Article
Immunology
Margaret M. Cortese, Allan W. Taylor, Lara J. Akinbami, Andrea Thames-Allen, Anna R. Yousaf, Angela P. Campbell, Susan A. Maloney, Theresa A. Harrington, E. Gloria Anyalechi, Datta Munshi, Satoshi Kamidani, C. Robinette Curtis, David W. McCormick, Mary A. Staat, Kathryn M. Edwards, C. Buddy Creech, Oidda Museru, Paige Marquez, Deborah Thompson, John R. Su, Elizabeth P. Schlaudecker, Karen R. Broder
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a rare complication of COVID-19 vaccination in children aged 5-11 years. Passive surveillance identified 58 children with laboratory evidence of past or recent SARS-CoV-2 infection and MIS-C, as well as 4 children without evidence. The occurrence of MIS-C without SARS-CoV-2 infection was very rare (<1 per million vaccinated children) during a period of extensive virus circulation.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Manfred S. Green, Victoria Peer, Avi Magid, Neta Hagani, Emilia Anis, Dorit Nitzan
Summary: The adverse events following COVID-19 mRNA vaccination are higher after the second dose and consistently higher in females at all ages, including local events such as pain at the injection site, systemic events such as fever, and sensory events such as paresthesia. It is important to assess and report vaccine adverse events by gender and take gender differences into account when determining dosing schedules.
Article
Immunology
Innocenza Palaia, Giuseppe Caruso, Violante Di Donato, Annarita Vestri, Anna Napoli, Giorgia Perniola, Matteo Casinelli, Danilo Alunni Fegatelli, Roberta Campagna, Federica Tomao, Debora D'Aniello, Guido Antonelli, Ludovico Muzii
Summary: The Pfizer-BioNTech COVID-19 vaccine was found to be safe and immunogenic in gynecologic oncology patients under chemotherapy. Serological monitoring and additional vaccine shots should be considered to enhance protection, as these patients had lower antibody titers compared to healthy women.
Article
Immunology
Immacolata Polvere, Serena Voccola, Alfredina Parrella, Gaetano Cardinale, Lucrezia Zerillo, Romualdo Varricchio, Jessica Raffaella Madera, Romania Stilo, Pasquale Vito, Tiziana Zotti
Summary: The Pfizer/BioNTech COVID-19 mRNA vaccine induces excellent antibody response against the spike protein of SARS-CoV-2, with individual differences in antibody response and the importance of monitoring antibody protection in the population for effective pandemic control.
Article
Urology & Nephrology
Seiji Kobayashi, Kazunori Fugo, Kazuto Yamazaki, Hiroyuki Terawaki
Summary: This case report describes the onset of minimal change disease (MCD) in a patient after receiving the second dose of the Pfizer-BioNTech mRNA vaccine for COVID-19. The patient achieved complete remission after treatment. While the definite causality between the vaccine and MCD is unclear, awareness of potential adverse effects of mRNA vaccines is crucial for determining their true incidence and frequency.
CLINICAL KIDNEY JOURNAL
(2021)
Editorial Material
Chemistry, Medicinal
Lavinia M. Lewis, Advait Badkar, David Cirelli, Rodney Combs, Thomas F. Lerch
Summary: The Pfizer and BioNTech teams collaborated to develop a safe and effective mRNA COVID-19 vaccine in a record time, thanks to global collaboration and parallel efforts. Their success was based on foundational science, clinical trials, continuous improvement, and large-scale manufacturing and delivery.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Virology
Christophe Abi Zeid Daou, Mohammad A. Natout, Nadine El Hadi
Summary: Vaccination has become a major solution in the global pandemic of COVID-19, but it is important to remain vigilant for potential side effects and life-threatening complications. Anaphylactic cases post vaccination may have a recurrence of symptoms, highlighting the need for awareness. Recognizing the potential risk of anaphylaxis in select individuals and having appropriate measures in place to deal with adverse events is crucial.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Jason Cham, Amitabh C. Pandey, Jacob New, Tridu Huynh, Lee Hong, Natalia Orendain, Eric J. Topol, Laura J. Nicholson
Summary: This study analyzed the kinetics of antibody response to different SARS-CoV-2 epitopes in healthcare workers who received the BNT162b2 vaccine. The results showed that most participants developed IgG antibodies to Spike SARS-CoV-2 after 2 weeks of vaccination, which continued to increase at week 4 but significantly decreased starting at 3 months and up to 6 months. In contrast, IgM response to the respective epitopes was minimal after vaccination.
Article
Immunology
Sami Abu-Halaweh, Rami Alqassieh, Aiman Suleiman, Mohammed Qussay Al-Sabbagh, Maram AbuHalaweh, Duaa AlKhader, Rozan Abu-Nejem, Roa'a Nabulsi, Mohammad Al-Tamimi, Mallak Alwreikat, Mazen Alnouti, Bayan Suleiman, Moh'd Yousef, Mohammad El Jarbeh, Abdel-Ellah Al-Shudifat, Ahmad Alqassieh, Isam Bsisu
Summary: This study compared early side effects of Sinopharm and Pfizer-BioNTech COVID-19 vaccines. Participants who received Pfizer-BioNTech vaccine had significantly higher frequencies of adverse reactions after the first dose, while those who received Sinopharm vaccine experienced a longer duration of side effects after the second dose. Overall, early adverse effects are more likely to occur with new-generation vaccines and are generally mild and treatable.
Article
Immunology
Roberto Scendoni, Cristina Petrelli, Mauro Giustozzi, Francesco O. Logullo
Summary: This paper presents a case of severe thrombotic complications in a 75-year-old woman after receiving the Pfizer-BioNTech COVID-19 vaccine. Laboratory tests showed no thrombophilic risk factors or thrombocytopenia in the patient. Although COVID-19 vaccines are crucial in controlling the pandemic, pharmacovigilance is still important for detecting potential multisystem thrombotic events.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Asher Shafrir, Johnny Amer, David Hakimian, Yael Milgrom, Muhammad Massarwa, Wadi Hazou, Ashraf Imam, Abed Khalaileh, Rifaat Safadi
Summary: This study assessed the impact of hepatic fibrosis on the efficacy of the BioNTech vaccine and found that immune suppression, older age, male gender, and advanced chronic liver disease are risk factors for lower vaccine response. The FIB-4 score can be used as a simple tool to prioritize candidates for a third-dose vaccine booster.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Immunology
Ariel Israel, Eugene Merzon, Yotam Shenhar, Ilan Green, Avivit Golan-Cohen, Alejandro A. Schaffer, Eytan Ruppin, Shlomo Vinker, Eli Magen
Summary: A population-based study in Israel found that individuals with chronic kidney disease and anemia had higher rates of COVID-19 infection within 14 days after booster vaccination.
Article
Infectious Diseases
Eric Tano, Stephanie San Martin, Stephen Girgis, Yadira Martinez-Fernandez, Carolina Sanchez Vegas
Summary: Pericarditis occurred in adolescents within 4 days of receiving the BNT162b2 vaccine. Further research is needed to understand the impact of the vaccine on adolescent heart health.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Immunology
Limor Friedensohn, Meital Zur, Maxim Timofeyev, Saar Burshtein, Yossi Ben Michael, Noam Fink, Elon Glassberg
Summary: The route of vaccine administration can impact the extent and quality of immune responses. A study showed that administering the Pfizer vaccine subcutaneously resulted in a seroconversion rate of 98.2% among military personnel, suggesting a potential alternative effective administration route.
Article
Biochemical Research Methods
Yuqi Zhou, Masako Nishikawa, Hiroshi Kanno, Ruoxi Yang, Yuma Ibayashi, Ting-Hui Xiao, Walker Peterson, Maik Herbig, Nao Nitta, Shigeki Miyata, Yogendra Kanthi, Gustavo K. Rohde, Kyoji Moriya, Yutaka Yatomi, Keisuke Goda
Summary: This study used image-based single-cell profiling and temporal monitoring to investigate the long-term effects of Pfizer-BioNTech COVID-19 vaccines on platelet function. The results showed that there were no significant or persisting platelet aggregation trends following the vaccine doses.
Article
Pediatrics
Ulrikka Nygaard, Laerke Vinge Larsen, Nadja Hawwa Vissing, Marie-Louise von Linstow, Charlotte Myrup, Anne Kiil Berthelsen, Anja Poulsen, Lise Borgwardt
Summary: This study investigated the application of (18)FDG-PET/CT in pediatric patients with non-diagnostic standard investigations, demonstrating its diagnostic value in some cases while highlighting challenges such as false positive and false negative results.
Editorial Material
Pediatrics
Ulrikka Nygaard, Nikolai Soren Kirkby, Kia Hee Schultz Dungu, Kim G. Nielsen, Tania Masmas, Klaus Juul, Peter Born, Soren Buus, Lone Graff Stensballe
Editorial Material
Pediatrics
Ulrikka Nygaard, Jens Nielsen, Jeppe Sylvest Angaard Nielsen, Astrid Thaarup Matthesen, Kia Hee Schultz Dungu, Ulla Birgitte Hartling, Mette Holm
Editorial Material
Pediatrics
Ulrikka Nygaard, Nikolai Soren Kirkby, Joakim Bloch, Naqash Javaid Sethi, Alex Christian Yde Nielsen, Anja Poulsen, Frederik Buchvald, Marie-Louise von Linstow, Nadja Hawwa Vissing
Letter
Pediatrics
Ulrikka Nygaard, Joakim Bloch, Kia Hee Schultz Dungu, Christine Vollmond, Frederik Fouirnaies Buchvald, Kim Gjerum Nielsen, Kim Kristensen, Anja Poulsen, Nadja Hawwa Vissing
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Immunology
Louise Bering, Anne Vinggaard Christensen, Nina Marie Birk, Lau Caspar Thygesen, Henning Bundgaard, Thomas Benfield, Ulrikka Nygaard, Jesper Johannesen, Susanne Dam Nielsen, Selina Kikkenborg Berg
Summary: This nationwide matched cohort study investigated the association between SARS-CoV-2 infection and new-onset type 1 diabetes (T1D) in children and adolescents. The study found that the risk of new-onset T1D in children and adolescents was not significantly increased after SARS-CoV-2 infection within 6 months.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
