Article
Neurosciences
Giulia Chiacchierini, Fabien Naneix, Kate Zara Peters, John Apergis-Schoute, Eelke Mirthe Simone Snoeren, James Edgar McCutcheon
Summary: The control of protein intake is crucial for biological processes, and this study shows that in rats, protein restriction can lead to increased preference for protein and heightened VTA responses compared to carbohydrates. Prior protein restriction can also induce long-lasting food preference and VTA responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Yesid R. Garavito-Duarte, Crystal L. Levesque, Kevin Herrick, Jorge Y. Perez-Palencia
Summary: Two experiments were conducted to test the nutritional value of high protein dried distillers with solubles and yeast mass added (GDDY) products for growing pigs. The results showed that GDDY products had comparable amino acid digestibility and metabolizable energy to feeds commonly used in swine diets, indicating that GDDY could be a potential alternative source of protein and energy in swine diets.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Suihua Huang, Quanqing Deng, Yarong Zhao, Guang Chen, Anjing Geng, Xu Wang
Summary: Seed priming with Glu can enhance the tolerance of fragrant rice to arsenite, increase the content of 2-AP and Pro, and regulate the expression of related genes and metabolites involved in amino acid and glutathione metabolism pathways.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Jinyoung Lee, Jolie Caroline Gonzalez-Vega, John Kyaw Htoo, Chengbo Yang, Charles Martin Nyachoti
Summary: This study aimed to investigate the effects of dietary crude protein (CP) contents and crystalline amino acids (CAA) supplementation patterns on growth performance, intestinal histomorphology, and immune response in weaned pigs. The results showed that low CP diets could improve gut health and reduce inflammatory responses, while CAA supplementation patterns had no effect on the outcomes.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Sarah L. Weber, Karin Hustedt, Nadine Schnepel, Christian Visscher, Alexandra S. Muscher-Banse
Summary: This study investigated the effects of protein and/or phosphorus restriction on the GCN2/eIF2 alpha/ATF4 pathway and the induction of FGF21 in the liver of goats. The results demonstrated that dietary N restriction increased the expression of FGF21, while P restriction prevented the initiation of the AAR pathway and the increase in FGF21 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Alessandro Mangogna, Filippo Giorgio Di Girolamo, Nicola Fiotti, Pierandrea Vinci, Matteo Landolfo, Filippo Mearelli, Gianni Biolo
Summary: This study investigated the ability of a high-protein BCAA-enriched diet to prevent insulin resistance during long-term bed rest. The results showed that the high protein-BCAA diet prevented inactivity-induced insulin resistance in healthy women. The diet did not have any significant impact on protein metabolism.
CLINICAL NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Pablo Jesus Marin-Garcia, Luis Rodenas, Eugenio Martinez-Paredes, Vicente Javier Moya, Maria Cambra-Lopez, Enrique Blas, Juan Jose Pascual
Summary: This study compared the effects of two diets on fast-growing rabbits and found that a diet with higher levels of lysine and lower levels of threonine (MHL) improved growth rate and feed conversion ratio, while reducing urea excretion.
Article
Chemistry, Multidisciplinary
James L. Galman, Fabio Parmeggiani, Lisa Seibt, William R. Birmingham, Nicholas J. Turner
Summary: In this study, an enzyme cascade system was constructed by engineering enzymes and cell strains, which could produce high-value chemicals from lignin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Food Science & Technology
Lina Traksele, Vilma Speiciene, Romualdas Smicius, Gitana Alencikiene, Alvija Salaseviciene, Galina Garmiene, Vilma Zigmantaite, Ramune Grigaleviciute, Audrius Kucinskas
Summary: The research found that defatted black soldier fly larvae biomass had higher protein digestibility and can serve as a highly bioavailable protein source for human nutrition. The in vivo and in vitro digestibility reached 85% and 41% respectively, with a determined DIAAS value of 73% for the larvae protein for the first time.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Psychology, Biological
Giulia Chiacchierini, Fabien Naneix, John Apergis-Schoute, James E. McCutcheon
Summary: Protein restriction increases motivation for protein-rich food, but does not affect motivation for nutritionally-balanced food. The increased motivation for protein-rich food disappears once rats are not in need of protein.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Nutrition & Dietetics
Ban-Hock Khor, Dina A. Tallman, Tilakavati Karupaiah, Pramod Khosla, Maria Chan, Joel D. Kopple
Summary: This study evaluated the nutrient composition of plant-based low protein diets and moderately high protein diets for chronic kidney disease patients in the Asia Pacific region. The study found that plant-based diets were deficient in essential amino acids at lower protein prescriptions, but met the Recommended Dietary Allowances at higher protein intakes. Plant-based and vegetarian diets contained higher potassium, phosphorus, and calcium content but lower long-chain n-3 polyunsaturated fatty acids and vitamin B-12 compared to conventional diets. Planning of all low protein diets, especially plant-based and vegetarian diets, should ensure the adequacy of all nutrients, particularly essential amino acids, and consider supplementing with multivitamins and trace elements.
Article
Biochemistry & Molecular Biology
Meaghan C. S. Courvan, Rachel O. Niederer, Isaac W. Vock, Lea Kiefer, Wendy Gilbert, Matthew D. Simon
Summary: Quantitative comparisons of RNA levels using TILAC can distinguish biological variation from variable sample preparation, making it a valuable tool for improving biological insights. TILAC uses metabolic labels to differentially label RNAs and allows for pooling of experimental and control samples before downstream manipulations. The method has been successfully applied to uncover differences in mRNA association with actively translating ribosomes and identify translationally upregulated transcripts.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Nutrition & Dietetics
Marianella Herrera-Cuenca, Martha Cecilia Yepez Garcia, Lilia Yadira Cortes Sanabria, Pablo Hernandez, Yaritza Sifontes, Guillermo Ramirez, Maura Vasquez, Georgina Gomez, Maria Reyna Liria-Dominguez, Attilio Rigotti, Mauro Fisberg, Irina Kovaslkys, Maritza Landaeta-Jimenez
Summary: This study investigated protein intake sources in eight Latin American countries and found associations between protein consumption and demographic factors such as age, gender, and socioeconomic status.
Article
Agriculture, Dairy & Animal Science
James R. Templeman, Anna K. Shoveller
Summary: This study predicts the protein quality (PQ) of ingredients used in commercial dog diet formulation based on indispensable amino acid (IAA) profiles. The choice of IAA reference patterns, whether based on physiological requirements or practical recommendations, significantly affects the predicted PQ of the ingredients. These findings highlight the need for harmonization of PQ equations used in the pet food industry with those used in the human food industry.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Chemistry, Analytical
Weixian Deng, Jihui Sha, Fanglei Xue, Yasaman Jami-Alahmadi, Kathrin Plath, James Wohlschlegel
Summary: In this study, we characterized the molecular factors underlying peptide separation in high-field asymmetric waveform ion mobility spectrometry (FAIMS) and used machine learning to predict optimized compensation voltage values for peptides. These findings improve parallel reaction monitoring workflows and highlight the utility of FAIMS in targeted proteomic applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yuki Murayama, Naoya Yahagi, Yoshinori Takeuchi, Yuichi Aita, Zahra Mehrazad Saber, Nobuhiro Wada, EnXu Li, Xianying Piao, Yoshikazu Sawada, Akito Shikama, Yukari Masuda, Makiko Nishi-Tatsumi, Midori Kubota, Yoshihiko Izumida, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Yoko Sugano, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Hiroaki Suzuki, Hiroaki Yagyu, Yasushi Kawakami, Hitoshi Shimano
Editorial Material
Endocrinology & Metabolism
Takafumi Miyamoto, Takashi Matsuzaka, Hitoshi Shimano
JOURNAL OF DIABETES INVESTIGATION
(2019)
Article
Gastroenterology & Hepatology
Takashi Matsuzaka, Motoko Kuba, Saori Koyasu, Yuta Yamamoto, Kaori Motomura, Sundaram Arulmozhiraja, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Yuka Okajima, Song-iee Han, Yuichi Aita, Yuhei Mizunoe, Yoshinori Osaki, Hitoshi Iwasaki, Shigeru Yatoh, Himaki Suzuki, Hirohito Sone, Yoshinori Takeuchi, Naoya Yahagi, Takafumi Miyamoto, Motohiro Sekiya, Yoshimi Nakagawa, Masatsugu Ema, Satoru Takahashi, Hiroaki Tokiwa, Hitoshi Shimano
Article
Biochemistry & Molecular Biology
Yang Ma, Motohiro Sekiya, Kenta Kainoh, Takaaki Matsuda, Hitoshi Iwasaki, Yoshinori Osaki, Yoko Sugano, Hiroaki Suzuki, Yoshinori Takeuchi, Takafumi Miyamoto, Naoya Yahagi, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Kenta Kainoh, Ryo Takano, Motohiro Sekiya, Kenji Saito, Takehito Sugasawa, Yang Ma, Yuki Murayama, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Yoshinori Takeuchi, Naoya Yahagi, Hiroaki Suzuki, Takafumi Miyamoto, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano
Summary: Molecular oxygen is essential for aerobic organisms, but its utilization is connected with the generation of oxidative insults. Cells evolved antioxidative defense systems to cope with these detrimental aspects, and insufficient management of the oxidative insults underlies the pathogenesis of various diseases. At the transcriptional level, C-terminal binding protein 2 (CtBP2) is an obligate partner of nuclear factor-erythroid 2-like 1 and 2 (NRF1 and NRF2), forming transcriptional complexes that promote the expression of antioxidant genes in response to oxidative insults.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yoshimi Nakagawa, Kae Kumagai, Song-iee Han, Yuhei Mizunoe, Masaya Araki, Seiya Mizuno, Hiroshi Ohno, Kazuya Matsuo, Yasunari Yamada, Jun-dal Kim, Takafumi Miyamoto, Motohiro Sekiya, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Satoru Takahashi, Hirohito Sone, Hitoshi Shimano
Summary: CREBH overexpression leads to growth delay in postnatal stage due to GH resistance and reduced IGF1 levels, despite the increase in FGF21. Inhibition of FGF21 in CREBH L-Tg mice does not correct GH resistance, indicating that CREBH may negatively regulate growth through other pathways.
Article
Biochemistry & Molecular Biology
Reiko Akagi, Takanori Kubo, Yuta Hatori, Takafumi Miyamoto, Sachiye Inouye
Summary: The induction of HO-1 by heat shock is mainly mediated by HSF1 binding to the proximal HSE, while NRF2 binding to MARE is predominantly suppressed by increased BACH1 binding during HS loading.
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Oncology
Ken Tanaka, Shuya Kandori, Shotaro Sakka, Satoshi Nitta, Kozaburo Tanuma, Masanobu Shiga, Yoshiyuki Nagumo, Hiromitsu Negoro, Takahiro Kojima, Bryan J. Mathis, Toru Shimazui, Makoto Watanabe, Taka-Aki Sato, Takafumi Miyamoto, Takashi Matsuzaka, Hitoshi Shimano, Hiroyuki Nishiyama
Summary: This study found that ELOVL2 was highly expressed in ccRCC, pRCC, and chRCC, and its high expression was significantly associated with a poor prognosis. Knockdown of ELOVL2 suppressed the elongation of fatty acids, increased lipid droplet production, and inhibited tumor growth. These findings provide new insights into the tumor proliferation mechanisms involving lipid metabolism and suggest ELOVL2 as a potential novel target for RCC therapy.
Article
Multidisciplinary Sciences
Motohiro Sekiya, Kenta Kainoh, Takehito Sugasawa, Ryunosuke Yoshino, Takatsugu Hirokawa, Hiroaki Tokiwa, Shogo Nakano, Satoru Nagatoishi, Kouhei Tsumoto, Yoshinori Takeuchi, Takafumi Miyamoto, Takashi Matsuzaka, Hitoshi Shimano
Summary: This study highlights the importance of sensing nutrient status in coordinating liver glucose and lipid metabolism. The transcriptional corepressor CtBP2 plays a crucial role in this process, regulating hepatic gluconeogenesis and lipogenesis in response to metabolic perturbations. Understanding the structure-function relationships of CtBP2 could potentially lead to the development of therapeutic strategies for metabolic disorders.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yoshinori Takeuchi, Naoya Yahagi, Yuichi Aita, Zahra Mehrazad-Saber, Man Hei Ho, Yiren Huyan, Yuki Murayama, Akito Shikama, Yukari Masuda, Yoshihiko Izumida, Takafumi Miyamoto, Takashi Matsuzaka, Yasushi Kawakami, Hitoshi Shimano
Summary: KLF15 is a critical transcription factor that regulates gluconeogenesis from amino acids and lipogenesis from glucose. Through the regulation of FoxO1/3, Klf15 gene expression in the liver is controlled, leading to changes in amino acid breakdown and suppression of fatty acid synthesis. This pathway contributes to the macronutrient flow regulation in the liver under insulin control.
Article
Biochemistry & Molecular Biology
Yuka Okajima, Takashi Matsuzaka, Shun Miyazaki, Kaori Motomura, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Nurani Istiqamah, Song-iee Han, Yuhei Mizunoe, Yoshinori Osaki, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Hirohito Sone, Takafumi Miyamoto, Yuichi Aita, Yoshinori Takeuchi, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Tsutomu Tomita, Hitoshi Shimano
Summary: The research found various alterations in pancreatic islet vasculature in obese insulin-resistant mice and type 2 diabetic mice, including capillary dilation, increased blood flow, and decreased endothelial nitric oxide synthase activity. Amelioration of these abnormalities can be achieved through Elovl6 deficiency.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemical Research Methods
Takafumi Miyamoto, Song-Iee Han, Hitoshi Shimano
Summary: The disruption of mitochondrial morphology in various diseases remains poorly understood. A chemically inducible dimerization system-based synthetic protein device was developed for manipulating mitochondrial morphology in living mammalian cells, with potential biological significance. An AI-assisted imaging processing approach was also described in the study.
Article
Biochemical Research Methods
Takafumi Miyamoto, Hideki Uosaki, Yuhei Mizunoe, Song-Iee Han, Satoi Goto, Daisuke Yamanaka, Masato Masuda, Yosuke Yoneyama, Hideki Nakamura, Naoko Hattori, Yoshinori Takeuchi, Hiroshi Ohno, Motohiro Sekiya, Takashi Matsuzaka, Fumihiko Hakuno, Shin-Ichiro Takahashi, Naoya Yahagi, Koichi Ito, Hitoshi Shimano
Summary: A synthetic biomolecular device, iCMM, was developed to manipulate mitochondrial morphology on a minute timescale, leading to changes in cellular behavior. This approach serves as a platform for developing more sophisticated devices to regulate biological systems, and could help uncover the biological significance of mitochondrial morphology in various cellular processes.
CELL REPORTS METHODS
(2021)
Article
Multidisciplinary Sciences
Rahul Sharma, Takashi Matsuzaka, Mahesh K. Kaushik, Takehito Sugasawa, Hiroshi Ohno, Yunong Wang, Kaori Motomura, Takuya Shimura, Yuka Okajima, Yuhei Mizunoe, Yang Ma, Zahara M. Saber, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Yuichi Aita, Song-iee Han, Yoshinori Takeuchi, Naoya Yahagi, Takafumi Miyamoto, Motohiro Sekiya, Yoshimi Nakagawa, Hitoshi Shimano
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)