Oridonin inhibits SASP by blocking p38 and NF-κB pathways in senescent cells

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

(2021) Ines Sturmlechner et al.   SCIENCE

Cellular Senescence: Aging, Cancer, and Injury

(2019) Arianna Calcinotto et al.   PHYSIOLOGICAL REVIEWS

Oridonin inhibits vascular inflammation by blocking NF-κB and MAPK activation

(2018) Weichen Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways

(2018) Jushuang Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB pathways

(2017) Suttinee Phuagkhaopong et al.   NEUROTOXICOLOGY

Oridonin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-induced RAW264.7 cells and acute lung injury

(2017) Gan Zhao et al.   Oncotarget

Oridonin upregulates PTEN through activating p38 MAPK and inhibits proliferation in human colon cancer cells

(2016) QIU-XIANG WU et al.   ONCOLOGY REPORTS

Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide

(2016) X. C. Zheng et al.   POULTRY SCIENCE

Oridonin protects HaCaT keratinocytes against hydrogen peroxide-induced oxidative stress by altering microRNA expression

(2013) SEUNGHEE BAE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK

(2013) HE-QI BU et al.   ONCOLOGY REPORTS

Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells

(2012) FENG-HOU GAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway

(2012) HE-QI BU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium

(2011) Jessica Rennolds et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

(2011) Chun-yang Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

(2010) Feng-Hou Gao et al.   BMC CANCER

Oridonin induces G2/M arrest and apoptosis via activating ERK–p53 apoptotic pathway and inhibiting PTK–Ras–Raf–JNK survival pathway in murine fibrosarcoma L929 cells

(2009) Yan Cheng et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS