Article
Chemistry, Multidisciplinary
Chunrong Yang, Yujie Li, Yuchen Yang, Qiankun Ni, Zeyu Zhang, Yi Chai, Jinghong Li
Summary: This study demonstrates the potential of enhancing the efficacy of immunotherapy for glioma by targeting and modulating the tumor microenvironment. The researchers designed a nanomedicine that silenced SOCS1 and triggered a strong antitumor immune response, inhibiting tumor growth.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Engineering, Biomedical
Xiaohui Wang, Hong Zhang, Xiaohui Chen, Chunrong Wu, Ke Ding, Guiyin Sun, Yang Luo, Debing Xiang
Summary: Various types of nanoparticles are utilized to achieve targeted delivery of anticancer drugs, improve efficacy, and reduce side effects. However, their therapeutic effects are not ideal due to tumor microenvironment abnormalities and nanoparticle properties. This review comprehensively discusses the factors hindering nanoparticle penetration into tumors and describes methods for improving nanoparticle distribution. Furthermore, it critically analyzes the future development of nanodrug delivery in oncology.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Environmental
Xiangqi Liu, Wei Feng, Huijing Xiang, Baihui Liu, Mujie Ye, Meng Wei, Rui Dong, Yu Chen, Kuiran Dong
Summary: Chemodynamic therapy using Fenton reactions to produce cytotoxic hydroxyl radicals has shown limited efficacy due to low endogenous H2O2 levels. This study developed a cascade catalytically reactive nanosystem using glucose oxidase to generate H2O2 for Fenton reactions, combined with photothermal therapy in the NIR-II window, resulting in enhanced anticancer effects in both epithelial and embryonal tumors.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Rebeca Burgos-Panadero, Souhaila H. El Moukhtari, Inmaculada Noguera, Carlos Rodriguez-Nogales, Susana Martin-Vano, Pablo Vicente-Munuera, Adela Canete, Samuel Navarro, Maria J. Blanco-Prieto, Rosa Noguera
Summary: Treatment of high-risk neuroblastoma is challenging due to metastases and drug resistance. This study found that the interaction between vitronectin and its ligands is related to the stiffness of the extracellular matrix in high-risk neuroblastoma, providing insights for targeting tumor cells within altered matrices using nanomedicine and combination therapy. Synergistic effects were observed between etoposide and cilengitide in increasing efficacy against neuroblastoma cells within these altered matrices.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Article
Chemistry, Multidisciplinary
Huimin Xu, Jianqiao Chang, Hao Wu, Haoyu Wang, Wenjing Xie, Yunchao Li, Xiaohong Li, Yang Zhang, Louzhen Fan
Summary: siRNA-based gene therapy is a promising strategy for tumor treatment. Novel gene vectors, such as LAAM GUA-CDs, which can target tumor cells and deliver siRNA without causing side effects, have been designed and synthesized. LAAM GUA-CDs loaded with siBcl-2 exhibit a high tumor inhibition rate, twice as effective as commercial Lipofectamine 2000. LAAM GUA-CDs provide a versatile approach for tumor-targeted siRNA delivery and cancer therapy.
Article
Chemistry, Multidisciplinary
Wenyue Zhang, Xiaodi Liu, Shuwen Cao, Qi Zhang, Xiaojiang Chen, Wanrong Luo, Jiabao Tan, Xiaolin Xu, Jing Tian, Phei Er Saw, Baoming Luo
Summary: By simultaneously altering the polarization of tumor-associated macrophages and regulating T cell function, a multifunctional nanoplatform was designed to maximize the efficacy of cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Yinan Zhong, Jianguang Zhang, Junmei Zhang, Yong Hou, Enping Chen, Dechun Huang, Wei Chen, Rainer Haag
Summary: This study established a new nanoenzyme system that can decrease extracellular matrix stiffness in the tumor microenvironment, enhancing the efficacy of chemotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Kai Zhang, Yuying Long, Zhaoyu Ma, Shuting Li, Yanli Zhao, Heyou Han
Summary: In this study, an engineered artificial nanoplatelet (MOAP) was developed to target thrombus at the residual tumor site and release drugs to inhibit immune checkpoint and reverse the tumor immunosuppressive microenvironment. The MOAP showed a good anti-tumor effect, inhibiting tumor recurrence and lung metastasis after surgery.
Article
Chemistry, Multidisciplinary
Mayumi Ikeda-Imafuku, Lily Li-Wen Wang, Danika Rodrigues, Suyog Shaha, Zongmin Zhao, Samir Mitragotri
Summary: This review examines the key advances in strategies to enhance the extravasation and retention effect of nanoparticles, as well as analyzes the clinical trials and translation of these strategies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Ju Huang, Xiaojing Leng, Tao Jiang, Lihong Xu, Jun Zheng, Mingxiao Fang, Jingxue Wang, Zhigang Wang, Liang Zhang
Summary: Immunotherapy has great potential for treating tumors, but antigen exposure and immuno-suppressive tumor microenvironment (TME) caused by hypoxia limit its effectiveness. This study developed an oxygen-carrying nanoplatform to reprogram the immunosuppressive TME and enhance photothermal-immunotherapy. The nanoplatform showed efficient oxygen release behavior and excellent hyperthermia performance, attenuating tumor hypoxia and exposing tumor-associated antigens. The combination of photothermal therapy with anti-PD-1 immunotherapy induced a strong antitumor immune response and suppressed tumor growth.
MATERIALS TODAY BIO
(2023)
Article
Medicine, Research & Experimental
Kamalpreet Kaur Sandha, Chittaranjan Behera, Pankaj Chibber, Rajesh Kumar, Amit Kumar, Dilip M. Mondhe, Gurdarshan Singh, Prem N. Gupta
Summary: The unique physiology of tumors limits the efficacy of chemotherapeutics. Nanomedicine has emerged as a new hope to improve the effectiveness of chemotherapy drugs. However, the transport barriers present within the tumor tissues limit the potential of nanomedicine. This study developed human serum albumin-based nanoparticles that showed significantly improved anticancer efficacy through the triple targeting approach (SPARC, EPR, TME modulation).
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Chunping Liu, Zhijin Fan, Dongyue He, Huiqi Chen, Shihui Zhang, Sien Guo, Bojun Zheng, Huan Cen, Yunxuan Zhao, Hongxing Liu, Lei Wang
Summary: Acute myocardial infarction is a major health problem worldwide and the repair of damaged myocardium remains a significant challenge. Inflammatory response triggered by myocardial injury leads to severe inflammatory signaling and heart failure. Currently, there is no effective approach to reverse the inflammatory microenvironment in injured myocardium, highlighting the urgent need for new therapeutic strategies.
Article
Chemistry, Multidisciplinary
Min Zhang, Dayan Yang, Caihong Dong, Hui Huang, Guiying Feng, Qiqing Chen, Yuanyi Zheng, Hailin Tang, Yu Chen, Xiangxiang Jing
Summary: This study reports the fabrication of two-dimensional (2D) nanosonosensitizers/nanocatalysts for in situ generation of nanosonosensitizers, which respond to the tumor microenvironment. The nanosonosensitizers showed enhanced sonodynamic therapy (SDT) efficacy due to in situ generation of TiO2 nanosonosensitizers and enhanced ROS production. The combination of SDT and chemodynamic therapy demonstrated synergistic therapeutic effects both in vitro and in vivo.
Review
Oncology
Lili Zhou, Manshu Zou, Yilin Xu, Peng Lin, Chang Lei, Xinhua Xia
Summary: Tumor immunotherapy is a powerful strategy for treating cancer by stimulating the immune system. However, the heterogeneity of tumors and immunosuppressive microenvironment make it difficult for immunotherapy to be effective. With the advancements in materials science and nanotechnology, innovative biomaterials and drug delivery systems can enhance the effectiveness of immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)