Article
Oncology
Rais Obongo Anga, Muriel Abbaci, Joanne Guerlain, Ingrid Breuskin, Odile Casiraghi, Alix Marhic, Nadia Benmoussa-Rebibo, Heloise de Kermadec, Antoine Moya-Plana, Stephane Temam, Philippe Gorphe, Dana M. Hartl
Summary: Autofluorescence is a new technique that can help surgeons identify parathyroid glands during surgery, reducing the risk of hypoparathyroidism in patients undergoing total laryngectomy. This study found that autofluorescence successfully identified the parathyroid glands in the majority of patients, and reimplanting the glands after cancer resection was safe and did not result in tumor recurrence.
Article
Surgery
Fiona Riordan, Matthew S. Murphy, Linda Feeley, Patrick Sheahan
Summary: Identifying more parathyroid glands during total thyroidectomy (TT) is associated with increased rates of biochemical and symptomatic hypocalcemia, but does not impact permanent hypoparathyroidism or incidental parathyroidectomy.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Supeng Yin, Bin Pan, Zeyu Yang, Mi Tang, Hongbiao Mo, Yao Li, Ziying Yi, Tingjie Yin, Cong Shao, Cunye Yan, Linlong Mo, Yuquan Yuan, Yiceng Sun, Fan Zhang
Summary: The combined use of autofluorescence (AF) and indocyanine green fluorescence (ICGF) during total thyroidectomy reduces the risk of postoperative hypoparathyroidism, enhances the ability to identify and preserve parathyroid glands (PGs), and improves the accuracy of evaluating PG perfusion during surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Otorhinolaryngology
Diego Barbieri, Michela Nicole Melegatti, Alessandro Vinciguerra, Pietro Indelicato, Leone Giordano, Stefano Bondi, Matteo Biafora, Matteo Trimarchi, Mario Bussi
Summary: The use of near-infrared autofluorescence in pharyngo-laryngectomy surgery can aid in identifying and preserving parathyroid glands, leading to a lower incidence of postoperative hypocalcemia.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Surgery
Zhichao Xing, Yuxuan Qiu, Baoying Xia, Munire Abuduwaili, Yuan Fei, Jingqiang Zhu, Anping Su
Summary: Parathyroid protection remains controversial in patients with fewer than 4 parathyroid glands during thyroidectomy. This study found that patients with only 3 identified parathyroid glands had lower serum PTH and calcium levels postoperatively, with a higher incidence of hypocalcemia. Patients who underwent parathyroid autotransplantation had significantly lower PTH levels compared to those with all parathyroid glands preserved in situ.
Article
Surgery
Jennifer Triguero Cabrera, Elena Fernandez Segovia, Selene Gonzalez Martinez, Nuria Victoria Munoz Perez, Juan Ignacio Arcelus Martinez, Manuela Exposito Ruiz, Jesus Maria Villar del Moral
Summary: The study identified a higher number of parathyroid glands and a higher gradient of parathormone decline as independent risk factors for post-thyroidectomy hypocalcaemia. A predictive model named NuGra was developed based on these factors, showing high predictive power with AUROC values of 0.902 for the study group and 0.956 for the validation group.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Otorhinolaryngology
Eva Lykke, Anders Christensen, Karina Juhl, Ulla Feldt-Rasmussen, Mette Friberg Hitz, Sannia Mia Svenningsen Sjostedt, Christoffer Holst Hahn, Ditte Maria Kraik Svensson, Karoline Kanstrup Springborg, Mads Georg Stage, Gitte Bjorn Hvilsom, Linda Maria Hilsted, Morten Dahl, Giedrius Lelkaitis, Andreas Kjaer, Preben Homoe, Christian von Buchwald
Summary: The purpose of this study was to investigate whether near-infrared autofluorescence image guidance can reduce the incidence of hypoparathyroidism in total thyroidectomy. The results showed that near-infrared autofluorescence imaging can improve the detection rate of parathyroid glands and reduce the rate of hypoparathyroidism, but the difference was not statistically significant. Further studies are needed to confirm the use of near-infrared autofluorescence imaging as an auxiliary tool for parathyroid gland identification.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Endocrinology & Metabolism
Stefanie Seo, Khalid Mohamed Ali, Samantha A. Wolfe, Nimesh V. Nagururu, Andy S. Ding, Dipan Desai, R. Alex Harbison, Yoseph Kim, Bo Ning, Richard Jaepyeong Cha, Jonathon O. Russell
Summary: This study explored the use of the hANDY-i endoscopic attachment for detecting parathyroid glands during transoral thyroidectomy. The device successfully visualized the parathyroid glands using a split screen view of RGB and NIRAF. This technique may improve the localization and preservation of parathyroid glands, but further studies are needed to assess its impact on postoperative hypocalcemia and hypoparathyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Young Seok Han, Yikeun Kim, Hyoung Shin Lee, Yeongjoon Kim, Yeh-Chan Ahn, Kang Dae Lee
Summary: Near-infrared autofluorescence (NIRAF) imaging can be used to detect parathyroid glands (PGs). In this study, the maximum detectable depth of unexposed PGs during thyroidectomy was found to be 3.05 mm, with an average depth of 1.23 mm. Additionally, a novice was able to successfully localize 80.4% of the unexposed PGs. These findings provide valuable reference data for the localization of unexposed PGs in thyroid surgery.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Surgery
Volodymyr V. Grubnik, Roman S. Parfentiev, Yurii V. Grubnik, Viktor V. Grubnyk
Summary: Near-infrared fluorescent imaging combined with intraoperative parathyroid gland indocyanine green angiography can help identify and preserve parathyroid glands during total thyroidectomy, thus avoiding postoperative hypocalcemia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Dengwei Lu, Enjie Tang, Supeng Yin, Junping Zhu, Hongbiao Mo, Ziying Yi, Fan Chai, Yizeng Sun, Yao Li, Tingjie Yin, Zeyu Yang, Fan Zhang
Summary: This retrospective cohort study aimed to investigate influential factors in the occurrence and restoration of postoperative hypoparathyroidism (POH) in thyroid cancer patients who underwent total thyroidectomy with intraoperative parathyroid autotransplantation (TTIPA). The study found that high postoperative fasting blood glucose levels, a large number of transplanted parathyroid glands, open surgery, and Hashimoto's thyroiditis are risk factors for postoperative POH. Female patients and patients without same-side central lymph node dissection (CLND) on the transplant side are more prone to increased PTH levels. Patients without CLND and those who underwent endoscopic surgery on the transplant side have a faster PTH restoration.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Takeshi Takahashi, Keisuke Yamazaki, Hisayuki Ota, Ryusuke Shodo, Yushi Ueki, Arata Horii
Summary: The study evaluated the effectiveness of near-infrared fluorescence imaging in identifying parathyroid glands, showing comparable accuracy between NIFI and a surgeon's visual inspection. NIFI demonstrated higher sensitivity in detecting PGs from thyroidectomy specimens compared to the surgeon's visual inspection.
Article
Endocrinology & Metabolism
Xiaozhou Cheng, Yaping Li, Lijun Chen
Summary: The purpose of this study was to evaluate the safety and efficacy of autologous parathyroid transplantation in laparoscopic total thyroidectomy combined with central lymph node dissection. The results showed that preserving the parathyroid glands during the surgery helped prevent hypoparathyroidism after the operation, and it was an effective strategy to prevent permanent hypoparathyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Otorhinolaryngology
Do Hyun Kim, So-Hyun Kim, Jaehoon Jung, Sung Won Kim, Se Hwan Hwang
Summary: The study evaluated the diagnostic accuracies of ICG fluorescence for identifying parathyroid glands during surgery and predicting postoperative function. ICG was found to effectively identify parathyroid glands and predict function, which is valuable for patients undergoing thyroid surgery.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Medicine, General & Internal
Antonio Sitges-Serra
Summary: Postoperative parathyroid failure after total thyroidectomy is a common complication that can be influenced by various factors, making the diagnostic and treatment process complex.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
A. Bravo-Salva, A. M. Gonzalez-Castillo, F. F. Vela-Polanco, E. Membrilla-Fernandez, J. Vila-Domenech, M. Pera-Roman, J. J. Sancho-Insenser, J. A. Pereira-Rodriguez
WORLD JOURNAL OF SURGERY
(2020)
Editorial Material
Surgery
Nuria Martinez Sanz, Leyre Lorente Poch, Estuardo Danilo Torselli Valladares, Juan Jose Sancho Insenser, Antonio Sitges Serra
Article
Endocrinology & Metabolism
Sabina Ruiz, Antonio Jesus Amor, Adriana Pane, Alicia Molina-Andujar, Enrique Montagud-Marrahi, Pedro Ventura-Aguiar, Joana Ferrer-Fabrega, Enric Esmatjes
DIABETES RESEARCH AND CLINICAL PRACTICE
(2020)
Article
Endocrinology & Metabolism
C. Vinals, I. Conget, A. Pane, L. Boswell, V. Perea, A. J. Blanco, S. Ruiz, M. Gimenez, I. Vinagre, E. Esmatjes, E. Ortega, A. J. Amor
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2020)
Article
Endocrinology & Metabolism
Adriana Pane, Ignacio Conget, Laura Boswell, Sabina Ruiz, Clara Vinals, Veronica Perea, Marga Gimenez, Montserrat Cofan, Jesus Blanco, Irene Vinagre, Enric Esmatjes, Emilio Ortega, Antonio J. Amor
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2020)
Review
Surgery
Kerstin Lorenz, Marco Raffaeli, Marcin Barczynski, Leyre Lorente-Poch, Joan Sancho
LANGENBECKS ARCHIVES OF SURGERY
(2020)
Correction
Surgery
A. Bravo-Salva, A. M. Gonzalez-Castillo, F. F. Vela-Polanco, E. Membrilla-Fernandez, J. Vila-Domenech, M. Pera-Roman, J. J. Sancho-Insenser, J. A. Pereira-Rodriguez
WORLD JOURNAL OF SURGERY
(2020)
Article
Immunology
Enrique Montagud-Marrahi, Alicia Molina-Andujar, Adriana Pane, Sabina Ruiz, Antonio J. Amor, Enric Esmatjes, Joana Ferrer, Elisenda Banon-Maneus, Evelyn Hermida, Mireia Musquera, Constantino Fondevila, Fritz Diekmann, Pedro Ventura-Aguiar
Summary: This study investigated whether simultaneous pancreas-kidney transplantation (SPKT) can reduce the risk of cardiovascular disease in patients with type 1 diabetes. The results showed that SPKT significantly decreased the predicted cardiovascular risk by the STENO T1. Additionally, the success of pancreas transplantation was found to be unrelated to the incidence of cardiovascular events.
Article
Cardiac & Cardiovascular Systems
Tonet Seres-Noriega, Marga Gimenez, Veronica Perea, Jesus Blanco, Irene Vinagre, Adriana Pane, Sabina Ruiz, Monserrat Cofan, Alex Mesa, Enric Esmatjes, Ignacio Conget, Emilio Ortega, Antonio J. Amor
Summary: In patients with type 1 diabetes, H-1-NMR glycoproteins were independently associated with the presence and extent of carotid atherosclerosis in those not receiving lipid-lowering treatment, unlike other classical inflammatory markers. Further research is needed to explore their potential as cardiovascular disease biomarkers.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Antonio J. Amor, Aida Casas, Adriana Pane, Sabina Ruiz, Enrique Montagud-Marrahi, Alicia Molina-Andujar, Montserrat Ruiz, Rosa Mayordomo, Mireia Musquera, Joana Ferrer-Fabrega, Constantino Fondevila, Fritz Diekmann, Pedro Ventura-Aguiar, Enric Esmatjes
Summary: The study evaluated weight trajectories after pancreas transplantation in T1D individuals and found a significant weight loss at 6 months post-transplant, followed by a gradual increase. Participants from 2010-2015 showed higher weight gain, surpassing the control group. Weight gain was associated with glucose-related biochemical markers, but the risk of graft failure/dysfunction was not significant after adjusting for age, sex, and other variables.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Endocrinology & Metabolism
Sabina Ruiz, Federico Vazquez, Silvia Pellitero, Manel Puig-Domingo
Summary: This paper reviews the recent knowledge on obesity-related pituitary dysfunction and its pathogenic mechanisms, and discusses potential therapeutic actions aimed at improving the complex treatment of severe cases of obesity.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Nancy Perrier, Brian H. Lang, Leonardo Costa Bandeira Farias, Leyre Lorente Poch, Mark Sywak, Martin Almquist, Menno R. Vriens, Michael W. Yeh, Omair Shariq, Quan-Yang Duh, Randy Yeh, Thinh Vu, Virginia LiVolsi, Antonio Sitges-Serra
Summary: This review provides an update on the surgical aspects of primary hyperparathyroidism (PHPT), focusing on parathyroidectomy (PTX) as the treatment of choice. The review proposes definitions for different types of PTX procedures and discusses various aspects of surgery, including intraoperative management and postoperative complications. It also covers the use of intraoperative parathyroid hormone (PTH) measurement and the management of low bone mineral density (BMD) after PTX. The review represents the first global consensus on surgery in PHPT and reflects current practices in leading endocrine surgery units worldwide.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Sabina Ruiz, Joan Gil, Betina Biagetti, Eva Venegas, Rosa Camara, Rogelio Garcia-Centeno, Maria-angeles Galvez, Antonio Pico, Silvia Maraver, Inmaculada Gonzalez, Pablo Abellan, Pablo Trincado, Mayte Herrera, Pilar Olvera, Gemma Xifra, Ignacio Bernabeu, Guillermo Serra-Soler, Sharona Azriel, Lourdes Garcia, Davide Carvalho, Mireia Jorda, Elena Valassi, Josep Puig, Manel Puig-Domingo
Summary: The study aimed to evaluate the relationship between T2 MRI signal intensity and pasireotide therapeutic effectiveness. It was found that T2 hyperintensity signal was more frequently observed in pasireotide treated patients. Furthermore, almost 60% of acromegaly patients achieved complete normalization of IGF-I levels after 1 year of pasireotide treatment, regardless of the MRI signal.
CLINICAL ENDOCRINOLOGY
(2023)
Meeting Abstract
Surgery
M. C. de Jong, L. Lorente-Poch, J. Sancho, V. Rozalen Garcia, C. Brain, T. E. Abdel-Aziz, R. J. Hewitt, A. Sitges-Serra, T. R. Kurzawinski
BRITISH JOURNAL OF SURGERY
(2020)
Meeting Abstract
Surgery
J. J. Sancho-Insenser, A. Sitges-Serra
BRITISH JOURNAL OF SURGERY
(2020)