TLR8 / TLR7 dysregulation due to a novel TLR8 mutation causes severe autoimmune hemolytic anemia and autoinflammation in identical twins

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

(2021) Takaki Asano et al.   Science Immunology

Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

(2020) Stuart G. Tangye et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain-of-function

(2020) Jahnavi Aluri et al.   BLOOD

Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study

(2019) Monika Brüggemann et al.   LEUKEMIA

TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection

(2019) Marine de Marcken et al.   Science Signaling

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands

(2018) Zhikuan Zhang et al.   Cell Reports

Differences in clinical features observed between childhood-onset versus adult-onset systemic lupus erythematosus

(2017) Pravesh Kumar Bundhun et al.   MEDICINE

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8

(2016) Hiromi Tanji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GeneMatcher: A Matching Tool for Connecting Investigators with an Interest in the Same Gene

(2015) Nara Sobreira et al.   HUMAN MUTATION

Toll-like receptor 8 deletion accelerates autoimmunity in a mouse model of lupus through a Toll-like receptor 7-dependent mechanism

(2015) Ngoc Lan Tran et al.   IMMUNOLOGY

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition ofStreptococcus pyogenes

(2015) Tatjana Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous

(2015) Ratnadeep Mukherjee et al.   Scientific Reports

TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice

(2014) B. Desnues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA recognition by human TLR8 can lead to autoimmune inflammation

(2013) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

(2013) H. Tanji et al.   SCIENCE

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

(2012) D. C. Koboldt et al.   GENOME RESEARCH

Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis

(2011) Markus H. Hoffmann et al.   JOURNAL OF AUTOIMMUNITY

UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling

(2011) Hiroki Itoh et al.   PLoS One

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

(2010) Capucine Picard et al.   MEDICINE

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation

(2009) A. Larange et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tregs are regulated by cytokines: Implications for autoimmunity

(2008) Antonio La Cava   AUTOIMMUNITY REVIEWS

Yaaautoimmune phenotypes are conferred by overexpression of TLR7

(2008) Anna‐Marie Fairhurst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

(2008) Pui Y. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE