Article
Geriatrics & Gerontology
A. Zarina Kraal, Hailey L. Dotterer, Neika Sharifian, Emily P. Morris, Ketlyne Sol, Afara B. Zaheed, Jacqui Smith, Laura B. Zahodne
Summary: The study found that physical activity in early and mid-adulthood is associated with memory level and decline in later life. Early adulthood physical activity indirectly influences later-life memory level through mid-adulthood physical activity and hypertension rates in later life, with hypertension serving as a key mediator of these effects.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Tomas Jorda-Siquier, Melina Petrel, Vladimir Kouskoff, Una Smailovic, Fabrice Cordelieres, Susanne Frykman, Ulrike Mueller, Christophe Mulle, Gael Barthet
Summary: The distribution of amyloid precursor protein (APP) and its fragments is altered in Alzheimer's disease (AD), leading to their accumulation around amyloid plaques with presynaptic proteins. This finding is associated with histopathological features and familial AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Brian O. Orr, Richard D. Fetter, Graeme W. Davis
Summary: This study demonstrates that presynaptic homeostatic plasticity (PHP) is regulated through the assembly and physical expansion of presynaptic signaling foci. Integrins and Semaphorin2b/PlexinB signaling play important roles in this process. This research provides a dynamic framework for understanding the initiation, potentiation, and limitation mechanisms of PHP.
Article
Multidisciplinary Sciences
Christine St. W. Laurent, Sanna Lokhandwala, Tamara Allard, Angela Ji, Tracy Riggins, Rebecca M. C. Spencer
Summary: This study aimed to investigate the relationship between nap habituality and sedentary time and physical activity in preschool-aged children. The study also explored the association between nap physiology and movement behaviors, as well as the impact of missing a nap on movement behaviors. The findings suggest that there is no significant relationship between naps and movement behaviors in children.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
John Travers, Roman Romero-Ortuno, John Langan, Fergal MacNamara, Darren McCormack, Christopher McDermott, Jude McEntire, Joanne McKiernan, Sean Lacey, Peter Doran, Dermot Power, Marie-Therese Cooney
Summary: This study examined the effectiveness of an optimised exercise and dietary protein intervention in combating frailty and improving resilience in older people. The combination of exercise and dietary protein significantly reduced frailty and improved self-reported health after 3 months of intervention.
Article
Psychology, Biological
Stamatis Mourtakos, Georgia Vassiliou, Christos Papageorgiou, Konstantinos Kontoangelos, Anastasios Philippou, Fragkiskos Bersimis, Nikolaos Geladas, Michael Koutsilieris, Labros S. Sidossis, Charalampos Tsirmpas, Charalabos Papageorgiou
Summary: The study found that while HN-SEALs performed similarly to the control group in cognitive and emotion tasks, they exhibited significantly lower HRV levels. Additionally, HN-SEALs demonstrated higher levels of somatization, anxiety and neuroticism in psychometric evaluations compared to the healthy controls. Overall, the findings suggest that HN-SEALs display flexibility in autonomic regulation during cognitive and emotional tasks, highlighting the importance of HRV measurement in understanding psychophysiological resilience.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Endocrinology & Metabolism
Travis Anderson, Gail Corneau, Laurie Wideman, Kari Eddington, Suzanne Vrshek-Schallhorn
Summary: The study found that prior day sleep duration and physical activity levels can interact to predict the cortisol awakening response (CAR) the following morning, with short sleep duration and high levels of physical activity resulting in an augmented CAR. The effects of sleep and physical activity on CAR demonstrate an interactive effect.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Physiology
Liisa Kuula, Jari Lipsanen, Timo Partonen, Jaakko Kauramaki, Risto Halonen, Anu-Katriina Pesonen
Summary: Circadian rhythms are related to physical activity levels in adolescents, with lower average values and higher amplitudes of circadian rhythms associated with higher levels of physical activity. Adolescents with delayed sleep phase and longer sleep duration are more likely to engage in sedentary behavior.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Ekjyot K. Saini, Brian T. Gillis, Lori Elmore-Staton, Joseph A. Buckhalt, Mona El-Sheikh
Summary: Self-esteem moderates the longitudinal associations between sleep quality and cognitive functioning in children. Children with better sleep quality and higher self-esteem perform better in cognitive functioning compared to other children in the sample.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Cell Biology
Anu G. Nair, Paola Muttathukunnel, Martin Mueler
Summary: The study demonstrates that different receptor perturbations at the Drosophila neuromuscular junction result in different responses, with some receptor inhibitions not compensated by PHP while others induce compensatory PHP through distinct signaling pathways. This highlights the diversity of homeostatic signaling mechanisms, showing that synapses respond differentially to similar activity impairments and achieve homeostatic compensation via different pathways.
Article
Cell Biology
Johannes Alexander Mueller, Julia Betzin, Jorge Santos-Tejedor, Annika Mayer, Ana-Maria Oprisoreanu, Kasper Engholm-Keller, Isabelle Paulussen, Polina Gulakova, Terrence Daniel McGovern, Lena Johanna Gschossman, Eva Schoenhense, Jesse R. Wark, Alf Lamprecht, Albert J. Becker, Ashley J. Waardenberg, Mark E. Graham, Dirk Dietrich, Susanne Schoch
Summary: The stability of synaptic function relies on the ability of synapses to adjust their strength according to neuronal activity levels. This study reveals that the phosphorylation status of the active-zone protein RIM1 is crucial for synaptic glutamate release. Furthermore, the protein kinase SRPK2 and RIM1 are shown to play a role in the homeostatic balance of synaptic coupling in neuronal networks.
Article
Psychology, Clinical
Annabel Vreeker, Scott C. Fears, Susan K. Service, Lucia Pagani, Joseph S. Takahashi, Carmen Araya, Xinia Araya, Julio Bejarano, Maria C. Lopez, Gabriel Montoya, Claudia Patricia Montoya, Terri M. Teshiba, Javier Escobar, Rita M. Cantor, Carlos Lopez-Jaramillo, Gabriel Macaya, Julio Molina, Victor I. Reus, Chiara Sabatti, Roel A. Ophoff, Nelson B. Freimer, Carrie E. Bearden
Summary: Increased physical activity and improved sleep were associated with larger brain size, better cognitive function, and more stable temperament in both BP-I patients and their non-BP-I relatives. Pleiotropy of several actigraphy-behavior and actigraphy-brain phenotypes was also found, suggesting shared genetic influences between these traits.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Minjee Kim, Eric M. Liotta, Matthew B. Maas, Rosemary Braun, Blas Garcia-Canga, Daniel R. Ganger, Daniela P. Ladner, Kathryn J. Reid, Phyllis C. Zee
Summary: The study found that cognitive impairment is common in patients with liver cirrhosis, and their sleep quality is worse compared to healthy controls. Patients with cirrhosis exhibit fragmented rest-activity rhythms and abnormal light exposure patterns. Poor working memory and processing speed are associated with lower daytime activity levels, higher rest-activity fragmentation, lower day-to-day stability, and greater nocturnal light exposure in cirrhosis patients.
Article
Clinical Neurology
Luna Geagea, Pia Maria Ghanime, Samer El Hayek, Firas Kobeissy, Hani Tamim, Martine Elbejjani, Farid Talih
Summary: This pilot study aimed to evaluate the impact of Cognitive Behavioral Therapy for insomnia (CBTi) on individuals with cannabis use disorder and insomnia, as well as its effect on serum inflammatory markers related to insomnia symptoms. The results showed that CBTi was effective in both short-term and long-term treatment of insomnia and comorbid anxiety/depression in individuals who regularly use cannabis. Additionally, a potential added benefit of CBTi was a reduction in cannabis consumption and inflammatory serum biomarkers.
Article
Clinical Neurology
David T. Edgar, Nicholas D. Gill, Christopher Martyn Beaven, Jennifer L. Zaslona, Matthew W. Driller
Summary: Sleeping more than 6:15 hr:min per night over 6 weeks was associated with small benefits to aspects of physical performance, and moderate to large benefits on subjective wellbeing measures when compared with sleeping < 6:15 hr:min.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Clinical Neurology
Alfredo Ramos-Miguel, Ken Sawada, Andrea A. Jones, Allen E. Thornton, Alasdair M. Barr, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer
ACTA NEUROPATHOLOGICA
(2017)
Review
Neurosciences
John Yin, Alasdair M. Barr, Alfredo Ramos-Miguel, Ric M. Procyshyn
CURRENT NEUROPHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Cathy K. Wang, Ana Aleksic, Michael S. Xu, Ric M. Procyshyn, Colin J. Ross, Fidel Vila-Rodriguez, Alfredo Ramos-Miguel, Ryan Yan, William G. Honer, Alasdair M. Barr
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2016)
Article
Neurosciences
Alfredo Ramos-Miguel, Jesus A. Garcia-Sevilla, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer, M. Julia Garcia-Fuster
MOLECULAR NEURODEGENERATION
(2017)
Article
Psychiatry
Clare L. Beasley, William G. Honer, Alfredo Ramos-Miguel, Fidel Vila-Rodriguez, Alasdair M. Barr
SCHIZOPHRENIA RESEARCH
(2020)
Article
Medicine, General & Internal
Charles C. White, Hyun-Sik Yang, Lei Yu, Lori B. Chibnik, Robert J. Dawe, Jingyun Yang, Hans-Ulrich Klein, Daniel Felsky, Alfredo Ramos-Miguel, Konstantinos Arfanakis, William G. Honer, Reisa A. Sperling, Julie A. Schneider, David A. Bennett, Philip L. De Jager
Article
Neurosciences
Alfredo Ramos-Miguel, Andrea A. Jones, Ken Sawada, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer
NEUROBIOLOGY OF DISEASE
(2018)
Article
Neurosciences
Alfredo Ramos-Miguel, Kristina Gicas, Jehan Alamri, Clare L. Beasley, Andrew J. Dwork, J. John Mann, Gorazd Rosoklija, Fang Cai, Weihong Song, Alasdair M. Barr, William G. Honer
Article
Neurosciences
Alfredo Ramos-Miguel, Vilte Barakauskas, Jehan Alamri, Masatoshi Miyauchi, Alasdair M. Barr, Clare L. Beasley, Gorazd Rosoklija, J. John Mann, Andrew J. Dwork, Annie Moradian, Gregg B. Morin, William G. Honer
Article
Clinical Neurology
Alfredo Ramos-Miguel, Andrea A. Jones, Vladislav A. Petyuk, Vilte E. Barakauskas, Alasdair M. Barr, Sue E. Leurgans, Philip L. De Jager, Kaitlin B. Casaletto, Julie A. Schneider, David A. Bennett, William G. Honer
Summary: The study identified key components within the presynaptic SNARE machinery that are associated with maintaining brain reserve and cognitive function. Select presynaptic proteins were found to play a significant role in cognitive performance, while altered levels of certain proteins could lead to synaptic dysfunction and cognitive impairment.
ACTA NEUROPATHOLOGICA
(2021)
Article
Pharmacology & Pharmacy
Alfredo Ramos-Miguel, Pilar Sanchez-Blazquez, Jesus A. Garcia-Sevilla
Summary: The study demonstrates that alpha(2A)-AR agonists (UK) utilize Gαi(2) and Gαz proteins to modulate the MEK-ERK pathway in mouse brain cortex, but not the FADD pathway, while CB1-R agonists (WIN) do not require Gαi(2) and Gαz proteins to mediate these pathway changes.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Fernando Yanez-Gomez, Alfredo Ramos-Miguel, Jesus A. Garcia-Sevilla, Jorge Manzanares, Teresa Femenia
Summary: The study explored the role of the opioidergic system in anxiety-related behaviors. PDYN knockout mice had lower levels of certain MAPKs and FADD in the cortex and thalamus compared to normal mice. Exposure to stress stimuli activated certain signaling pathways, but this activation was reduced in PDYN-deficient mice. These findings suggest that neuroplasticity in cortical-thalamic regions is altered in PDYN-KO mice, and the PDYN gene is required for certain pathway activations under stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
William G. Honer, Alfredo Ramos-Miguel, Jehan Alamri, Ken Sawada, Alasdair M. Barr, Julie A. Schneider, David A. Bennett
DIALOGUES IN CLINICAL NEUROSCIENCE
(2019)
Meeting Abstract
Psychiatry
Alfredo Ramos-Miguel, Alasdair Barr, Andrew Dwork, Gorazd Rosoklija, John Mann, William Honer
SCHIZOPHRENIA BULLETIN
(2017)