Structure, Function, and Thermodynamics of Lactate Dehydrogenases from Humans and the Malaria Parasite P. falciparum

Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A

(2020) Anders Friberg et al.   ACS Omega

Natural Selection Shapes Codon Usage in the Human Genome

(2020) Ryan S. Dhindsa et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Inflection Point Hypothesis: The Relationship between the Temperature Dependence of Enzyme-Catalyzed Reaction Rates and Microbial Growth Rates

(2020) Erica J. Prentice et al.   BIOCHEMISTRY

Conformational states dynamically populated by a kinase determine its function

(2020) Tao Xie et al.   SCIENCE

Structural determinants increasing flexibility confer cold adaptation in psychrophilic phosphoglycerate kinase

(2019) David Mandelman et al.   EXTREMOPHILES

Establishment of mesophilic-like catalytic properties in a thermophilic enzyme without affecting its thermal stability

(2019) Satoshi Akanuma et al.   Scientific Reports

The enthalpy-entropy compensation phenomenon. Limitations for the use of some basic thermodynamic equations

(2018) Sergei Khrapunov   CURRENT PROTEIN & PEPTIDE SCIENCE

Forces acting on codon bias in malaria parasites

(2018) I. Sinha et al.   Scientific Reports

Functional and Structural Resilience of the Active Site Loop in the Evolution of Plasmodium Lactate Dehydrogenase

(2018) Jacob D. Wirth et al.   BIOCHEMISTRY

Thermal activation of ‘allosteric-like’ large-scale motions in a eukaryotic Lactate Dehydrogenase

(2017) Marina Katava et al.   Scientific Reports

Substrate Specificity and Allosteric Regulation of a d-Lactate Dehydrogenase from a Unicellular Cyanobacterium are Altered by an Amino Acid Substitution

(2017) Shoki Ito et al.   Scientific Reports

On the Temperature Dependence of Enzyme-Catalyzed Rates

(2016) Vickery L. Arcus et al.   BIOCHEMISTRY

Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

(2016) Alan Merk et al.   CELL

Conformational Heterogeneity in the Michaelis Complex of Lactate Dehydrogenase: An Analysis of Vibrational Spectroscopy Using Markov and Hidden Markov Models

(2016) Xiaoliang Pan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Enzyme surface rigidity tunes the temperature dependence of catalytic rates

(2016) Geir Villy Isaksen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptations of protein structure and function to temperature: there is more than one way to 'skin a cat'

(2015) P. A. Fields et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The Dynamical Nature of Enzymatic Catalysis

(2014) Robert Callender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Investigation of tryptophan–NADH interactions in live human cells using three-photon fluorescence lifetime imaging and Förster resonance energy transfer microscopy

(2013) Vinod Jyothikumar et al.   JOURNAL OF BIOMEDICAL OPTICS

THE DYNAMICS OF RECIPROCAL SELECTIVE SWEEPS OF HOST RESISTANCE AND A PARASITE COUNTER-ADAPTATION INDROSOPHILA

(2012) Lena Wilfert et al.   EVOLUTION

Enthalpy–Entropy Compensation and Cooperativity as Thermodynamic Epiphenomena of Structural Flexibility in Ligand–Receptor Interactions

(2012) Andrea Ferrante et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of Novel Dihydroxynaphthoic Acid Inhibitors of Plasmodium Falciparum Lactate Dehydrogenase

(2012) Eugene Megnassan et al.   Medicinal Chemistry

A new understanding of how temperature affects the catalytic activity of enzymes

(2010) Roy M. Daniel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Malaria Parasite Development in the Mosquito and Infection of the Mammalian Host

(2009) Ahmed S.I. Aly et al.   Annual Review of Microbiology

Probing the Role of Dynamics in Hydride Transfer Catalyzed by Lactate Dehydrogenase

(2008) Nickolay Zhadin et al.   BIOPHYSICAL JOURNAL

Tropical Malaria Does Not Mean Hot Environments

(2008) Takaya Ikemoto   JOURNAL OF MEDICAL ENTOMOLOGY