Article
Cell Biology
Guohui Peng, Jing Guan, Pengfei Leng, Lijun Peng, Manchao Cao, Yuanfa Feng
Summary: This study investigates the expression, biological functions, and molecular mechanisms of circ_0000515 in bladder cancer (BC). The results show that circ_0000515 promotes the viability, migration, and aggressiveness of BC cells by regulating the miR-542-3p/ILK axis.
Article
Medicine, Research & Experimental
Chen Yang, Zezhong Mou, Zheyu Zhang, Siqi Wu, Quan Zhou, Yiling Chen, Jian Gong, Chenyang Xu, Yuxi Ou, Xinan Chen, Xiyu Dai, Haowen Jiang
Summary: Our study revealed the tumor suppressive role of circRBPMS in bladder cancer by targeting the miR-330-3p/RAI2 axis, leading to inhibition of cell proliferation and metastasis. Downregulation of circRBPMS is associated with aggressive bladder cancer, while upregulation can suppress cell proliferation and migration.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Xinlan Qu, Yuan Fang, Siying Zhuang, Yuanzhen Zhang
Summary: The study demonstrates that miR-542-3p can affect the differentiation of HESCs by down-regulating ILK, inhibiting angiogenesis, reducing tumor growth and invasion, and inducing apoptosis.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang
Summary: The upregulated expression of hsa_circRNA_0088036 in bladder cancer is positively correlated with overall survival and clinicopathologic characteristics. Knockdown of hsa_circRNA_0088036 inhibits the growth, migration, and invasion of bladder cancer cells, acting through the miR-140-3p/FOXQ1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Heping Zhang, Jingfang Wang, Taoyuan Yu, Jingmin Wang, Jun Lu, Zongyang Yu
Summary: This study demonstrates that silencing long non-coding RNA cancer susceptibility candidate 9 can significantly inhibit the proliferation and invasion of CRC cells. miR-542-3p and integrin-linked kinase play a negative regulatory role in this process.
Article
Medicine, Research & Experimental
Liang Chen, Wencheng Li, Zhiqin Li, Yarong Song, Jun Zhao, Zhaohui Chen, Gallina Kazobinka, Lulu Li, Yifei Xing, Teng Hou
Summary: The study identified circNUDT21 as an oncogenic circular RNA that promotes bladder cancer progression through the miR-16-1-3p/MDM2/p53 axis. This suggests circNUDT21 as a potential therapeutic target for bladder cancer. CircNUDT21 regulates the proliferative and invasive abilities of bladder cancer cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Senjie Du, Hongying Li, Fen Lu, Shang Zhang, Jian Tang
Summary: This study demonstrated that circ-ZNF609 is significantly upregulated in glioma and promotes tumor growth and metastasis by enhancing PLK1 expression through competitively binding miR-1224-3p. Inhibition of circ-ZNF609 could suppress glioma cell proliferation, migration and invasion, suggesting circ-ZNF609 as a potential therapeutic target for glioma.
Article
Oncology
Qiang Tu, Xiaoxiang You, Jun He, Xuguang Hu, Changji Xie, Guohui Xu
Summary: The study revealed that circ-0003006 was upregulated in HCC tissues and promoted HCC progression by sponging miR-542-3p to release inhibition on HIF-1A, potentially acting as a sponge to regulate gene expression.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiaoning Luo, Jiewen Liu, Xiangcai Wang, Jun Yuan, Yu Zhang
Summary: In cervical cancer, circ-DTL and DCUN1D1 were upregulated, while miR-758-3p was downregulated. Inhibition of circ-DTL suppressed the proliferation, migration, and invasion of cervical cancer cells, and induced cell cycle arrest and apoptosis. Circ-DTL interacted with miR-758-3p to regulate the progression of cervical cancer. Additionally, miR-758-3p suppressed cervical cancer malignancy by inhibiting DCUN1D1 expression. Circ-DTL acts as a tumor promoter in cervical cancer development through the miR-758-3p/DCUN1D1 pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Oncology
Pingxin Zhang, Hang Gao, Ruping Yan, Lu Yu, Chengxing Xia, Delin Yang
Summary: This study investigates the effect of hsa_circ_0070512 on the function and mechanism of prostate cancer (PCa). Hsa_circ_0070512 was found to be increased in PCa tissues and cells, predominantly located in the cytoplasm of PCa cells. Overexpression of hsa_circ_0070512 significantly increased PCa cell proliferation and migration, while silencing it decreased these processes. Mechanistically, hsa_circ_0070512 acts as a sponge for miR-338-3p, and its regulation of the hedgehog signaling pathways through miR-338-3p enhances PCa growth and migration.
Article
Cell Biology
Gang Ma, Guichen Li, Wufeng Fan, Yuanhong Xu, Shaowei Song, Kejian Guo, Zhe Liu
Summary: The study reveals that circ-0005105 is upregulated in PDAC tissues and cells, promoting cellular proliferation and invasion. By modulating the miR-20a-3p-COL11A1 axis, circ-0005105 activates epithelial-mesenchymal transition and is associated with malignant clinical phenotype and poor prognosis in PDAC patients.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Liang Liu, Wenze Huang
Summary: This study investigates the role of circ_0020378, miR-339-3p, and COL1A1 in osteosarcoma progression. The upregulation of circ_0020378 and COL1A1, along with the downregulation of miR-339-3p, is observed in osteosarcoma cells and tissues. Silencing circ_0020378 inhibits the proliferation, colony formation, and migration of osteosarcoma cells. Circ_0020378 acts as a sponge for miR-339-3p, which targets COL1A1. Therefore, circ_0020378 promotes osteosarcoma progression by downregulating miR-339-3p/COL1A1 expression.
CANCER BIOLOGY & THERAPY
(2023)
Article
Oncology
Yali Yu, Guixiang Dong, Zijun Li, Yan Zheng, Zhisong Shi, Guanghui Wang
Summary: This study discovered that circ-LRP6 inhibits the proliferation, migration, and invasion of osteosarcoma cells by regulating the miR-141-3p/HDAC4/HMGB1 axis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Hui Long, Qin Li, Zhenping Xiao, Bo Yang
Summary: The study revealed that MIR22HG was significantly overexpressed in osteoarthritis, and it played a role in regulating chondrocyte proliferation, apoptosis, and extracellular matrix degradation through the miR-9-3p/ADAMTS5 pathway.
Article
Oncology
Yu Huang, Wenhao Ge, Yuan Ding, Lufei Zhang, Jiarong Zhou, Yang Kong, Bijun Cui, Bingqiang Gao, Xiaohui Qian, Weilin Wang
Summary: The study revealed that circSLC7A11 was significantly overexpressed in hepatocellular carcinoma (HCC) tissues and cells, and high circSLC7A11 expression was associated with poor prognosis in HCC patients. Experimental results demonstrated that circSLC7A11 accelerated HCC progression and metastasis through the circSLC7A11/miR-330-3p/CDK1 axis.
CANCER CELL INTERNATIONAL
(2021)
