Review
Pharmacology & Pharmacy
Francisca Villanueva-Flores, Andres Zarate-Romero, Alfredo G. Torres, Alejandro Huerta-Saquero
Summary: Nano- and micro-encapsulation are promising approaches to enhance the in vivo performance of ASNase, protecting the enzyme from degradation, increasing its catalytic half-life, and reducing immunogenicity. Various strategies and the use of different nanocarriers are discussed to ultimately provide safer and more effective treatments for patients with ALL.
Review
Engineering, Biomedical
Biao-Qi Chen, Yi Zhao, Yang Zhang, Yu-Jing Pan, Hong-Ying Xia, Ranjith Kumar Kankala, Shi-Bin Wang, Gang Liu, Ai-Zheng Chen
Summary: This article reviews the challenges in nano-immunotherapy related to immune elimination and immunosuppressive microenvironment in cancer treatment. To address these issues, immune-regulating camouflaged nanocomposites have emerged as prevailing strategies. The article discusses the composition, performances, and mechanisms of various immune-regulating nanoplatforms and their applications in cancer immunotherapy and other immunotherapeutic modalities.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Caroline Elias, Maud Nemoz, Helene Rotella, Frederic Georgi, Stephane Vezian, Maxime Hugues, Yvon Cordier
Summary: For the first time, ScAlN growth has been carried out by molecular beam epitaxy using ammonia as the nitrogen precursor. The study shows that smooth surface morphology with a mean roughness below 0.5 nm can be achieved at any growth temperature. X-ray diffraction rocking curves indicate minimum full-width at half-maximum of 620 and 720 arc sec for (0002) and (1013) crystal planes at a temperature of 670°C. Additionally, high-density two-dimensional electron gases of 3-3.5 x 10(13)/cm(2) were observed in the heterostructures grown below 720°C.
Article
Microbiology
Eman F. E. Mohamed, Abd El-Salam E. Hafez, Hanan G. Seadawy, Mohamed F. M. Elrefai, Karima Abdallah, Rasha M. El Bayomi, Abdallah Tageldein Mansour, Mahmoud M. Bendary, Abdullah M. Izmirly, Bandar K. Baothman, Khairiah Mubarak Alwutayd, Abdallah F. A. Mahmoud
Summary: Fish is a good source of protein and essential minerals and vitamins, but several food-borne disease outbreaks have been linked to fish consumption. This study evaluated gamma radiation as a method to preserve fish and reduce microbial contamination. The results showed that gamma irradiation effectively reduced aerobic plate count and pathogenic bacteria in fish samples, while having no significant effect on fish quality. Gamma irradiation is proposed as a cheap and safe method for reducing microbial contamination in fish.
Article
Pharmacology & Pharmacy
Songyi Park, Sunghye Lee, Dongyeop Kim, Hyejeong Kim, Young-Guen Kwon
Summary: CU06-1004, an endothelial dysfunction blocker, co-administered with HDIL-2 prevented HDIL-2-induced vascular leakage and reduced tumor growth in a mouse model.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Meteorology & Atmospheric Sciences
Cheng Liu, Meng Gao, Qihou Hu, Guy P. Brasseur, Gregory R. Carmichael
Summary: Developing an international stereoscopic monitoring strategy is crucial to reduce uncertainties and advance diagnostic understanding and prediction of air pollution. Establishing stereoscopic monitoring networks, sharing monitoring data, optimizing air quality management, and protecting human health are key priorities for researchers and policymakers.
BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
(2021)
Article
Chemistry, Physical
Jianqiang Guo, Shiqi Liu, Maoxia Yang, Shaomin Li, Gen Zhang, Hao Liu
Summary: This study investigates the fading of graphite anode at low temperature from the perspective of Li+ storage mechanism. It is found that the amorphous hard carbon (HC) electrode exhibits higher lithiation capacity than graphite and mesocarbon microbead (MCMB) electrodes at -20 degrees C, primarily due to the surface-induced capacitive storage mechanism. This work highlights the potential of utilizing surface-induced capacitive storage mechanism to improve low temperature electrochemical performance.
Article
Chemistry, Physical
Nguyet-Minh Nguyen Le, Christian Steinbring, Bao Le-Vinh, Aamir Jalil, Barbara Matuszczak, Andreas Bernkop-Schnuerch
Summary: This study aimed to develop a drug delivery system that changes the zeta potential by decorating lipid-based nanocarriers with a polycationic cell penetrating peptide (CPP) and masking these cationic substructures with polyphosphates. The polyphosphate-coated PLL-decorated nanocarriers showed improved cellular uptake and significant conversion of zeta potential.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Wei Luo, Zhe Liu, Ding Zuo, Xiaoshuai Wang, Yanni Tu, Ruiqian Zhang, Huiqun Liu
Summary: This study proposes a new strategy to obtain irregular grain boundary serrations as a way to improve mechanical properties of alloys at high temperatures. The formation mechanism of these serrations through recrystallization annealing is revealed, and their effects on ductility and strength are investigated. The results show that grain boundary serrations can significantly enhance ductility while maintaining strength.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2023)
Review
Polymer Science
Carlos Henrique Bertoni Reis, Daniela Vieira Buchaim, Adriana de Cassia Ortiz, Simone Ortiz Moura Fideles, Jefferson Aparecido Dias, Maria Angelica Miglino, Daniel de Bortoli Teixeira, Eliana de Souza Bastos Mazuqueli Pereira, Marcelo Rodrigues da Cunha, Rogerio Leone Buchaim
Summary: Fibrin, a biopolymer derived from proteins involved in blood clotting, has various applications in the health area. Its combination with photobiomodulation (PBM) can stimulate cell activity, angiogenesis, osteoblast activation, and collagen synthesis.
Article
Environmental Sciences
Shengpeng Wang, Wei Zhang, Aizhi Cao, Zhongchao Pan, Tailiang Liu
Summary: This study demonstrates the beneficial effects of dietary bile acids on hepatic health in tongue sole, including improved growth performance, survival rate, and various physiological and biochemical parameters of the liver.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Jeff K. Kerkovius, Alice R. Wong, Victor W. Mak, Sarah E. Reisman
Summary: The formation of quaternary stereogenic centers in polycyclic systems is achieved via a strategy based on the semi-pinacol reaction. Two fragments of similar size and complexity are joined by alkenyl lithium addition to an epoxy ketone, followed by a semi-pinacol rearrangement. Polycyclic scaffolds with quaternary stereogenic centers are generated in high yields, tolerating various functional groups. This method provides a useful strategy for the synthesis of complex polycyclic natural product-like scaffolds.
Review
Immunology
Wei Zhang, Hao Cheng, Yuanyuan Gui, Qipeng Zhan, Si Li, Wenliang Qiao, Aiping Tong
Summary: This review explores the therapeutic functions of mannose in inflammatory diseases, highlighting its ability to suppress inflammation by inducing regulatory T cells, inhibiting effector T cells, and modulating the gut microbiome for anti-inflammatory effects. The findings suggest that mannose treatment is a safe and promising strategy for suppressing inflammatory diseases, including autoimmune and allergic conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Tamara Savage, Alex Davis, Baruch Fischhoff, M. Granger Morgan
Summary: Forecasts of future technologies are often inaccurate and overconfident, leading to a proposed hybrid approach that combines technical domain experts with experts on broader issues to improve accuracy. A pilot study showed that briefings on factors beyond technology led to wider forecast intervals, potentially aiding decision-makers in understanding the uncertainties of technology forecasts.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Physical
Dong Xie, Yi Chang, Tao Liu, Zhili Li, Jun Luo
Summary: This study reports the discovery of a ductile silver chalcogenide with a cubic structure, which is stabilized at room temperature through alloying effect. By adding a small amount of excessive selenium, the thermoelectric properties of the material have been improved, showing promising potential for practical applications.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Tai Li, Wei Luo, Shangfeng Liu, Jiajia Yang, Renchun Tao, Ye Yuan, Zhaoying Chen, Jinlin Wang, Tao Wang, Xin Rong, Duo Li, Zhen Huang, Weiyun Wang, Junjie Kang, Xinqiang Wang
Summary: In this study, a substrate-dominated strain-modulation strategy was proposed to suppress the compressive strain in AlGaN-based UVB-LEDs, achieving outstanding performance with high LOP and stability.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Physics, Applied
Ding Wang, Ping Wang, Shubham Mondal, Mingtao Hu, Danhao Wang, Yuanpeng Wu, Tao Ma, Zetian Mi
Summary: The thickness scaling behavior of ferroelectric Sc0.3Al0.7N films grown on Mo substrates by molecular beam epitaxy is reported. The switchable ferroelectricity in ScAlN films with thicknesses ranging from 100 to 5 nm is confirmed. The increase in coercive field and diminution of remnant polarization in films below 20 nm are closely related to surface oxidation and strain state in ultrathin ScAlN films.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Zhouzhou Wang, Bowen Sheng, Yiqing Chen, Sharif Md. Sadaf, Jinglin Li, Jiajia Yang, Jun Song, Lin Yao, Ying Yu, Lei Zhu, Xinqiang Wang, Zhen Huang, Baowen Zhou
Summary: This work presents a novel photocatalytic architecture of AuIn NPs/GaN NWs/Si for the production of green syngas from bio-derived glycerol. The system shows remarkable activity and selectivity under mild conditions, without requiring additional energy input.
Article
Chemistry, Multidisciplinary
Ayush Pandey, Jungwook Min, Maddaka Reddeppa, Yakshita Malhotra, Yixin Xiao, Yuanpeng Wu, Kai Sun, Zetian Mi
Summary: By developing nanowire excitonic LEDs, the challenge of reduced efficiency in quantum well LEDs at small dimensions can be overcome. A submicron scale green-emitting LED with an external quantum efficiency of 25.2% and a wall-plug efficiency of 20.7% was achieved, the highest values reported for LEDs of this size to our knowledge. Critical factors for achieving excitonic micro-LEDs were identified, including epitaxy of nanostructures for strain relaxation, utilization of semipolar planes to minimize polarization effects, and formation of nanoscale quantum confinement to enhance electron-hole wave function overlap. This work provides a viable path to break the efficiency bottleneck of nanoscale optoelectronics.
Article
Multidisciplinary Sciences
Peng Zhou, Ishtiaque Ahmed Navid, Yongjin Ma, Yixin Xiao, Ping Wang, Zhengwei Ye, Baowen Zhou, Kai Sun, Zetian Mi
Summary: Production of hydrogen fuel from sunlight and water is a promising pathway for carbon neutrality. A strategy using pure water, concentrated solar light, and an indium gallium nitride photocatalyst has achieved a solar-to-hydrogen efficiency of 9.2%. The strategy promotes forward hydrogen-oxygen evolution and inhibits reverse hydrogen-oxygen recombination by operating at an optimal reaction temperature, which can be achieved by harvesting infrared light in sunlight.
Article
Nanoscience & Nanotechnology
Ping Wang, Ding Wang, Shubham Mondal, Mingtao Hu, Yuanpeng Wu, Tao Ma, Zetian Mi
Summary: Achieving ferroelectricity in III-nitride semiconductors by alloying with rare-earth elements, such as scandium, has opened up possibilities for next-generation electronic, acoustic, photonic, and quantum devices and systems. However, the integration of nitride semiconductors with the complementary metal oxide semiconductor (CMOS) technology has been hindered by the need for sapphire, Si, or SiC substrates. In this study, we demonstrate the growth of single-crystalline ferroelectric nitride semiconductors on CMOS compatible metal-molybdenum, enabling the realization of ferroelectric nitride semiconductors on polycrystalline molybdenum. Robust and wake-up-free ferroelectricity has been measured in the epitaxially grown ScAlN directly on metal, and a ferroelectric GaN/ScAlN heterostructure for synaptic memristor has been proposed and demonstrated, showing potential applications in neuromorphic computing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ding Wang, Ping Wang, Shubham Mondal, Mingtao Hu, Yuanpeng Wu, Tao Ma, Zetian Mi
Summary: Computing in the analog regime using nonlinear ferroelectric resistive memory arrays can potentially alleviate the energy constraints and complexity/footprint challenges imposed by digital von Neumann systems. In this study, ferroelectric and analog resistive switching in an epitaxial nitride heterojunction comprised of ultrathin nitride ferroelectrics, specifically ScAlN, has been demonstrated. The results show high ON/OFF ratios, uniformity, retention, and cycling endurance, along with the capability for multistate operation and image processing.
ADVANCED MATERIALS
(2023)
Article
Physics, Applied
Yuanpeng Wu, Ping Wang, Woncheol Lee, Anthony Aiello, Parag Deotare, Theodore Norris, Pallab Bhattacharya, Mackillo Kira, Emmanouil Kioupakis, Zetian Mi
Summary: Both 2D TMDs and III-V semiconductors are potential platforms for quantum technology, but each with its limitations. 2D TMDs have a large exciton binding energy and customizable quantum properties, but compatibility issues with existing industrial processes. On the other hand, III-nitrides have been widely used in light-emitting devices and power electronics but lack exploitation of excitonic quantum aspects. Recent advancements in 2D III-nitrides have shown promise in achieving room-temperature quantum technologies.
APPLIED PHYSICS LETTERS
(2023)
Article
Physics, Applied
Ding Wang, Ping Wang, Minming He, Jiangnan Liu, Shubham Mondal, Mingtao Hu, Danhao Wang, Yuanpeng Wu, Tao Ma, Zetian Mi
Summary: In this Letter, fully epitaxial ScAlN/AlGaN/GaN based ferroelectric high electron mobility transistors (HEMTs) were demonstrated using molecular beam epitaxy. The fabricated ferroelectric gate HEMTs showed counterclockwise hysteretic transfer curves with a wide threshold voltage tuning range, a large ON/OFF ratio, and reconfigurable output characteristics. The high quality ferroelectric gate stack and effective ferroelectric polarization coupling lead to improved subthreshold performance. These results provide fundamental insight into the ferroelectric polarization coupling and threshold tuning processes in ferroelectric nitride heterostructures and have promising applications in next-generation electronics.
APPLIED PHYSICS LETTERS
(2023)
Article
Multidisciplinary Sciences
Prashant Kumar, Thi Vo, Minjeong Cha, Anastasia Visheratina, Ji-Young Kim, Wenqian Xu, Jonathan Schwartz, Alexander Simon, Daniel Katz, Valentin Paul Nicu, Emanuele Marino, Won Jin Choi, Michael Veksler, Si Chen, Christopher Murray, Robert Hovden, Sharon Glotzer, Nicholas A. Kotov
Summary: Bowtie nanostructured microparticles display a continuum of chirality and can be used to create photonically active metasurfaces with tuneable polarization signatures for light detection and ranging (LIDAR) devices.
Article
Chemistry, Physical
Jiaming Wang, Nan Xie, Fujun Xu, Lisheng Zhang, Jing Lang, Xiangning Kang, Zhixin Qin, Xuelin Yang, Ning Tang, Xinqiang Wang, Weikun Ge, Bo Shen
Summary: We propose a method to achieve high-quality III-nitride heteroepitaxial films by controlling the discretization and coalescence of columns. By using nano-patterned AlN/sapphire templates, discrete AlN columns coalesce with uniform orientations, effectively suppressing the regeneration of threading dislocations. The resulting AlN heteroepitaxial film shows a density of dislocation etch pits close to that of bulk single crystals.
Editorial Material
Materials Science, Multidisciplinary
Grace Xing, Zetian Mi, Srabanti Chowdhury
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Shanshan Sheng, Duo Li, Ping Wang, Tao Wang, Fang Liu, Zhaoying Chen, Renchun Tao, Weikun Ge, Bo Shen, Xinqiang Wang
Summary: The lattice-asymmetry-driven selective area sublimation (SAS) process of GaN is investigated through in situ dynamic evolution of the decomposition pathway under ultra-high vacuum. The SAS is confirmed as a strongly anisotropic decomposition driven by lattice-asymmetry of wurtzite crystal, with sublimation starting preferably along the -c axis due to lower decomposition energy barrier. Site- and size-controlled GaN nanowires have been successfully fabricated using the SAS process, demonstrating controllability on the sidewall of the nanowires. These findings provide insights into the thermodynamic mechanism of lattice-asymmetry-driven sublimation process in III-nitrides and offer an efficient alternative for semiconductor micro/nanostructure tailoring.
PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Liubing Wang, Fujun Xu, Jing Lang, Jiaming Wang, Lisheng Zhang, Xueqi Guo, Chen Ji, Xiangning Kang, Xuelin Yang, Xinqiang Wang, Zhixin Qin, Weikun Ge, Bo Shen
Summary: Thinning the p-AlGaN/p-GaN layer and adopting Ni/Au/Al composite electrodes have been attempted to improve the light extraction efficiency (LEE) of AlGaN-based deep-ultraviolet (DUV) light emitting diodes (LEDs). It is found that the thin p-AlGaN/p-GaN layer reduces light absorption, and the Ni/Au/Al electrodes achieve high reflectivity and Ohmic contact, enhancing light extraction and maintaining fine electrical properties. By using optimized Ni/Au/Al reflective electrodes, the maximum external quantum efficiency of DUV-LEDs is increased by 40% compared to conventional Ni/Au electrodes over the entire current range.
IEEE PHOTONICS JOURNAL
(2023)
Article
Multidisciplinary Sciences
Prashant Kumar, Thi Vo, Minjeong Cha, Anastasia Visheratina, Ji-Young Kim, Wenqian Xu, Jonathan Schwartz, Alexander Simon, Daniel Katz, Valentin Paul Nicu, Emanuele Marino, Won Jin Choi, Michael Veksler, Si Chen, Christopher Murray, Robert Hovden, Sharon Glotzer, Nicholas A. Kotov
Summary: This study demonstrates nanostructured microparticles with continuously tunable chirality, which have a chiral shape similar to traditional handiness and can be controlled by adjusting different parameters. Unlike classical chiral molecules, these particles show a continuum of chirality measures and can be used to produce tunable frequency photonic active metasurfaces.