Article
Oncology
Melvin J. Silverstein, Brian Kim, Kevin Lin, Shane Lloyd, Lincoln Snyder, Sadia Khan, Katherine Kramme, Peter Chen
Summary: Randomized trials have shown that risk-adapted intraoperative radiation therapy (IORT) is a safe alternative to whole-breast radiation therapy (WBRT) for low-risk breast cancer patients. Additional WBRT is given to patients with high-risk pathologic characteristics. However, the more WBRT is given, the less we understand the contribution of IORT as a stand-alone treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Stephanie A. Valente, Rahul D. Tendulkar, Sheen Cherian, Chirag Shah, Darrel L. Ross, S. Chace Lottich, Christine Laronga, Kristy K. Broman, Eric D. Donnelly, Kevin P. Bethke, Christina Shaw, Natalie A. Lockney, Aaron Pederson, Ray Rudolph, Michael Hasselle, Pond Kelemen, Ulrich Hermanto, Andrew Ashikari, Song Kang, Richard A. Hoefer, David McCready, Anthony Fyles, Jamie Escallon, Nitin Rohatgi, Jeannine Graves, Gregory Graves, Shawna C. Willey, Eleni Tousimis, Lee Riley, Nimisha Deb, Chao Tu, William Small, Stephen R. Grobmyer
Summary: This study evaluated the North American experience of intraoperative radiation therapy (IORT) for breast cancer treatment and found a 5-year ipsilateral breast tumor recurrence rate of 6.6%, with a rate of 3.9% for patients compliant with endocrine therapy (ET) during primary IORT. These rates differ slightly from recent results of randomized IORT trials and are notably higher than previous studies using whole-breast radiotherapy for early-stage breast cancer.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Andrea Brown, Elizabeth J. Buss, Christine Chin, Gaotong Liu, Shing Lee, Roshni Rao, Brett Taback, Lisa Wiechmann, David Horowitz, Julie C. Choi, Leah M. Katz, Eileen P. Connolly
Summary: This study presents a single-institution experience in the management of invasive breast cancer with targeted intraoperative radiotherapy (TARGIT-IORT). The results show a low rate of ipsilateral breast tumor recurrence (IBTR) when TARGIT-IORT is used in appropriately selected patients. However, the suitability classification may change after surgery, highlighting the need for further investigation and optimization of preoperative patient risk stratification.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Samantha M. Ruff, Oliver Standring, Grace Wu, Anna Levy, Sandeep Anantha, Elliot Newman, Martin S. Karpeh, William Nealon, Gary B. Deutsch, Matthew J. Weiss, Danielle K. DePeralta
Summary: This study compared patients with ampullary, duodenal, and pancreatic head NETs, revealing that ampullary NETs are more likely to present with high-grade tumors and lymph node metastases, indicating a unique underlying biology compared to duodenal and pancreatic head NETs.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Vahid Zangouri, Hamid Nasrollahi, Ali Taheri, Majid Akrami, Peyman Arasteh, Seyed Hassan Hamedi, Masoumeh Ghoddusi Johari, Nazanin Karimaghaee, Aliye Ranjbar, Mohammad Yasin Karami, Sedigheh Tahmasebi, Ahmad Mosalaei, Abdolrasoul Talei
Summary: This study reported experiences with Intraoperative radiation therapy (IORT) among breast cancer patients in a region with limited facilities. A total of 252 patients were included, with 3.1% experiencing recurrence during follow-up. The study highlighted the importance of modified patient selection criteria for IORT in limited resource settings.
Article
Oncology
Jayant Sharad Vaidya, Uma Jayant Vaidya, Michael Baum, Max Kishor Bulsara, David Joseph, Jeffrey S. Tobias
Summary: Targeted intraoperative radiotherapy (TARGIT-IORT) has been widely adopted worldwide and has shown significant impact in breast cancer patients, saving a considerable amount of travel distance and preventing non-breast cancer deaths.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Takanori Kin
Summary: The relationship between anesthesia techniques and cancer recurrence in cancer surgery is not yet clear. Surgical stress and inhalation anesthesia can suppress immune response and increase the risk of cancer recurrence. On the other hand, intravenous anesthesia with propofol and regional anesthesia can protect immune response and decrease the risk of cancer recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Halla Vidarsdottir, Christina Siesing, Bjorn Nodin, Per Jonsson, Jakob Eberhard, Karin Jirstrom, Hans Brunnstrom
Summary: This study investigated prognostic factors in CRC patients treated with pulmonary metastasectomy, including the expression of RBM3. The research found that factors such as age, number of metastases, size of metastasis, disease-free interval, RBM3 score in lung metastasis, and adjuvant chemotherapy were associated with overall survival in these patients.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Christian D. Diehl, Steffi U. Pigorsch, Jens Gempt, Sandro M. Krieg, Silvia Reitz, Maria Waltenberger, Melanie Barz, Hanno S. Meyer, Arthur Wagner, Jan Wilkens, Benedikt Wiestler, Claus Zimmer, Bernhard Meyer, Stephanie E. Combs
Summary: Advancements in systemic cancer management have led to improved survival for multiple types of solid cancer, resulting in an increasing number of patients with brain metastases (BM). Resection is recommended for patients with single brain metastases and controlled primary disease, as well as cases requiring histopathologic diagnosis for cancer management decisions. However, local recurrence rates after surgery are high, necessitating adjuvant local radiation therapy (RT) to improve outcomes. Low-energy X-ray intraoperative radiation therapy (IORT) has emerged as a potential treatment option, offering local ablative treatment with steep dose gradients. This retrospective study describes the effectiveness and safety of IORT in 18 patients with resected brain metastases, supporting previous research findings.
Article
Biology
Alexander Marquardt, Mario Richterstetter, Helge Taubert, Arndt Hartmann, Bernd Wullich, Verena Lieb, Laura Bellut, Sven Wach, Hendrik Apel
Summary: The use of photodynamic diagnostics (PDD) in bladder cancer treatment leads to improved tumor detection rates and reduced recurrence rates. It also reduces the incidence of residual tumors at the initial resection site in extended transurethral resection of the bladder tumor (TURBT) procedures.
Article
Oncology
Jin Wang, Hailin Tang, Kanhua Yin, Xing Li, Xiaoming Xie, Kevin S. Hughes
Summary: After breast-conserving therapy, patients may experience ipsilateral breast tumor recurrence, new primary tumor, or contralateral breast cancer. Patients with true recurrence have poorer survival outcomes compared to those with new primary tumors, while the survival outcomes of contralateral breast cancer are better.
Article
Oncology
Christina Horr, Steven A. Buechler
Summary: Breast cancer exhibits heterogeneity in prognoses and drug responses, with the Breast Cancer Consensus Subtypes (BCCS) providing a classification based on gene expression independent of statistical methodology. Seven BCCS subtypes were identified, including estrogen receptor-positive and negative subtypes, as well as unclassified tumors.
Article
Medicine, General & Internal
Xin Ye Wang, Michael N. Rosen, Rania Chehade, Arjun Sahgal, Sunit Das, Ellen Warner, Refik Saskin, Bo Zhang, Hany Soliman, Kelvin K. W. Chan, Katarzyna J. Jerzak
Summary: This study examines the incidence of brain radiotherapy for brain metastases among patients with metastatic breast cancer. The findings show significant differences in the cumulative incidence and time to development of brain metastases among different breast cancer subtypes. This has important implications for the development of screening programs or preventive interventions targeting specific subtypes.
Article
Otorhinolaryngology
Kaveh Zakeri, Huili Wang, Jung Julie Kang, Anna Lee, Paul Romesser, Nader Mohamed, Daphna Gelblum, Eric Sherman, Lara Dunn, Jay Boyle, Richard Wong, Linda Chen, Yao Yu, C. Jillian Tsai, Sean M. McBride, Nadeem Riaz, Nancy Lee
Summary: In a large cohort of MSGTs treated with PBRT, high rates of locoregional control were observed in short-term follow-up, and the treatment was well tolerated.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Surgery
A. Fancellu, N. Houssami, V Sanna, A. Porcu, C. Ninniri, M. L. Marinovich
Summary: This meta-analysis compared the outcomes of breast-conserving surgery (BCS) versus mastectomy in patients with triple-negative breast cancer (TNBC). The results showed that BCS was associated with lower rates of locoregional recurrence, distant metastasis, and all-cause mortality compared to mastectomy. However, caution should be taken due to potential differences in patient selection for the two surgical options.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Carole Lunny, Areti Angeliki Veroniki, Brian Hutton, Ian White, Jpt Higgins, James M. Wright, Ji Yoon Kim, Sai Surabi Thirugnanasampanthar, Shazia Siddiqui, Jennifer Watt, Lorenzo Moja, Nichole Taske, Robert C. Lorenz, Savannah Gerrish, Sharon Straus, Virginia Minogue, Franklin Hu, Kevin Lin, Ayah Kapani, Samin Nagi, Lillian Chen, Mona Akbar-nejad, Andrea C. Tricco
Summary: This study aimed to develop a risk of bias (RoB) tool for assessing network meta-analysis (NMA) and gather opinions from knowledge users. The Delphi process and knowledge user survey identified the content of the RoB NMA tool and revealed a preference for assessing both individual NMA results and authors' conclusions.
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Oncology
Joseph W. Kim, Rana R. McKay, Marc R. Radke, Shilin Zhao, Mary-Ellen Taplin, Nancy B. Davis, Paul Monk, Leonard J. Appleman, Primo N. Lara, Ulka N. Vaishampayan, Jingsong Zhang, Asit K. Paul, Glenn Bubley, Eliezer M. Van Allen, Serhan Unlu, Ying Huang, Massimo Loda, Geoffrey I. Shapiro, Peter M. Glazer, Patricia M. LoRusso, S. Percy Ivy, Yu Shyr, Elizabeth M. Swisher, Daniel P. Petrylak
Summary: The study investigated the clinical outcomes of combining Cediranib with olaparib in patients with prostate cancer. The results showed that the combination improved radiographic progression-free survival in patients with metastatic castration-resistant prostate cancer compared to olaparib alone. However, it was also associated with a higher incidence of adverse events.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Oncology
Bradley J. Monk, Keiichi Fujiwara, David M. O'Malley, Robert L. Coleman, Iain A. McNeish, Kevin K. Lin, Stephanie Hume, Rebecca S. Kristeleit
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Eve Rodler, Priyanka Sharma, William E. Barlow, Julie R. Gralow, Shannon L. Puhalla, Carey K. Anders, Lori Goldstein, Debu Tripathy, Ursa A. Brown-Glaberman, Thu-Tam Huynh, Christopher S. Szyarto, Andrew K. Godwin, Harsh B. Pathak, Elizabeth M. Swisher, Marc R. Radke, Kirsten M. Timms, Danika L. Lew, Jieling Miao, Lajos Pusztai, Daniel F. Hayes, Gabriel N. Hortobagyi
Summary: PARP inhibitors are effective in germline BRCA1/2-mutated metastatic breast cancer. This study demonstrates that adding veliparib to cisplatin improves progression-free survival in patients with BRCA-like metastatic triple-negative breast cancer.
Article
Oncology
Ann Oluloro, Sarah M. Temkin, Jonathan Jackson, Elizabeth M. Swisher, Liz Sage, Kemi Doll
Summary: This study comprehensively assessed gynecologic cancer clinical trial protocols and found that they lack design elements that provide high value to Black individuals, such as lifestyle risk factors, ancestry, and remuneration. Inclusion of these valued items should be considered in efforts to improve diversity in clinical trial enrollment among Black individuals.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Cell Biology
Colette B. Rogers, Rachel E. Kram, Kevin Lin, Chad L. Myers, Alexandra Sobeck, Eric A. Hendrickson, Anja-Katrin Bielinsky
Summary: Activation of the Fanconi anemia (FA) pathway is crucial for preventing chromosome translocations referred to as "radials" after treatment with mitomycin C (MMC). Radials induced by MMC are dependent on DNA polymerase theta (POLq)-mediated alternative end joining (A-EJ) in FA-deficient cells, specifically involving POL theta and DNA ligase III. Blocking POLq in FA-deficient cells eliminates radials and leads to the accumulation of breaks at common fragile sites. These findings provide mechanistic insights into the formation of radials and offer potential therapeutic strategies for FA pathway-deficient cancers using POLq inhibitors.
Article
Medicine, General & Internal
Olivier Colomban, Elizabeth M. Swisher, Rebecca Kristeleit, Iain McNeish, Ronnie Shapira-Frommer, Sandra Goble, Kevin K. Lin, Lara Maloney, Gilles Freyer, Benoit You
Summary: Mathematical modeling of early CA-125 kinetics can be used as an indicator of rucaparib efficacy in recurrent ovarian carcinoma patients. The KELIM-PARP score is associated with treatment response and progression-free survival. This study suggests the potential use of this strategy in selecting patients for PARPi-based treatment regimens.
Review
Oncology
Ru Li, Mousumi Beto Mukherjee, Zhaosheng Jin, Hengrui Liu, Kevin Lin, Qiuyue Liu, James P. Dilger, Jun Lin
Summary: This meta-analysis examined the effect of general anesthetics on metastasis and recurrence after cancer surgery. It showed that propofol-based total intravenous anesthesia is associated with a lower risk of metastasis/recurrence and lower IL-6 level compared to inhalational anesthesia. Pre-clinical studies confirmed these findings and explored potential mechanisms.
Article
Oncology
Heidi J. Gray, Payel Chatterjee, Rachele Rosati, Lauren R. Appleyard, Grace J. Durenberger, Robert L. Diaz, Hallie A. Swan, Danielle Peretti, Maddy Pollastro, Trevor Ainge, Katannya Kapeli, Shalini Pereira, Astrid L. Margossian, Kalyan Banda, Barbara A. Goff, Elizabeth M. Swisher, Brady Bernard, Christopher J. Kemp, Carla Grandori
Summary: This article describes a remarkable response to targeted therapy in a patient with platinum-resistant, advanced low-grade serous ovarian cancer. Genomic analysis did not provide obvious therapeutic options, but a drug sensitivity assay identified several potential therapies. This case highlights the clinical utility of ex vivo drug testing of patient-derived tumor organoids as a new approach to identify personalized therapies.
NPJ PRECISION ONCOLOGY
(2023)
Editorial Material
Oncology
Melvin J. Silverstein, Brian Kim, Shane Lloyd, Peter Chen, Kevin Lin
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Joyce Y. Wang, Kimberly K. Ma, Daniel J. Reiter, Ana Torvie, Elizabeth M. Swisher
GYNECOLOGIC ONCOLOGY REPORTS
(2023)
Meeting Abstract
Oncology
Bojana Stefanovska, Kevin Lin, Benjamin Troness, Chad Myers, Reuben Harris
Meeting Abstract
Clinical Neurology
David Glickenstein, Avinash Karamchandani, Camille Korbut, Michelle Bang, Alexa Aucoin, Leah Callovini, Kevin Lin, Patricia Haynes
Meeting Abstract
Oncology
Katherine Kramme, Emily Welker, Oana Andreea Raicu, Melvin Silverstein, Sadia Khan, Peter Chen, Kevin Lin, Brian Kim, Shane Lloyd
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Emily Welker, Peter Chen, Sadia Khan, Brian Kim, Katherine Kramme, Kevin Lin, Shane Lloyd, Oana Andreea Raicu, Melvin Silverstein
ANNALS OF SURGICAL ONCOLOGY
(2023)