Amino-Acid-Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy

Photothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design of photothermal nanomedicine remains extremely challenging due to the vulnerability and variability of noncovalent interactions governing supramolecular self-assembly. Herein, it is reported that amino acid encoding is a facile and potent means to design and construct supramolecular photothermal nanodrugs with controlled therapeutic activities. It is found that the amount and type of amino acid dominates the assembled nanostructures, structural stability, energy-conversion pathway, and therapeutic mechanism of the resulting nanodrugs. Two optimized nanodrugs are endowed with robust structural integrity against disassembly along with high photothermal conversion efficiency, efficient cellular internalization, and enhanced tumor accumulation, which result in more efficient tumor ablation. This work demonstrates that design based on amino acid encoding offers an unprecedented opportunity for the construction of remarkable photoactive nanomedicines toward cancer diagnostics and therapeutics.

Automated summary

Photothermal nanomedicine based on the self-assembly of biological components offers a promising approach for precision cancer therapy. This study demonstrates that amino acid encoding can be used to design and construct supramolecular photothermal nanodrugs with controlled therapeutic activities. By optimizing the amount and type of amino acids, the resulting nanodrugs exhibit robust structural integrity, high photothermal conversion efficiency, efficient cellular internalization, and enhanced tumor accumulation, leading to more effective tumor ablation.