Article
Medicine, General & Internal
Charles L. Bennett, Shamia Hoque, Nancy Olivieri, Matthew A. Taylor, David Aboulafia, Courtney Lubaczewski, Andrew C. Bennett, Jay Vemula, Benjamin Schooley, Bartlett J. Witherspoon, Ashley C. Godwin, Paul S. Ray, Paul R. Yarnold, Henry C. Ausdenmoore, Marc Fishman, Georgne Herring, Anne Ventrone, Juan Aldaco, William J. Hrushesky, John Restaino, Henrik S. Thomsen, Robert Marx, Cesar Migliorati, Salvatore Ruggiero, Chadi Nabhan, Kenneth R. Carson, June M. McKoy, Y. Tony Yang, Martin W. Schoen, Kevin Knopf, Linda Martin, Oliver Sartor, Steven Rosen, William K. Smith
Summary: This study examined very serious ADRs associated with 15 drugs and one device reported between 1997 and 2019, leading to 753,900 injured persons. It found that 11 out of 18 clinicians reported harms, including verbal threats and loss of positions. Sales decreased significantly post-FDA Advisory Committee meetings, and manufacturers faced criminal fines for failing to inform about ADRs.
Review
Chemistry, Medicinal
Diane Merino, Arnaud Fernandez, Alexandre O. Gerard, Nouha Ben Othman, Fanny Rocher, Florence Askenazy, Celine Verstuyft, Milou-Daniel Drici, Susanne Thummler
Summary: Children and youth treated with antipsychotic drugs may experience adverse drug reactions and poor treatment response, which could be related to genetic variations in drug metabolism. The most frequent adverse reactions observed were weight gain and metabolic syndrome, followed by lack of therapeutic effect and neurological issues. Studies on the pharmacogenetic profiles associated with these drugs have yielded conflicting results, but some cases have shown significant clinical improvement through genotyping. Further research, especially on the key enzyme CYP1A2, is needed to improve the risk-benefit assessment of prescribing olanzapine, clozapine, and/or loxapine for children and youth.
Article
Medicine, General & Internal
Yan-zhong Han, Yu-ming Guo, Peng Xiong, Fei-lin Ge, Jing Jing, Ming Niu, Xu Zhao, Zhao-fang Bai, Hai-bo Song, Xiao-he Xiao, Jia-bo Wang
Summary: This study found that the aging population is more susceptible to liver-related ADRs, with the relative risk increasing exponentially with age. It is important to address risk management for older adults when using drugs with a high correlation to the risk of ADRs.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yanping Li, Yue Ming, Ruoqiu Fu, Chen Li, Yuanlin Wu, Tingting Jiang, Ziwei Li, Rui Ni, Li Li, Hui Su, Yao Liu
Summary: Chimeric antigen receptor (CAR)-T cell therapy is an effective treatment for refractory/relapsed hematological malignancies. However, it also causes adverse effects, with cytokine release syndrome (CRS) being the most common reaction. Severe CRS can lead to other toxicities, limiting the widespread application of CAR-T therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Robert J. Unwin
Summary: Toxic nephropathy, a growing concern, is often caused by new drugs and polypharmacy. Patients' lack of knowledge about their medications and the prevalence of unapproved drugs contribute to the problem. Early detection, drug withdrawal, and supportive care are crucial for effective treatment.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Neurosciences
Madeleine S. A. Tan, Faraz Honarparvar, James R. Falconer, Harendra S. Parekh, Preeti Pandey, Dan J. Siskind
Summary: Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, with associations to reduced hospitalization and overall mortality. Studies show significant correlations between clozapine and norclozapine serum levels with triglycerides, heart rate, total cholesterol, and weight gain, indicating a need for further research on the cause-effect relationship between these levels and adverse drug reactions.
PSYCHOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yuting Shan, Lee Cheung, Yuqi Zhou, Yingbo Huang, R. Stephanie Huang
Summary: This review summarizes the current knowledge on sex differences in adverse drug reactions (ADRs) of commonly used psychotropic, cardiovascular, and analgesic medications. The main findings suggest that more than half of the evaluated ADRs show a sex difference in occurrence rate, with some medications causing more adverse reactions in women and others in men.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Eleanor G. Dixon, Shaista Rasool, Brian Otaalo, Ashmika Motee, James W. Dear, Derek Sloan, Helen R. Stagg
Summary: Missed doses of anti-TB treatment are often caused by adverse drug reactions (ADRs), but the relative contribution of ADRs to missed doses and the patterns of missed doses due to ADRs have not been well-studied. This scoping review aims to address these knowledge gaps.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Pansakon Wattanachai, Warayuwadee Amornpinyo, Parinya Konyoung, Danklai Purimart, Usanee Khunarkornsiri, Oranuch Pattanacheewapull, Wichittra Tassaneeyakul, Nontaya Nakkam
Summary: This study extensively characterizes the associations between HLA genetic polymorphisms and several phenotypes of beta-lactam antibiotics-related severe cutaneous adverse reactions (SCARs).
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Thomas A. Baillie
Summary: Covalent inhibition of target proteins using ligands with weakly electrophilic warheads is increasingly being adopted as a design strategy for novel therapeutics, with several covalent drugs now approved for oncology indications. Design principles, unique benefits, and risks associated with reversible and irreversible binders are discussed, along with considerations to de-risk covalent inhibitors for off-target effects. Safe use of covalent drugs relies on high selectivity for the intended protein target, as well as optimization of pharmacokinetics to reduce daily doses and minimize potential toxicity.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Article
Medicine, Research & Experimental
Daria Schetz, Tara Elizabeth Scott, Wojciech Waldman, Jacek Sein Anand, Marek Wiergowski, Ivan Kocic
Summary: This study compares the incidence of adverse drug reactions (ADR) of antidepressive agents, benzodiazepines, and antipsychotics plus mood stabilizers (AaMS) in Poland and Australia during the COVID-19 pandemic and before. The results show a significant increase in ADR reports in Poland, with the highest increase seen in antidepressive agents. In Australia, there is a modest increase in ADR reports for antidepressive agents and a significant increase for benzodiazepines.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Caitriona Cahir, Carmel Curran, Caroline Walsh, Anne Hickey, Ross Brannigan, Ciara Kirke, David J. Williams, Kathleen Bennett
Summary: The study aimed to determine the prevalence and characteristics of ADR-related hospital admissions among older patients in Ireland and identify associated risk factors. The results showed that 10% of hospital admissions were ADR-related, with approximately 70% being potentially avoidable.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Fei-lin Ge, Ming Niu, Zi-xin Han, Jun-ling Cao, Jia-bo Wang, Zhao-fang Bai, Hai-bo Song, Yu-ming Guo, Xiao-he Xiao
Summary: The cases of hepatobiliary adverse drug reactions (ADR) related to BGZP showed an increasing trend year by year, partly due to irrational drug use. BGZP was mainly used for diseases caused by abnormal immune activation, and caution is recommended especially for female patients with immunological diseases.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Review
Medicine, General & Internal
Sarah Noetzlin, Gautier Breville, Joerg D. Seebach, Giacomo Gastaldi
Summary: This review discusses the wide range of potential side effects of short-term systemic glucocorticoid administration, particularly focusing on metabolic conditions and management of hyperglycemia.
SWISS MEDICAL WEEKLY
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Duda-Chodak, Tomasz Tarko
Summary: Polyphenols are important components of plant-derived food that have a wide range of beneficial effects on human health. However, they can also have harmful effects, such as blocking iron uptake, inhibiting digestive enzymes, disrupting intestinal microbiota, interacting with drugs, and affecting hormonal balance. Public awareness needs to be raised on the potential side effects of polyphenol supplementation, especially for vulnerable populations.