Microfluidics‐Assisted Engineering of pH/Enzyme Dual‐Activatable ZIF@Polymer Nanosystem for Co‐Delivery of Proteins and Chemotherapeutics with Enhanced Deep‐Tumor Penetration

Efficient intracellular delivery of p53 protein by engineered protein crystals restores tumor suppressing function in vivo

(2021) Zaofeng Yang et al.   BIOMATERIALS

A Simple and Quick Method for Loading Proteins in Extracellular Vesicles

(2021) Sara Busatto et al.   Pharmaceuticals

Protein Engineering Strategies for Improved Pharmacokinetics

(2021) Aurélie Rondon et al.   ADVANCED FUNCTIONAL MATERIALS

Coordination-driven assembly of proteins and nucleic acids in a single architecture for carrier-free intracellular co-delivery

(2021) Congli Wang et al.   Nano Today

The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials

(2020) Evelyn Ploetz et al.   ADVANCED FUNCTIONAL MATERIALS

Hypoxia‐instructed pro‐protein therapy assisted with self‐catalyzed nanozymogen

(2020) Xudong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Multistage Cooperative Nanoplatform Enables Intracellular Co‐Delivery of Proteins and Chemotherapeutics for Cancer Therapy

(2020) Peng Zhang et al.   ADVANCED MATERIALS

Active Transportation of Liposome Enhances Tumor Accumulation, Penetration, and Therapeutic Efficacy

(2020) Guowei Wang et al.   Small

On-Demand Detaching Nanosystem for the Spatiotemporal Control of Cancer Theranostics

(2019) Tianzhi Liu et al.   ACS Applied Materials & Interfaces

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

A Virus‐Mimicking pH‐Responsive Acetalated Dextran‐Based Membrane‐Active Polymeric Nanoparticle for Intracellular Delivery of Antitumor Therapeutics

(2019) Saowanee Wannasarit et al.   ADVANCED FUNCTIONAL MATERIALS

Rational Design of Nanocarriers for Intracellular Protein Delivery

(2019) Xiaofei Qin et al.   ADVANCED MATERIALS

Effective and Selective Anti-Cancer Protein Delivery via All-Functions-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering

(2018) Hua He et al.   ADVANCED FUNCTIONAL MATERIALS

Biomineralized Metal-Organic Framework Nanoparticles Enable Intracellular Delivery and Endo-Lysosomal Release of Native Active Proteins

(2018) Ting-Ting Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controllable synthesis of functional nanoparticles by microfluidic platforms for biomedical applications – a review

(2017) Junping Ma et al.   LAB ON A CHIP

Co-delivery of chemotherapeutics and proteins for synergistic therapy

(2016) Chaoliang He et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanotechnology for protein delivery: Overview and perspectives

(2016) Mikyung Yu et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced Intracellular Protein Transduction by Sequence Defined Tetra-Oleoyl Oligoaminoamides Targeted for Cancer Therapy

(2015) Peng Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Nanogel-Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo-Protein Combination Therapy

(2015) Xilong Wu et al.   ADVANCED FUNCTIONAL MATERIALS

A Versatile and Robust Microfluidic Platform Toward High Throughput Synthesis of Homogeneous Nanoparticles with Tunable Properties

(2015) Dongfei Liu et al.   ADVANCED MATERIALS

Gel-Liposome-Mediated Co-Delivery of Anticancer Membrane-Associated Proteins and Small-Molecule Drugs for Enhanced Therapeutic Efficacy

(2014) Tianyue Jiang et al.   ADVANCED FUNCTIONAL MATERIALS

Stimuli-responsive nanomaterials for therapeutic protein delivery

(2014) Yue Lu et al.   JOURNAL OF CONTROLLED RELEASE

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

(2012) Jason Park et al.   NATURE MATERIALS

Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells

(2011) Feng Wang et al.   ACS Nano

Acid-Degradable Cationic Dextran Particles for the Delivery of siRNA Therapeutics

(2011) Jessica L. Cohen et al.   BIOCONJUGATE CHEMISTRY

Tailor-Made Dual pH-Sensitive Polymer–Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

(2011) Jin-Zhi Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Charge-Conversional Polyionic Complex Micelles-Efficient Nanocarriers for Protein Delivery into Cytoplasm

(2009) Yan Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic Applications

(2008) Eric M. Bachelder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY