andrews et al.   Nature Communications

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

(2018) Sarah Cohen et al.   Nature Communications

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage

(2018) Agnese Cristini et al.   Cell Reports

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(2018) Sigolène M. Meilhac et al.   Nature Reviews Cardiology

Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development

(2017) Lina Zhou et al.   FASEB JOURNAL

Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration

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Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability

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Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation

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Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals

(2016) Lionel A. Sanz et al.   MOLECULAR CELL

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia

(2016) Nicolas C. Hoch et al.   NATURE

Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation

(2016) Gongshi Bai et al.   PLoS Genetics

XRN2 Links Transcription Termination to DNA Damage and Replication Stress

(2016) Julio C. Morales et al.   PLoS Genetics

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

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(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

(2015) María L. García-Rubio et al.   PLoS Genetics

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

(2014) Bao N. Puente et al.   CELL

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6

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Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes

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R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

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Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

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Cardiomyocyte cell cycle control and growth estimation in vivo—an analysis based on cardiomyocyte nuclei

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The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

(2010) Chen-Hua Chuang et al.   PLoS Genetics

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

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