Review
Chemistry, Multidisciplinary
Sam Benson, Fabio de Moliner, William Tipping, Marc Vendrell
Summary: Recent progress in optical bioimaging has led to the demand for minimal chemical reporters that can preserve the properties and activities of biomolecules. Various approaches have been developed to reduce the size of fluorescent and Raman labels to a few atoms and incorporate them into building blocks to form native-like supramolecular structures. This integration of small optical reporters into biomolecules has enabled the creation of previously inaccessible smart molecular entities, greatly expanding their applications in biological imaging.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Spectroscopy
M. Kopec, M. Blaszczyk, M. Radek, H. Abramczyk
Summary: This study evaluates the Raman biomarkers to distinguish tumor types, demonstrating that specific frequency bands in the spectra can serve as universal biomarkers for assessing the aggressiveness of human brain tumors. The clinical potential of Raman spectroscopy in oncological diagnostics is confirmed by the presented results.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Siddra Maryam, Sanathana Konugolu Venkata Sekar, M. Daniyal Ghauri, Edward Fahy, Marcelo Saito Nogueira, Huihui Lu, Flavien Beffara, Georges Humbert, Richeal Ni Riordain, Patrick Sheahan, Ray Burke, Kiang Wei Kho, Rekha Gautam, Stefan Andersson-Engels
Summary: Early diagnosis of oral cancer is critical for improving patient survival rates. Raman spectroscopy has shown promise as a non-invasive method for identifying early-stage oral cancer biomarkers. However, its widespread use is limited due to weak signals that require costly sensitive detectors. In this research, a customised Raman system is developed to reduce costs for different applications and demonstrate the potential for complete oral cancer screening.
Article
Chemistry, Physical
Shota Takahashi, Atsunori Sakurai, Tatsuto Mochizuki, Toshiki Sugimoto
Summary: In this study, we achieved significant enhancement of the nonlinear optical response in a tip-substrate plasmonic nanocavity. By focusing on the near-field second harmonics of a wavelength-tunable femtosecond laser, we demonstrated that the enhancement of nonlinear optical effects occurs over a broad wavelength range from visible to infrared. We also discovered that the sharpness of the tip apexes and the surface geometry of the tip shafts both affect the broadband nonlinear optical property.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Analytical
Guohua Qi, Xing Du, Xuan Yi, Minmin Wang, Hongyan Zhu, Dan Sun
Summary: In this study, a dual-channel microfluidic droplet platform combining surface-enhanced Raman spectroscopy (SERS) and fluorescence was developed for the highly sensitive determination of low-abundance telomerase activity in single cells. This platform allows for the investigation of cell heterogeneity and dynamic monitoring of intracellular telomerase activity during telomerase inhibitor treatment.
Article
Chemistry, Multidisciplinary
Yue Yuan, Piyush Raj, Jia Zhang, Soumik Siddhanta, Ishan Barman, Jeff W. M. Bulte
Summary: Olsalazine acts as a broad-spectrum anti-cancer agent by inhibiting DNA methylation, and when conjugated with the tumor enzyme furin, it can self-assemble into nanoparticles that can be detected with high specificity using Raman spectroscopy. This sensing mechanism has potential applications in high-resolution image-guided surgery for precise delineation of tumor margins and determining microscopic tumor invasion and multifocal locoregional tumor spread.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Aizong Shen, Lei Zhang, Yanbo Xie, Xueyu Zhu, Jinming Hu, Shiyong Liu
Summary: Synthetic polymers have been widely used in biomedical fields for imaging and therapeutic purposes. Discrete polymers, characterized by precise molecular weight and no molecular weight distribution, have shown promising potential in optical imaging, magnetic resonance imaging, and therapeutic applications. The development of efficient synthetic strategies and further (pre)clinical studies are needed to facilitate the clinical translation of discrete polymers into precision nanomedicines.
Article
Chemistry, Medicinal
Carlos Cruz-Hernandez, Luis Jose Lopez-Mendez, Patricia Guadarrama
Summary: Nanomedicine uses rational design of new materials to improve therapies, and dendronization is a cost-effective approach that enhances essential properties of molecular systems.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Chi Shu, Wei Zheng, Kan Lin, Chwee Ming Lim, Zhiwei Huang
Summary: This study demonstrates the ability of rapid fiberoptic Raman endoscopy to stage and diagnose nasopharyngeal cancer in real-time. By analyzing Raman spectra of tissue sites, a staging model is established with high accuracy. The findings show that fiberoptic Raman endoscopy is a robust tool for clinical staging of nasopharyngeal cancer.
Article
Chemistry, Analytical
Xinyi Hu, Xianbao Sun, Xiaoyang Liu, Hai-Dong Xu, Liang Yang, Songqin Liu, Rui Wang, Gaolin Liang
Summary: This study introduces a new molecular probe for photoacoustic imaging, which shows promising results for early diagnosis of breast cancer. The experimental results demonstrate that the molecular probe enhances the activity of urokinase-type plasminogen activator and holds great potential for application in both in vitro and in vivo settings.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Yinglong Wu, Fang Zeng, Yanli Zhao, Shuizhu Wu
Summary: Optoacoustic imaging is a hybrid biomedical imaging technique that uses contrast agents to generate ultrasound waves in tissues, producing high-resolution images. Multispectral optoacoustic imaging can discriminate signals from different contrast agents and enable specific agent identification in tissues, as well as simultaneous molecular and physiological imaging. Contrast agents play essential roles in optoacoustic imaging, with various new agents being explored and applied in recent years.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Shanshan Lin, Ziyi Cheng, Qifu Li, Rui Wang, Fabiao Yu
Summary: Molecular imaging technologies, especially SERS imaging, offer significant advantages in clinical diagnostics, enabling accurate detection of biomarkers and cellular microenvironment. The integration of multimodal imaging helps achieve more comprehensive and accurate imaging outcomes, showing strong potential in discriminating pathological tissues and surgical navigation.
Review
Chemistry, Inorganic & Nuclear
Wei Quan, Wenhui Song, Qian Zhang, Huawei Huang, Weiying Lin
Summary: The liver, as the metabolic and detoxification center, plays a vital role in various physiological processes. Normal liver function is crucial for maintaining overall health, while abnormal liver function can lead to liver diseases. Early diagnosis of liver diseases is essential for timely treatment. The use of fluorescent probes for detecting biomarkers of liver diseases has provided valuable insights for pathological studies, drug development, and disease diagnosis and treatment in recent years. This review summarizes the progress of fluorescence probes in detecting hepatopathy-related biomarkers and discusses the current challenges and future directions. The development of long wavelength probes, multi-detection probes, quantitative analysis probes, and multi-modal probes is expected to be a popular trend. This review aims to facilitate the development of novel fluorescent probes for disease detection and provide guidance for diagnosis and treatment.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Engineering, Multidisciplinary
Jianguo Ma, Xiangdong Ma, Lijun Xu
Summary: This review paper introduces the advanced ultrasound sensing capabilities required for cutting-edge biomedical ultrasound imaging, and gives a detailed review of state-of-the-art optical ultrasound sensing modalities, which hold significant potential for advanced biomedical ultrasound imaging.
Review
Chemistry, Multidisciplinary
Jing Zhao, Cong Wang, Wanbing Sun, Cong Li
Summary: Excising epileptic foci (EF) is the most efficient approach for treating drug-resistant epilepsy (DRE), but accurate localization of EF is challenging. Finding biomarkers that represent the status of epilepsy and developing probes with high targeting specificity are important for identifying concealed EF. This review summarizes potential biomarkers of EF and classifies them into functional, molecular, and structural aberrances. It also highlights the materials used in fabricating imaging probes and their performance in preclinical and clinical studies. The review discusses perspectives on developing the next generation of probes and the challenges in clinical translation.
ADVANCED MATERIALS
(2022)
Article
Biochemical Research Methods
A. K. Glaser, Y. Wang, J. T. C. Liu
BIOMEDICAL OPTICS EXPRESS
(2016)
Article
Engineering, Biomedical
Xiaochun Xu, Yu Wang, Jialing Xiang, Jonathan T. C. Liu, Kenneth M. Tichauer
PHYSICS IN MEDICINE AND BIOLOGY
(2017)
Article
Engineering, Biomedical
Adam K. Glaser, Nicholas P. Reder, Ye Chen, Erin F. McCarty, Chengbo Yin, Linpeng Wei, Yu Wang, Lawrence D. True, Jonathan T. C. Liu
NATURE BIOMEDICAL ENGINEERING
(2017)
Article
Multidisciplinary Sciences
Yu Wang, Soyoung Kang, Altaz Khan, Gabriel Ruttner, Steven Y. Leigh, Melissa Murray, Sanjee Abeytunge, Gary Peterson, Milind Rajadhyaksha, Suzanne Dintzis, Sara Javid, Jonathan T. C. Liu
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Adam K. Glaser, Nicholas P. Reder, Ye Chen, Chengbo Yin, Linpeng Wei, Soyoung Kang, Lindsey A. Barner, Weisi Xie, Erin F. McCarty, Chenyi Mao, Aaron R. Halpern, Caleb R. Stoltzfus, Jonathan S. Daniels, Michael Y. Gerner, Philip R. Nicovich, Joshua C. Vaughan, Lawrence D. True, Jonathan T. C. Liu
NATURE COMMUNICATIONS
(2019)
Article
Optics
Lindsey A. Barner, Adam K. Glaser, Lawrence D. True, Nicholas P. Reder, Jonathan T. C. Liu
Article
Multidisciplinary Sciences
Chenyi Mao, Min Yen Lee, Jing-Ru Jhan, Aaron R. Halpern, Marcus A. Woodworth, Adam K. Glaser, Tyler J. Chozinski, Leonard Shin, Jeffrey W. Pippin, Stuart J. Shankland, Jonathan Tc Liu, Joshua C. Vaughan
Article
Biochemical Research Methods
Kevin W. Bishop, Adam K. Glaser, Jonathan T. C. Liu
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Biochemical Research Methods
Lindsey A. Barner, Adam K. Glaser, Hongyi Huang, Lawrence D. True, Jonathan T. C. Liu
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Biochemical Research Methods
Adam K. Glaser, Kevin W. Bishop, Lindsey A. Barner, Etsuo A. Susaki, Shimpei I. Kubota, Gan Gao, Robert B. Serafin, Pooja Balaram, Emily Turschak, Philip R. Nicovich, Hoyin Lai, Luciano A. G. Lucas, Yating Yi, Eva K. Nichols, Hongyi Huang, Nicholas P. Reder, Jasmine J. Wilson, Ramya Sivakumar, Elya Shamskhou, Caleb R. Stoltzfus, Xing Wei, Andrew K. Hempton, Marko Pende, Prayag Murawala, Hans-Ulrich Dodt, Takato Imaizumi, Jay Shendure, Brian J. Beliveau, Michael Y. Gerner, Li Xin, Hu Zhao, Lawrence D. True, R. Clay Reid, Jayaram Chandrashekar, Hiroki R. Ueda, Karel Svoboda, Jonathan T. C. Liu
Summary: This article introduces a flexible hybrid light-sheet microscope system that can meet the requirements of different imaging applications, including resolution, sample size, and transparent sample holder material. Experimental results demonstrate that the system can efficiently image sparse axons and perform high-throughput automated imaging of multiple specimens.
Article
Oncology
Yu Winston Wang, Nicholas P. Reder, Soyoung Kang, Adam K. Glaser, Qian Yang, Matthew A. Wall, Sara H. Javid, Suzanne M. Dintzis, Jonathan T. C. Liu
Proceedings Paper
Engineering, Biomedical
Adam K. Glaser, Rongxiao Zhang, Jacqueline Andreozzi, David Gladstone, Brian Pogue
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XXV
(2016)
Proceedings Paper
Microscopy
Jacqueline M. Andreozzi, Rongxiao Zhang, Adam K. Glaser, David J. Gladstone, Lesley A. Jarvis, Brian W. Pogue
PHOTONIC THERAPEUTICS AND DIAGNOSTICS XII
(2016)
