Critical appraisal of alternative irritation models: three decades of testing ophthalmic pharmaceuticals

First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Novel in situ gelling ocular films for the opioid growth factor-receptor antagonist-naltrexone hydrochloride: Fabrication, mechanical properties, mucoadhesion, tolerability and stability studies

(2014) Hamdy Abdelkader et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Hydrogen-Bonded Complexes and Blends of Poly(acrylic acid) and Methylcellulose: Nanoparticles and Mucoadhesive Films for Ocular Delivery of Riboflavin

(2013) Olga V. Khutoryanskaya et al.   MACROMOLECULAR BIOSCIENCE

Vitrigel-Eye Irritancy Test Method Using HCE-T Cells

(2013) Hiroyuki Yamaguchi et al.   TOXICOLOGICAL SCIENCES

Conjunctival and corneal tolerability assessment of ocular naltrexone niosomes and their ingredients on the hen's egg chorioallantoic membrane and excised bovine cornea models

(2012) Hamdy Abdelkader et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 2: Precorneal retention and in vivo pharmacodynamic study

(2011) Ilva D. Rupenthal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The slug mucosal irritation (SMI) assay: Development of a screening tool for the evaluation of ocular discomfort caused by shampoos

(2011) Joke Lenoir et al.   TOXICOLOGY IN VITRO

HET-CAM test for determining the possible eye irritancy of pesticides

(2010) Péter Budai et al.   ACTA VETERINARIA HUNGARICA

Validating and troubleshooting ocular in vitro toxicology tests

(2010) Frank A. Barile   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Drug-Induced Ocular Disorders

(2009) Junping Li et al.   DRUG SAFETY

Inter-laboratory study of short time exposure (STE) test for predicting eye irritation potential of chemicals and correspondence to globally harmonized system (GHS) classification

(2009) Yutaka Takahashi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Eye irritation

(2009) Pauline McNamee et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom–Up and Top–Down approaches

(2009) Laurie Scott et al.   TOXICOLOGY IN VITRO

Polyoxyethylated nonionic surfactants and their applications in topical ocular drug delivery

(2008) Jim Jiao   ADVANCED DRUG DELIVERY REVIEWS

Cell culture models of the human cornea - a comparative evaluation of their usefulness to determine ocular drug absorption in-vitro

(2008) Stephan Reichl   JOURNAL OF PHARMACY AND PHARMACOLOGY

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

(2008) Guillermo Repetto et al.   Nature Protocols

Safety Evaluation of Ocular Drug Delivery Formulations: Techniques and Practical Considerations

(2008) Brian G. Short   TOXICOLOGIC PATHOLOGY

Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals

(2008) E. Adriaens et al.   TOXICOLOGY IN VITRO