Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 4, Pages 5897-5907Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c14663
Keywords
micromotors; photosensitive microcarriers; cargo; enzymatic activity protection; accelerated substrate degradation
Funding
- University of Antioquia
- Max Planck Society [5661]
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Immobilizing enzymes in photosensitive Janus micromotors can protect their activity and accelerate substrate degradation through light-driven magnetic/catalytic motion, thus enhancing the efficiency of enzymatic processes.
Immobilizing enzymes into microcarriers is a strategy to improve their long-term stability and reusability, hindered by (UV) light irradiation. However, in such approaches, enzyme-substrate interaction is mediated by diffusion, often at slow kinetics. In contrast, enzyme-linked self-propelled motors can accelerate this interaction, frequently mediated by the convection mechanism. This work reports on a new photosensitive polymeric Janus micromotor (JM) for UV-light protection of enzymatic activity and efficient degradation of substrates accelerated by the JMs. The JMs were assembled with UV-photosensitive modified chitosan, co-encapsulating fluorescent-labeled proteins and enzymes as models and magnetite and platinum nanoparticles for magnetic and catalytic motion. The JMs absorbed UV light, protecting the enzymatic activity and accelerating the enzyme-substrate degradation by magnetic/catalytic motion. Immobilizing proteins in photosensitive JMs is a promising strategy to improve the enzyme's stability and hasten the kinetics of substrate degradation, thereby enhancing the enzymatic process's efficiency.
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