Article
Cell Biology
Hui Yang, Qiuyu Sun, Feifei Chong, Xiaoru Jiang, Yanli Wang, Kedi Xu, Yuanlin Zou, Linping Xu, Chunhua Song
Summary: The study revealed an association between MIR2052HG gene polymorphism and breast cancer susceptibility, particularly showing that the MIR2052HG rs34841297 A/- genotype may affect the proliferation, invasion, and migration of breast cancer cells by modulating interactions with miR-4456.
Article
Oncology
Yuxin Wang
Summary: The study revealed that LRRC3B gene polymorphisms were associated with the risk of breast cancer, suggesting that LRRC3B variants might be helpful in predicting breast cancer progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zheng Lv, Changgui Kou, Naifei Chen, Lin Jia, Xu Sun, Yangyang Gao, Rilan Bai, Ming Yang, Jiuwei Cui
Summary: This study indicates that HOTAIR SNPs (rs920778 and rs4759314) are significantly associated with BC susceptibility and prognosis in the northeastern Chinese population, highlighting their importance in the occurrence and development of BC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiuyu Sun, Feifei Chong, Xiaoru Jiang, Yanli Wang, Kedi Xu, Yuanlin Zou, Chunhua Song
Summary: This study investigated the genetic variation of the lncRNA CDKN2B-AS1 SNPs and its regulation on the invasion and metastasis of Breast cancer. The findings suggest that CDKN2B-AS1 gene polymorphism may be associated with the susceptibility of BC, and the rs10965215 A/G genotype of CDKN2B-AS1 may affect the proliferation, invasion, and migration of BC cells by modulating the interactions with miR-4440.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Oncology
Rui Peng, Jingjing Cao, Qiaoyun Guo, Qiuyu Sun, Linping Xu, Xiaojuan Xie, Chunhua Song
Summary: The study showed that the BCAR4 gene variant rs13334967 is associated with lower breast cancer risk, and individuals carrying the AT and TT genotypes have lower BCAR4 mRNA expression compared to those with the AA genotype. This suggests that BCAR4 may be a potential biomarker and therapeutic target for breast cancer.
Article
Biotechnology & Applied Microbiology
Jian Xiao, Chuming Zhu, Peidong Ni, Wangwang Chen, Zengliang Li, Hao Fan, Xiang Ma, Zekuan Xu, Li Yang
Summary: The study found that the polymorphism rs61396151 in the SNHG5 gene is associated with a decreased risk of gastric cancer, but not with clinicopathological features. However, it was associated with overall survival rate, which was reversed after adjustments.
Review
Pathology
Esmat Abdi, Saeid Latifi-Navid, Hamid Latifi-Navid
Summary: Breast cancer is the most prevalent cancer in females worldwide, with a complex interaction of variables like lifestyle, climate, genetics, and reproductive factors. Long non-coding RNAs (lncRNAs) play important roles in breast cancer development, with their polymorphisms predictive of cancer incidence and useful for early detection and customized therapy. Further large-scale trials and functional assessments are needed to validate the results and shed light on the etiology of breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Yuhe Wang, Mingyue Chen, Faling Yi, Jinpeng Xu, Changchun Liu, Ziyi Zhang, Ping Wang, Tianbo Jin, Mingwei Chen
Summary: This study aimed to evaluate the association of single nucleotide polymorphisms (SNPs) of the glutaminase (GLS) gene with lung cancer susceptibility in the Chinese Han population. The results showed that GLS rs143584207 and rs6713444 were significantly associated with lung cancer susceptibility. Further subgroup and clinical information analyses revealed that these SNPs could reduce lung cancer susceptibility in different subgroups and had a protective effect on non-smokers and patients with advanced lung cancer. The findings suggest that GLS SNPs could be potential markers for the timely treatment of lung cancer in the Chinese Han population.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Gaowen Liu, Ying Duan
Summary: In this study, it was found that CYP11B1 gene polymorphisms were closely associated with ischemic stroke in the Chinese Han population. Specifically, rs5283 was associated with an increased susceptibility to ischemic stroke, while rs6410 had a protective influence on the risk of ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Infectious Diseases
Zhiyuan Wu, Yufeng Liang, Yunlong Zuo, Yufen Xu, Hanran Mai, Lei Pi, Di Che, Xiaoqiong Gu
Summary: This study found that the CCAT2 gene polymorphism rs6983267 T > G may be associated with an increased risk of pediatric sepsis in southern China, especially in children under 60 months old, male, and with sepsis. Further multicenter studies are needed to confirm these findings.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Genetics & Heredity
Ziqi Jia, Yansong Huang, Jiaqi Liu, Gang Liu, Jiayi Li, Hengyi Xu, Yiwen Jiang, Song Zhang, Yidan Wang, Gang Chen, Guangdong Qiao, Yalun Li
Summary: Through a study on genetic polymorphisms, we found significant associations between breast cancer risk and SNPs rs12493607 (TGFBR2), rs4784227 (CASC16), and rs2046210 (ESR1) in the Chinese female population. Further analysis revealed associations between different subtypes of breast cancer and different SNPs. These findings provide important insights into breast cancer susceptibility and personalized treatment.
Article
Oncology
Yanan Feng, Zhenzhen Wang, Manning Zhu, Songxue Li, Shuang Dong, Liping Gong, Xiaoying Li, Shuang Zhang, Tianshuang Jia, Xianchao Kong, Jiawei Tian, Litao Sun
Summary: Cervical cancer is a major malignant tumor affecting women globally. This study explored the association between SNPs in four different genes and susceptibility to cervical cancer, finding that three SNPs were associated with clinical characteristics of cervical cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Baoping Hu, Yuhe Wang, Zhongtao Wang, Xue He, Li Wang, Dongya Yuan, Yongjun He, Tianbo Jin, Shumei He
Summary: By studying the northwest Chinese Han population, this research identified the relationships between polymorphisms in or near the SLC11A1 gene and age- and sex-specific tuberculosis risk.
FRONTIERS IN GENETICS
(2022)
Article
Medical Laboratory Technology
Min Jin, Fengke Lu, Xi Li, Wei Zhou, Sihui Li, Yanting Jiang, Huiling Wu, Jian Wang
Summary: This study found that the rs9266 gene polymorphism and TAT haplotype in the KRAS gene may be associated with an increased risk of breast cancer in Chinese women, while the GAC haplotype may be a protective factor against breast cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
