Review
Engineering, Biomedical
Chaojie Yu, Fanglian Yao, Junjie Li
Summary: Recently, injectable conducting polymer-based hydrogels have gained attention in tissue engineering due to their controlled conductivity and minimally invasive procedures. Functional CPs play a crucial role in designing these hydrogels and have potential applications in neurological treatment, myocardial repair, and skeletal muscle regeneration.
ACTA BIOMATERIALIA
(2022)
Review
Biotechnology & Applied Microbiology
Parisa Ghandforoushan, Nasim Golafshan, Firoz Babu Kadumudi, Miguel Castilho, Alireza Dolatshahi-Pirouz, Gorka Orive
Summary: The development of hydrogel materials with adhesive and injectable properties is crucial for healthcare applications, as they can be used to treat dysfunctional tissues and have a positive impact on wound healing and dressing processes.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2022)
Article
Chemistry, Physical
Bin Kong, Rui Liu, Yi Cheng, Xiaodong Cai, Junying Liu, Dagan Zhang, Hui Tan, Yuanjin Zhao
Summary: This paper presents a biocompatible and multifunctional adhesive hydrogel based on oxidized guar gum and carboxymethyl chitosan for promoting wound healing. The hydrogel has self-healing ability and shear thinning behavior, allowing it to be easily injected. Its physiochemical properties can be controlled by regulating the concentrations of the hydrogel components. Additionally, the hydrogel exhibits strong adhesion to tissues at physiological temperature.
Article
Chemistry, Physical
Bin Kong, Rui Liu, Yi Cheng, Xiaodong Cai, Junying Liu, Dagan Zhang, Hui Tan, Yuanjin Zhao
Summary: Developing a biocompatible and multifunctional adhesive hydrogel for wound healing is a highly anticipated clinical application. In this paper, a novel natural biopolymer-derived hydrogel based on aldehyde-modified oxidized guar gum (OGG) and carboxymethyl chitosan (CMCS) is presented. The hydrogel has excellent self-healing ability and shear thinning behavior, and can be injected conveniently through a needle. The physiochemical properties of the hydrogel can be controlled by regulating the concentrations of OGG. In addition, the hydrogel can adhere tightly to tissues and promote wound repair by encapsulating vascular endothelial growth factor (VEGF).
Review
Engineering, Biomedical
Fatemeh Poustchi, Hamed Amani, Zainab Ahmadian, Seyyed Vahid Niknezhad, Soraya Mehrabi, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: Combination therapy offers advantages such as simultaneous alteration of biological pathways, reduced drug resistance, and lower treatment costs. Injectable hydrogels serve as an excellent carrier for delivering therapeutic payloads and improving therapeutic responses by forming depots in the body.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Mari C. Manas-Torres, Cristina Gila-Vilchez, Francisco J. Vazquez-Perez, Pavel Kuzhir, David Momier, Jean-Claude Scimeca, Arnaud Borderie, Marianne Goracci, Fanny Burel-Vandenbos, Cristina Blanco-Elices, Ismael A. Rodriguez, Miguel Alaminos, Luis Alvarez de Cienfuegos, Modesto T. Lopez-Lopez
Summary: The incorporation of magnetic nanoparticles in hydrogel matrices has expanded the materials' application in biomedical research by allowing remote modulation of physical properties, inducing anisotropy, and improving mechanical stability. The resulting magnetic short-peptide hydrogels exhibit enhanced mechanical properties, faster self-healing, good biocompatibility, and potential for minimally invasive biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Polymer Science
Jian Yang, Haojie Yu, Li Wang, Jian Liu, Xiaowei Liu, Yichuan Hong, Yudi Huang, Shuning Ren
Summary: Adhesive hydrogels as emerging biomedical materials have attracted much attention for their potential applications in tissue engineering. They possess excellent adhesion, biocompatibility, degradability, and antibacterial properties, making them suitable for hemostatic agents, sealants, and other applications.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Biotechnology & Applied Microbiology
Senbo Zhu, Yong Li, Zeju He, Lichen Ji, Wei Zhang, Yu Tong, Junchao Luo, Dongsheng Yu, Qiong Zhang, Qing Bi
Summary: This paper reviews the research progress on advanced injectable hydrogels for repairing cartilage defects. It thoroughly discusses the cross-linking method and structure of injectable hydrogels, and reviews the commonly used polymers, cells, and stimulators in their preparation. Finally, it summarizes the research progress of the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Mithun Rajendra Dethe, A. Prabakaran, Hafiz Ahmed, Mukta Agrawal, Upal Roy, Amit Alexander
Summary: Stimuli-responsive hydrogels have been extensively studied in biomedical applications due to their biodegradability and biocompatibility. The emergence of in situ stimuli-responsive hydrogels is the result of advancements in synthetic chemistry and materials science. The copolymer PCL-PEG, recognized by the FDA, can form thermosensitive injectable hydrogels that exhibit rapid and reversible gelation behavior.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Applied
Linyu Long, Cheng Hu, Wenqi Liu, Can Wu, Lu Lu, Yang Li, Yunbing Wang
Summary: An injectable multifunctional hydrogel with rapid gelation, self-healing, high water absorbency, tissue adhesiveness and excellent antioxidant activity was fabricated. After loading Ag nanoparticles and recombinant humanized collagen type III, the hydrogel exhibited pH-/H2O2-responsive drug release, cell proliferation promotion, and antibacterial activity. In vivo experiments demonstrated that the hydrogel significantly accelerated wound repair.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Multidisciplinary
Sarah M. Hull, Lucia G. Brunel, Sarah C. Heilshorn
Summary: Using gel-phase materials as bioinks offers advantages in providing cell protection and biological signals. Challenges remain in terms of cell compatibility and biological functionality of bioink materials.
ADVANCED MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Jiahui He, Zixi Zhang, Yutong Yang, Fenggang Ren, Jipeng Li, Shaojun Zhu, Feng Ma, Rongqian Wu, Yi Lv, Gang He, Baolin Guo, Dake Chu
Summary: A series of injectable pH-responsive self-healing adhesive hydrogels have been developed for treating gastric bleeding and wound healing after endoscopic treatment. These hydrogels show great potential as endoscopic sprayable bioadhesive materials, with good hemostatic properties and enhanced wound healing effects in animal models.
NANO-MICRO LETTERS
(2021)
Review
Engineering, Biomedical
Mohammad Hadi Norahan, Sara Cristina Pedroza-Gonz, Monica Gabriela Sanchez-Salazar, Mario Moises Alvarez, Grissel Trujillo de Santiago
Summary: Chronic wounds have become a major problem in healthcare systems, leading to death worldwide. Engineering wound dressings with hydrogels can significantly improve healing time, reduce infections, and lower costs. Hydrogels provide a protective barrier, mimic the extracellular matrix, and create a moist environment. Different fabrication methods and properties of hydrogels have been extensively studied for wound healing applications, including the use of additives to enhance tissue regeneration. Hydrogel engineering offers smart solutions for effective wound healing, with capabilities such as inhibiting bacterial growth, promoting re-epithelialization, and improving tissue functionality.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jinyoung Hwang, Phuong Le Thi, Simin Lee, Eun-Hye Park, Eunmi Lee, Eunmin Kim, Kiyuk Chang, Ki Dong Park
Summary: Although numerous poly(ethylene glycol) (PEG)-based bioadhesives have been developed and commercialized, their biocompatibility and bioactivity performances are generally lacking. To address these issues, chemically crosslinked gelatin-PEG adhesive hydrogels (GP) were designed through the enzymatic crosslinking reaction of horseradish peroxidase (HRP). The GP hydrogels exhibited adjustable mechanical and adhesive properties and effectively improved tissue adhesiveness and bioactivity. They also showed promising potential for hemostatic and wound healing treatments.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Review
Dermatology
Hongyu Wang, Jiaming Wan, Zhiqiang Zhang, Ruixing Hou
Summary: Advancements in GelMA hydrogels are revolutionizing regenerative medicine and tissue engineering, with its potential applications in wound healing and skin regeneration. Challenges remain in scaling up 3D bioprinting techniques and developing advanced bioinks.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)