Article
Cell Biology
Kun Gao, Yanan Zhu, Hui Wang, Xianwei Gong, Zhiyong Yue, Aiai Lv, Xuanchen Zhou
Summary: The active chemical components of Baiying Qinghou decoction were predicted to be sitosterol and quercetin, which showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway. These proteins may be the candidate targets for the treatment of laryngeal squamous cell carcinoma.
Article
Oncology
Lejun Zhang, Zhaoting Ling, Zhengqiang Hu, Guanmin Meng, Xinqiang Zhu, Huifang Tang
Summary: Through network pharmacology analysis, this study found that Huanglianjiedu Decoction may potentially play a therapeutic role in oral squamous cell carcinoma by inhibiting p-ERK1/2 and p-NF-kappa B p65(S468).
CANCER CELL INTERNATIONAL
(2021)
Article
Integrative & Complementary Medicine
Jiye Chen, Yongjian Zhang, Yongcheng Wang, Ping Jiang, Guofeng Zhou, Zhaoyu Li, Jinlong Yang, Xiao Li
Summary: This study revealed that the potential mechanisms and therapeutic effects of Guizhi decoction on hypertension may be attributed to the regulation of cardiac inflammation and fibrosis.
Article
Cell Biology
Yu-peng Chen, Ke-xin Wang, Jie-qi Cai, Yi Li, Hai-lang Yu, Qi Wu, Wei Meng, Han-duo Wang, Chuan-hui Yin, Jie Wu, Mian-bo Huang, Rong Li, Dao-gang Guan
Summary: This study constructs a functional response space by combining the pathogenetic genes of stroke and the targets of Xiao-Xu-Ming decoction (XXMD), and selects key functional components group (KFCG) using a novel node importance calculation method and dynamic programming strategy. The results improve the understanding of the action mechanism of XXMD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Menghan Wang, Ni Zheng, Zhongchao Mai, Borong Zhou, Xinlin Yang, Miao Zhang, Wei Xia, Ying Ye
Summary: This study investigated the specific mechanism of action of Fuzheng Xiegan decoction (FXD) in hepatocellular carcinoma (HCC) through in vitro experiments. The results demonstrated that FXD can inhibit cell proliferation, induce cell cycle arrest and apoptosis, and inhibit invasion and migration of HCC cells. Additionally, the study identified the active ingredients of FXD, potential targets, and its inhibitory effect on the PI3K/Akt and MAPK/ERK signaling pathways.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Integrative & Complementary Medicine
Zhiqiang Chen, Tong Lin, Xiaozhong Liao, Zeyun Li, Ruiting Lin, Xiangjun Qi, Guoming Chen, Lingling Sun, Lizhu Lin
Summary: According to network pharmacology strategy and experimental results, Yinchenhao decoction exerts anti-tumor effects through multiple components, targets, and pathways, providing novel ideas for the development of preparations and the treatment of cholangiocarcinoma.
Article
Medicine, General & Internal
Liu Yang, Senwang Zheng, Ajiao Hou, Song Wang, Jiaxu Zhang, Huan Yu, Xuejiao Wang, Wei Lan
Summary: In this study, network pharmacology and molecular docking technology were used to explore the molecular mechanisms of the Duhuo Jisheng decoction in the treatment of osteoarthritis. The results showed that the decoction can treat OA by regulating multiple signaling pathways and participating in various biological processes.
Review
Medicine, General & Internal
Yuan Liu, Di Luo, Bo Xu
Summary: This study used traditional Chinese medicine systems pharmacology and gene analysis to explore the pharmacological mechanism and targets of Danggui Niantong decoction (DGNTD) in treating gout. The results showed that the active compounds of DGNTD regulate cell metabolism and improve inflammatory response to treat gout. This provides insights for the development of new drugs for gout.
Article
Medicine, General & Internal
Qian Zhang, Jingtao Liang, Ying Zhou
Summary: This study discussed the relevant targets and mechanisms of GZD in treating MPS from the perspective of network pharmacological analysis, reflecting the characteristics of multi-component, multi-target, and multiple pathways, providing a theoretical basis for clinical application.
Article
Cell Biology
Xianhai Li, Hua Tang, Qiang Tang, Wei Chen
Summary: Using network pharmacology, it was found that Huang-Lian-Jie-Du decoction treats pneumonia mainly by regulating the host immune inflammatory response, oxidative stress reaction, and antibacterial microorganisms. The therapeutic effect is greater on bacterial pneumonia compared to viral pneumonia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shakeel Ahmad Khan, Terence Kin Wah Lee
Summary: This study investigated the active phytochemicals and molecular mechanisms of Cnidium monnieri in treating HCC. Results showed that Cnidium monnieri may exert its anti-HCC effects by affecting multiple gene targets and main signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jinxia Yuan, Fei Yan, Wei Li, Guoliang Yuan
Summary: In this study, the effect of Xuefu Zhuyu Decoction on atherosclerosis was evaluated using a network pharmacological approach. The results showed that Xuefu Zhuyu Decoction has multiple components and targets, indicating its potential in treating atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Yicheng Guo, Huiqun Gan, Shigui Xu, Guosheng Zeng, Lili Xiao, Zhijun Ding, Jie Zhu, Xinglong Xiong, Zhiyuan Fu
Summary: This study aims to confirm the therapeutic efficacy of Xijiao Dihuang decoction (XJDHT) in treating psoriasis and explore its potential mechanisms. The study used mouse models and database analysis to identify the therapeutic effects of XJDHT on psoriasis and screened 8 key genes. Further experiments confirmed that XJDHT down-regulated the expression of VEGFA, MMP9, STAT3, TNF, and IL-17A, thereby improving psoriatic lesions.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Qi Dong, Yu-Jiao Huang, Zhi-Yu Tao, Han-Yue Huang, Lin-Hui Luo, Ying-Qing Zhang
Summary: This study explores the mechanism of Lingguizhugan Decoction in treating hypertension through network pharmacology and molecular simulation. By screening active ingredients and targets, and analyzing their roles in signaling pathways, it is found that Lingguizhugan Decoction treats hypertension through a multi-component, multi-target, and multi-pathway approach.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Medicine, General & Internal
Mingmin Tian, Anming Yang, Qinwei Lu, Xin Zhang, Guangjie Liu, Gaofeng Liu
Summary: Menopausal syndrome (MS) is a series of symptoms caused by autonomic nervous system dysfunction due to decreased sex hormones before and after menopause. Baihe Dihuang (BHDH) decoction has a positive effect on MS, but the mechanism is still unclear. This study aimed to reveal the underlying mechanism through network pharmacology. The results showed that BHDH decoction has multiple active ingredients and targets that are effective for MS, and it acts on critical targets such as tumor protein P53, Serine/threonine-protein kinase AKT, epidermal growth factor receptor, Estrogen Receptor 1, and jun proto-oncogene. Additionally, the study identified specific pathways and molecular interactions involved in the therapeutic effect of BHDH decoction on MS.
