Article
Urology & Nephrology
Behzad Najafian, Mark A. Lusco, Charles E. Alpers, Agnes B. Fogo
Summary: Kidney biopsy is crucial for diagnosing kidney diseases, and it is important to obtain adequate samples and interpret them correctly. This article reviews the allocation and processing of kidney biopsies, as well as the diagnosis and interpretation of different lesions.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Wilfried Mullens, Jeroen Dauw, Pieter Martens, Evelyne Meekers, Petra Nijst, Frederik H. Verbrugge, Fabien Chenot, Samer Moubayed, Riet Dierckx, Philippe Blouard, David Derthoo, Walter Smolders, Bavo Ector, Michael Hulselmans, Stijn Lochy, David Raes, Emeline Van Craenenbroeck, Hans Vandekerckhove, Pieter-Jan Hofkens, Kathleen Goossens, Anne-Catherine Pouleur, Michel De Ceuninck, Laurence Gabriel, Philippe Timmermans, Edgard A. Prihadi, Frederik Van Durme, Michel Depauw, Delphine Vervloet, Els Viaene, Jean-Luc Vachiery, Katrien Tartaglia, Jozine M. Ter Maaten, Liesbeth Bruckers, Walter Droogne, Pierre Troisfontaines, Kevin Damman, Johan Lassus, Alexandre Mebazaa, Gerasimos Filippatos, Frank Ruschitzka, Matthias Dupont
Summary: The ADVOR trial recruited 519 acute heart failure patients to investigate the efficacy of acetazolamide in improving decongestion on top of standard loop diuretics. The study found that the participants were older with higher levels of NT-proBNP, reflecting the real-world clinical situation.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Medicine, General & Internal
Federico Nalesso, Federica Stefanelli, Leda Cattarin, Mariaelena Billo, Maddalena Gnappi, Gabriele Partesano, Martina Cacciapuoti, Luciano Babuin, Lorenzo A. A. Calo
Summary: Slow continuous ultrafiltration (SCUF) is a therapy that can reduce fluid overload in heart failure patients resistant to diuretics. A clinical case of SCUF-RCA demonstrated the successful use of a pre-existing multi-lumen CVC for 10 hours of treatment. The patient had hemodynamic improvement and increased diuresis after SCUF-RCA. This technique may be useful in treating fluid overload in outpatients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Laura Ortmann, Teri J. Mauch, Jean Ballweg
Summary: This study examined the use of sodium chloride supplementation in children prescribed diuretics. The findings suggest that sodium chloride supplementation increased fluid balance without affecting patient weight or diuretic dose.
Review
Critical Care Medicine
Sine Wichmann, Marija Barbateskovic, Ning Liang, Theis Skovsgaard Itenov, Rasmus Ehrenfried Berthelsen, Jane Lindschou, Anders Perner, Christian Gluud, Morten Heiberg Bestle
Summary: This study systematically reviewed the benefits and harms of loop diuretics, the predominant treatment for fluid overload in intensive care unit (ICU) patients. The results showed that there was no significant difference in mortality rate, but fewer serious adverse events were observed in the loop diuretic group. However, the evidence on the effects of loop diuretics on these outcomes is very uncertain.
ANNALS OF INTENSIVE CARE
(2022)
Article
Genetics & Heredity
Lauren J. Massingham, Sabrina Nunez, Jonathan A. Bernstein, David P. Gardner, Aditi Shah Parikh, Erin T. Strovel, Fabiola Quintero-Rivera
Summary: This article introduces the development of genetics and genomics and the application of genomic information in clinical practice, emphasizing the need for healthcare professionals to stay updated on new genetic discoveries and technologies and apply these advances in practice. The article presents the 2022 core competencies in medical genetics as a guide for medical school leadership and educators in curriculum development, implementation, and assessment, fostering the knowledge, skills, and behaviors required in medical practice.
GENETICS IN MEDICINE
(2022)
Letter
Critical Care Medicine
Koichi Kitamura, Koichi Hayashi, Shigeki Fujitani, Raghavan Murugan, Toshihiko Suzuki
Summary: A recent global survey has shown international diversity in net ultrafiltration (UFNET) practices for treating fluid overload in critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT). In Japan, the maximum doses of furosemide used before determining diuretic resistance are lower compared to global prescription practices, with UFNET initiated earlier. However, practitioners in Japan evaluate fluid balance over a longer time interval. This characterization of RRT in critically ill patients in Japan may lead to more appropriate approaches for successful AKI treatment.
JOURNAL OF INTENSIVE CARE
(2021)
Review
Medicine, General & Internal
Sharad Patel, Adam Green, Sandhya Ashokumar, Andrew Hoke, Jean-Sebastien Rachoin
Summary: This review discusses new methods for assessing volume status, including lung ultrasound, inferior vena cava ultrasound, venous excess ultrasound score, and cardiac echocardiographic techniques, which can provide more accurate and objective assessment of fluid status.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Jean-Maxime Cote, Josee Bouchard, Patrick T. Murray, William Beaubien-Souligny
Summary: Continuous loop-diuretic infusion and combinations of loop diuretics with thiazide or carbonic anhydrase inhibitors significantly increased urine output, resulting in negative fluid balance and weight loss. Conversely, intravenous albumin administration was associated with fluid gain.
JOURNAL OF CRITICAL CARE
(2021)
Article
Medicine, General & Internal
Emilie Zeuthen, Sine Wichmann, Martin Schonemann-Lund, Mikko J. J. Jarvisalo, Rebecka Rubenson-Wahlin, Martin I. I. Sigurosson, Erling Holen, Morten H. H. Bestle
Summary: Practices among Nordic ICU physicians in assessing, diagnosing, and treating fluid overload reveal variability in practice. A 5% increase in body weight is considered the minimum to support the diagnosis of fluid overload. Clinical examination findings are preferred for assessing, diagnosing, and treating fluid overload, with diuretics being the preferred treatment modality.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Alexandre O. Gerard, Audrey Laurain, Antoine Sicard, Diane Merino, Atul Pathak, Milou-Daniel Drici, Guillaume Favre, Vincent L. M. Esnault
Summary: This article discusses the importance of diuretics in patients with diabetes mellitus, emphasizing the use of a combined diuretics strategy to improve renal and cardiac protection.
Article
Gastroenterology & Hepatology
Jesse Davidson, Matthew Strand, Darren Cullinan, Meranda Scherer, Amen Zafar, John Martinie, Dionisios Vrochides, William Chapman, Majella Doyle, Adeel Khan
Summary: This study surveyed the expectations and perceptions of incoming AHPBA fellows in 2022 regarding robotics training. The results showed that the participants had limited experience with robotics prior to fellowship, but most agreed that robotics training had a positive impact on their career prospects and marketability. However, the majority of participants were not satisfied with the current robotics training and lacked a formal training curriculum.
Article
Pediatrics
Mariah L. Wright, Brett G. Klamer, Elizabeth Bonachea, John D. Spencer, Jonathan L. Slaughter, Tahagod H. Mohamed
Summary: Fluid overload in neonates can lead to poor outcomes, but diuretics may help reduce the rates of mechanical ventilation and mortality. A retrospective study of preterm neonates in a level IV NICU from 2014-2020 found that fluid balance distribution varied by gestational age, and higher peak fluid balance percentages were associated with increased odds of mechanical ventilation and mortality. The use of diuretics was more common in neonates with younger gestational age, smaller birth weight, positive fluid balance, and those on mechanical ventilation.
PEDIATRIC NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jose Civera, Rafael de la Espriella, Raquel Heredia, Gema Minana, Enrique Santas, Adriana Conesa, Anna Mollar, Clara Sastre, Ana Martinez, Amparo Villaescusa, Julio Nunez
Summary: This study evaluated the efficacy and safety of subcutaneous furosemide in patients with WHF, showing that administration of subcutaneous furosemide led to a sustained increase in urinary sodium levels and evidence of decongestion at 72 hours and 30 days. The study concluded that subcutaneous furosemide is an effective and safe outpatient diuretic strategy for managing congestion.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Medicine, General & Internal
Michael D. Anestis, Jayna Moceri-Brooks, Rachel L. Johnson, Craig J. Bryan, Ian H. Stanley, Jessica T. Buck-Atkinson, Justin C. Baker, Marian E. Betz
Summary: This survey study found that gun safes were the most frequently used locking device by firearm owners in the US. The most common obstacles were disbelief in the necessity of locks and concerns about access speed. Child access was the most common reason for considering locking unlocked firearms. The findings suggest that increasing secure storage may require addressing these obstacles and clarifying the risks associated with unlocked firearms.
