Journal
ADVANCED MATERIALS
Volume 34, Issue 13, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202109920
Keywords
cancer therapy; DNA nanotechnology; persistent luminescence nanoparticles; photodynamic therapy
Categories
Funding
- National Natural Science Foundation of China [21621004, 31971305, 81771880, 81871393]
- Ministry of Science and Technology of China (National Key Technology Research and Development Program) [2018YFA0902300]
- Tianjin Natural Science Foundation (Basic research plan) [18JCJQJC47600, 19JCQNJC12800]
- Ningbo Natural Science Foundation [2021J009]
Ask authors/readers for more resources
A DNA nanocomplex is developed for photodynamic therapy (PDT) in breast cancer, enabling tumor-site glutathione-activated therapy without the need for external laser excitation. The nanocomplex integrates persistent-luminescence nanoparticles (PLNPs) as a self-illuminant to activate a photosensitizer and inhibit tumor growth through the production of cytotoxic oxygen.
Photodynamic therapy (PDT) is a therapeutic strategy that is dependent on external light irradiation that faces a major challenge in cancer treatment due to the poor tissue-penetration depths of light irradiation. Herein, a DNA nanocomplex that integrates persistent-luminescence nanoparticles (PLNPs) is developed, which realizes tumor-site glutathione-activated PDT for breast cancer without exogenous laser excitation. The scaffold of the nanocomplex is AS1411-aptamer-encoded ultralong single-stranded DNA chain with two functions: i) providing sufficient intercalation sites for the photosensitizer, and ii) recognizing nucleolin that specifically overexpresses on the surface of cancer cells. The PLNPs in the nanocomplex are energy-charged to act as a self-illuminant and coated with a shell of MnO2 for blocking energy degradation. In response to the overexpressed glutathione in cancer cells, the MnO2 shell decomposes to provide Mn2+ to catalytically produce O-2, which is essential to PDT. Meanwhile, PLNPs are released and act as a self-illuminant to activate the photosensitizer to convert O-2 into cytotoxic O-1(2). Significant tumor inhibition effects are demonstrated in breast tumor xenograft models without exogenous laser excitation. It is envisioned that a laser-excitation-free PDT strategy enabled by the PLNP-DNA nanocomplex promotes the development of PDT and provides a new local therapeutic approach.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available