Article
Medicine, General & Internal
Matthew E. Oster, David K. Shay, John R. Su, Julianne Gee, C. Buddy Creech, Karen R. Broder, Kathryn Edwards, Jonathan H. Soslow, Jeffrey M. Dendy, Elizabeth Schlaudecker, Sean M. Lang, Elizabeth D. Barnett, Frederick L. Ruberg, Michael J. Smith, M. Jay Campbell, Renato D. Lopes, Laurence S. Sperling, Jane A. Baumblatt, Deborah L. Thompson, Paige L. Marquez, Penelope Strid, Jared Woo, River Pugsley, Sarah Reagan-Steiner, Frank DeStefano, Tom T. Shimabukuro
Summary: Based on reports in the US, the risk of myocarditis after receiving mRNA-based COVID-19 vaccines was increased, especially among adolescent males and young men, particularly after the second dose. This risk should be considered in the context of the benefits of COVID-19 vaccination.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Immunology
Patrick Sean Sullivan, Aaron J. Siegler, Kayoko Shioda, Eric W. Hall, Heather Bradley, Travis Sanchez, Nicole Luisi, Mariah Valentine-Graves, Kristin N. Nelson, Mansour Fahimi, Amanda Kamali, Charles Sailey, Benjamin A. Lopman
Summary: One in 8 US adults had been infected with severe acute respiratory syndrome coronavirus 2 by late October 2020; however, few had been accounted for in public health reporting.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Lindsey Wang, Pamela B. Davis, David C. Kaelber, Rong Xu
Summary: This study found that vaccinated older adults with dementia have an increased risk of COVID-19 breakthrough infections, particularly those with LBD, VD, AD, and MCI. The incidence rate of breakthrough infections has been gradually increasing since vaccination began, with a more pronounced acceleration after May 2021. The risk of hospitalization after breakthrough infections also varied among different dementia subtypes.
ALZHEIMERS & DEMENTIA
(2023)
Article
Immunology
Alison Stargel, Melanie M. Taylor, Shelley Zansky, Kimberly Spencer, Matthew Hogben, Alvin Shultz
Summary: This study describes the nationwide efforts of US health departments in conducting case investigation and contact tracing activities for COVID-19. The results show that despite case surges and fluctuating workloads, the coverage and performance of CI/CT activities remain good.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Leigh Ellyn Preston, Araceli Rey, Simone Dumas, Andrea Rodriguez, Alida M. Gertz, Kristin C. Delea, Francisco Alvarado-Ramy, Deborah L. Christensen, Clive Brown, Tai -Ho Chen
Summary: This study examined trends in the number of COVID-19 infectious travelers in relation to vaccination rates and overall SARS-CoV-2 cases in the United States. The majority of travelers were asymptomatic during travel, indicating unknowing transmission. During periods of high community transmission, vaccination and mask-wearing are important for reducing the risk of transmission.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Lydia E. Calamari, Ashley H. Tjaden, Sharon L. Edelstein, William S. Weintraub, Roberto Santos, Michael Gibbs, Johnathan Ward, Michele Santacatterina, Alain G. Bertoni, Lori M. Ward, Sharon Saydah, Ian D. Plumb, Michael S. Runyon
Summary: This study investigated self-reported mask use among participants in the COVID-19 Community Research Partnership (CRP) and found that mask use was higher among vaccinated participants and those aged 65 years and older, female, racial or ethnic minority group, and healthcare workers. Lower mask use was associated with a history of self-reported prior COVID-19 illness.
PREVENTIVE MEDICINE REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Andrew Geller, Daniel S. Budnitz, Heather Dubendris, Radhika Gharpure, Minn Soe, Hsiu Wu, Elizabeth J. Kalayil, Andrea L. Benin, Suchita A. Patel, Megan C. Lindley, Ruth Link-Gelles
Summary: Monitoring COVID-19 vaccination coverage among nursing home residents and staff is crucial for patient safety policies. The study found a high correlation between vaccination data reported by pharmacies and nursing homes, and the coverage rates have been increasing over time.
PUBLIC HEALTH REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Amy Heinzerling, Alyssa Nguyen, Matt Frederick, Elena Chan, Kathryn Gibb, Andrea Rodriguez, Jessie Wong, Erin Epson, James Watt, Barbara Materna, Seema Jain
Summary: The study describes the industries in California with the highest burden of COVID-19 outbreaks. The healthcare and social assistance sector had the most outbreaks and outbreak-associated cases, followed by the retail trade and manufacturing sectors. The demographics of outbreak-associated cases varied across industries.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Chemistry, Applied
Paul Knochel, Kevin P. Cole
Summary: The tribute to Professor Victor Snieckus focuses on his significant contributions to the field of organic chemistry and directed ortho metalation technology.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Immunology
Christopher J. Floyd, Grace E. Joachim, Matthew L. Boulton, Jon Zelner, Abram L. Wagner
Summary: After the relaxation of mask guidelines, the rate of mask wearing decreased, both among vaccinated individuals and unvaccinated individuals. Vaccinated individuals had higher odds of wearing a mask at work/school (OR: 2.35, 95% CI: 1.82, 3.04) and at a grocery store (OR: 1.65, 95% CI: 1.29, 2.11) compared to the unvaccinated.
EXPERT REVIEW OF VACCINES
(2022)
Article
Public, Environmental & Occupational Health
Summer E. Galloway, Prabasaj Paul, Duncan R. MacCannell, Michael A. Johansson, John T. Brooks, Adam MacNeil, Rachel B. Slayton, Suxiang Tong, Benjamin J. Silk, Gregory L. Armstrong, Matthew Biggerstaff, Vivien G. Dugan
Summary: The B.1.1.7 variant poses an increased threat to public health, which requires stronger mitigation strategies and higher vaccination coverage. Strengthening genomic surveillance systems and expanding sequencing efforts will enable timely identification and response to concerning variants.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2021)
Article
Immunology
Allison T. Chamberlain, Kathleen E. Toomey, Heather Bradley, Eric W. Hall, Mansour Fahimi, Benjamin A. Lopman, Nicole Luisi, Travis Sanchez, Cherie Drenzek, Kayoko Shioda, Aaron J. Siegler, Patrick Sean Sullivan
Summary: Using data from a probability survey of households in Georgia, United States, it was estimated that 1.3 million adults aged 18 and above had been infected with SARS-CoV-2 by November 16, 2020. One in four infections were reported and the infection fatality ratio was 0.78%. The study found that reported COVID-19 cases underestimated the true number of infections and data on asymptomatic infections are needed. The cumulative incidence of SARS-CoV-2 infections adjusted for antibody waning was estimated to be 16.1%, with higher seropositivity rates observed among non-Hispanic black and Hispanic adults compared to non-Hispanic white adults.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Liesl M. Hagan, Charles Dusseau, Michael Crockett, Tami Rodriguez, Michael J. Long
Summary: The Federal Bureau of Prisons (BOP) in the United States carried out COVID-19 vaccine distribution operations from December 2020 to April 2021, achieving vaccination coverage rates of 50.2% for staff and 64.2% for incarcerated individuals. Vaccination coverage in BOP was comparable to the overall adult population in the states and territories where BOP facilities are located. Factors associated with lower vaccination acceptance among incarcerated individuals included younger age, female sex, non Hispanic Black and Asian race/ethnicity, and few underlying medical conditions, while higher acceptance was associated with prior SARS-CoV-2 infection and being born outside the United States.
Article
Immunology
Jeremy A. W. Gold, Stacey Adjei, Adi V. Gundlapalli, Ya-Lin A. Huang, Tom Chiller, Kaitlin Benedict, Mitsuru Toda
Summary: Hospitalizations due to fungal infections in the US increased by 8.5% annually from 2019 to 2021. In 2020-2021, patients hospitalized with COVID-19-associated fungal infections had a higher in-hospital mortality rate (48.5%) compared to those with non-COVID-19-associated fungal infections (12.3%). Enhanced surveillance of fungal diseases is necessary, especially during respiratory virus pandemics.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Patricia Mouta Nunes de Oliveira, Daniela P. Mendes-de-Almeida, Victor Bertollo Gomes Porto, Catherine Crespo Cordeiro, Gabriellen Vitiello Teixeira, Renata Saraiva Pedro, Paulo Roberto Gomes Takey, Leticia Kegele Lignani, Janaina Reis Xavier, Vitor Cardoso Doria da Gamaa, Luiz Amorim Filho, Barbara Emoingt Furtado, Andre Santa Maria, Tiago Dahrug Barros, Livia Neves Waite Freitas, Taina dos Santos Pereira, Debora Lima Abreu, Michael Bernardes Ramos, Caroline Gabe, Donald Arnold, James William Smith, Ishac Nazy, Maria de Lourdes de Sousa Maia
Summary: This case series study describes vaccine-induced immune thrombotic thrombocytopenia (VITT) cases following COVID-19 vaccination in Brazil, including ChAdOx1 nCoV-19, Ad26.COV2.S, and BNT162b2 vaccines, and describes their clinical and laboratory characteristics. The study findings suggest that VITT is a very rare but serious adverse event following COVID-19 immunization.
Article
Oncology
Shannon C. Walker, Jennifer R. Reppucci, Mary Ann Thompson, Scott C. Borinstein, Debra L. Friedman, Sara Zarnegar-Lumley
Summary: This article reports two cases of isolated central nervous system relapse in patients with B-cell acute lymphoblastic leukemia following confirmed infection with severe acute respiratory syndrome coronavirus 2. In addition to individual and disease factors, delays in therapy and immune system modulation caused by severe acute respiratory syndrome coronavirus 2 may explain these cases of relapsed B-cell acute lymphoblastic leukemia.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Hematology
Brooke Sadler, Charles G. Minard, Gabe Haller, Christina A. Gurnett, Sarah H. O'Brien, Allison Wheeler, Shilpa Jain, Mutka Sharma, Ayesha Zia, Roshni Kulkarni, Eric Mullins, Margaret Ragni, Robert Sidonio, Jennifer E. Dietrich, Peter A. Kouides, Jorge Di Paola, Lakshmi Srivaths
Summary: Adolescents with low VWF levels and HMB have an excess of rare nonsynonymous and pathogenic variants in genes associated with bleeding disorders and anemia. These variants may partially explain the bleeding phenotype observed in patients. Identifying patients with these variants can improve risk stratification and patient outcomes.
Article
Psychology, Developmental
Misha Khalighi, Allison P. Wheeler, Oluyemisi A. Adeyemi-Fowode, Peter A. Kouides, Ramon A. Durazo-Arvizu, Kristina Haley, Candice M. Dersch, Angela C. Weyand, Maureen K. Baldwin, Claudia Borzutzky
Summary: This study compared patient outcomes in adolescents with and without inherited bleeding disorders (BD) who underwent treatment for heavy menstrual bleeding (HMB) using the 52-mg levonorgestrel-releasing intrauterine system (52-LNG-IUS) within 12 months of insertion. The findings showed that both groups experienced improvement in bleeding outcomes and had similar rates of spontaneous expulsion.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Hematology
Edward L. Snyder, Allison P. Wheeler, Majed Refaai, Claudia S. Cohn, Jessica Poisson, Magali Fontaine, Mary Sehl, Ajay K. Nooka, Lynne Uhl, Philip Spinella, Maly Fenelus, Darla Liles, Thomas Coyle, Joanne Becker, Michael Jeng, Eric A. Gehrie, Bryan R. Spencer, Pampee Young, Andrew Johnson, Jennifer J. O'Brien, Gary J. Schiller, John D. Roback, Elizabeth Malynn, Ronald Jackups, Scott T. Avecilla, Jin-Sying Lin, Kathy Liu, Stanley Bentow, Ho-Lan Peng, Jeanne Varrone, Richard J. Benjamin, Laurence M. Corash
Summary: Compared with conventional platelet components (CPC), pathogen reduction of platelet components (PRPC) shows a higher level of safety and significantly reduces the incidence of treatment-emergent assisted mechanical ventilation (TEAMV).
Article
Medicine, Research & Experimental
Shannon C. Walker, Benjamin French, Ryan Moore, Henry J. Domenico, Jonathan P. Wanderer, Sreenivasa Balla, C. Buddy Creech, Daniel W. Byrne, Allison P. Wheeler
Summary: The ongoing pragmatic randomized trial aims to assess a risk-prediction tool used to identify hospitalized pediatric patients at elevated risk of developing HA-VTE.
Letter
Hematology
Jeremy W. Jacobs, Brian D. Adkins, Allison P. Wheeler, Jennifer C. Yui, Garrett S. Booth
Review
Hematology
Imo J. Akpan, Beverley J. Hunt
Summary: This article reviews the prevention and management of thrombotic problems in hospitalized patients, focusing on the role of clinical hematologists. The role of clinical hematologists in thrombosis practice varies worldwide, and this variation is discussed in the article. Hospital-associated venous thromboembolism (VTE), or hospital-associated thrombosis (HAT), is a common patient safety issue, and VTE risk can be significantly reduced through evidence-based thromboprophylaxis and risk assessment. The use of direct oral anticoagulants (DOACs) is common in hospitalized patients, especially older patients, for stroke prevention in atrial fibrillation, and their perioperative management and urgent reversal are important considerations. The article also discusses other complex interventions requiring anticoagulation and the unique challenges associated with uncommon high-risk thrombophilias during hospitalization.
Letter
Hematology
Glaivy Batsuli, Allison P. Wheeler, Angela C. Weyand, Robert F. Sidonio, Guy Young
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Hematology
Allison P. Wheeler, Ming Y. Lim, Patricia S. Huguelet, Julie Jaffray, Janice M. Staber, Kerry Funkhouser, Shannon L. Carpenter, Angela C. Weyand
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Oncology
George Mellgard, Elina Stoffel, Alissa Michel, Fatima Iqbal, Anthony Provenzano, Imo J. Akpan, Jennifer Amengual, Barbara Pro
LEUKEMIA & LYMPHOMA
(2023)
Article
Hematology
Jeremy W. Jacobs, Brian D. Adkins, Shannon C. Walker, Garrett S. Booth, Allison P. Wheeler
Summary: The incidence of coagulation factor inhibitors in patients with SARS-CoV-2 vaccination and infection appears to be similar to the general population. Inhibitor specificity for factor VIII was most common, and two patients died due to hemorrhage. Recognizing inhibitors is important due to the importance of heparin therapy in treating hospital patients.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)