Article
Engineering, Biomedical
Kang Fang, Yanting Sun, Jingxian Yang, Xiaochun Hu, Mengyao Chen, Ruihao Li, Xinda Yang, Ting Fan, Junjie Wu, Xiaohan Tong, Chunyan Dong, Shuo Shi
Summary: An acid and glutathione (GSH) dual-controlled nanoplatform is designed to strengthen the antitumor efficacy and avoid toxicity to normal cells of cisplatin and triptolide through the synergy of 1+1 apoptosis and 1+1 ferroptosis. The nanosystem shows superior specificity and therapeutic outcomes while reducing the toxicity to normal cells/tissues.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Qingfa Tang, Yao Chen, Yusheng Zhang, Kewei Wang, Li Liu, Dongmei Pan, Qiang Liu, Cuiping Jiang
Summary: In this study, a ROS-responsive prodrug micelle (TS-IIA-PM) was fabricated for the co-delivery of TS-IIA and SAA, the main active constituents of traditional Chinese medicine Danshen, to achieve a synergistic anti-atherosclerotic effect.
MOLECULAR PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Guoqiang Rong, Maomao Xu, Suxin Shi, Quanjun Yao, Wei Cheng, Dekang Sang, Weixiong Yu, Yumei Qian, Lingling Shan
Summary: A new nanoplatform was successfully prepared by consolidating targeted DA-PTX and TA with the assistance of coordination between polyphenols and Fe3+, achieving low toxicity and synergistic therapy effect of PTX against tumors.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuxin Yang, Haijun Ning, Tianping Xia, Jianjun Du, Wen Sun, Jiangli Fan, Xiaojun Peng
Summary: An amphiphilic siRNA-photosensitizer conjugate (siPLK1-NB) that can self-assemble into nanoparticles has been developed for efficient siRNA delivery and lysosomal escape. These nanoparticles exhibit rapid cell endocytosis and outstanding tumor-targeting property. The reactive oxygen species generated after photoactivation can disrupt the lysosome membrane structure and facilitate siRNA escape, leading to effective inhibition of tumor cell growth.
ADVANCED MATERIALS
(2023)
Article
Medicine, Research & Experimental
Shouhui Yi, Rongqiang Liao, Wei Zhao, Yusheng Huang, Yi He
Summary: Combination therapy offers advantages for cancer treatment, but different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo, leading to uncontrollable concentration ratio of therapeutic agents. Multifunctional co-delivery systems can provide targeted delivery and controlled release in response to tumor microenvironment, resulting in better synergistic anticancer effect and potential clinical applications.
Article
Engineering, Environmental
Haitao Hu, Wenbin Dai, Yuhuang Zhang, Yue Huang, Jun Qian, Qiao Jin, Jian Ji, Zhe Tang
Summary: In this study, glutathione-activatable photosensitizer-conjugated nanoassemblies were fabricated using dual supramolecular self-assembly. The nanoassemblies showed unique properties in acidic tumor microenvironment, including charge conversion and enhanced cellular internalization. The research provides an innovative approach to fabricate drug nanocarriers.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Xinzhu Shan, Zhiqiang Zhao, Chen Wang, Jin Sun, Zhonggui He, Cong Luo, Shenwu Zhang
Summary: This review discusses the application of prodrug-engineered nanomedicines in synergistic chemo-phototherapy. They offer advantages of synergistic treatment effect and dosage reduction, but also face challenges in design rationale.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Xiaobei Huang, Tunan Chen, Ning Mu, Hou Wang Lam, Chen Sun, Ludan Yue, Qian Cheng, Cheng Gao, Zhen Yuan, Ruibing Wang
Summary: A novel supramolecular micelles-based approach was designed to co-deliver photosensitizer and hypoxia-responsive prodrug, aiming to enhance overall therapeutic efficacy by improving hypoxic conditions in solid tumor microenvironment, a major barrier for successful PDT treatment.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Xin Liu, Chi Meng, Guiqing Ji, Ji Liu, Peng Zhu, Jianqiang Qian, Shun-Xing Zhu, Yanan Zhang, Yong Ling
Summary: This study demonstrates the development of intelligent tumor microenvironment-responsive supramolecular nanosystems for precision cancer diagnosis and synergistic therapy, with capabilities of selective fluorescence imaging, logical computing, and remarkable treatment effects.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Jianhua Xiong, Xiaoyu Wang, Jaewon Kim, Jiankang Gong, Zhiqiang Mao, Jong Seung Kim, Zhihong Liu
Summary: A ROS-triggered self-immolative therapeutic prodrug, through the combination of photodynamic therapy and chemical therapy, can kill most non-CSCs tumor cells and block the growth of CSCs, thus increasing the therapeutic index.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Can Wu, Qishu Jiao, Chunlu Wang, Yaxin Zheng, Xiaohui Pan, Wenying Zhong, Keming Xu
Summary: This study designs and synthesizes a self-assembling peptide molecule (LND-K) that targets both integrin receptors and mitochondria of cancer cells, leading to enhanced ablation of mitochondrial function in melanoma cells. By co-assembling LND-K with an anionic photosensitizer TPPS4, a nanofibrillar hydrogel system is developed for slow release and prolonged retention of TPPS4, achieving synergistic killing of cancer cells in vitro and in vivo.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yuxun Ding, Xiaowen Hu, Yinzi Piao, Rong Huang, Lingping Xie, Xiaojian Yan, Hui Sun, Yuanfeng Li, Linqi Shi, Yong Liu
Summary: Prodrug nanoassemblies combine the advantages of prodrug and nanomedicines, offering targeted drug delivery and specific on-demand drug release. Lipid prodrug nanoassemblies prepared via dynamic covalent boronate reaction exhibit drug loading in a dynamic covalent manner, charge reversal in an acidic microenvironment, and specific drug release in an acidic and/or oxidative microenvironment. These LPNAs are more efficient in eradicating pathogens or cancer cells compared to their free counterparts, both in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Mingxiao Cui, Zhou Fang, Mengdi Song, Taidi Zhou, Yongjie Wang, Kehai Liu
Summary: This study constructed nano-drug delivery systems based on Phragmites rhizoma polysaccharide, which effectively alleviated ulcerative colitis, and explored the significant roles of the Phragmites rhizoma polysaccharide-based nanocarriers in the drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Tao Fang, Zhijian Ye, Xiaona Chen, Yuchen Wang, Jianqin Wan, Hangxiang Wang
Summary: The study demonstrated the development of an injectable self-emulsifying formulation LSN38 NMs, which showed superior therapeutic efficacy against CRC compared to the standard-of-care treatment CPT-11. The findings suggest the potential of converting insoluble chemotherapeutic agents into injectable formulations for improved treatment outcomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Kelsey G. DeFrates, Joakim Engstrom, Nivedina A. Sarma, Athiyya Umar, Jisoo Shin, Jing Cheng, Weiran Xie, Darrin Pochan, Ahmad K. Omar, Phillip B. Messersmith
Summary: Supramolecular self-assemblies have been widely used for drug delivery, but the encapsulation efficiency and release kinetics are limited. In this study, amphiphilic prodrugs based on poly(ethylene glycol) and a proregenerative drug were designed and synthesized to overcome these limitations. The physical state of the prodrugs in water and the release and cellular transport of the drug were found to be strongly influenced by the molecular architecture and the hydrophobic-to-hydrophilic ratio of the conjugates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Mathematics, Applied
Jiaqi Yang
Summary: This paper investigates the shape of the free surface of a liquid filled between two concentric cylinders rotating at different steady speeds. The study focuses on the Newtonian fluid and aims to establish the well-posedness of the steady free boundary problem. Additionally, the convergence of a formal perturbation series obtained by Joseph and Fosdick is proven.
PROCEEDINGS OF THE ROYAL SOCIETY OF EDINBURGH SECTION A-MATHEMATICS
(2022)
Article
Chemistry, Multidisciplinary
Qixiong Zhang, Shanshan Li, Jiandong Ren, Xia He, Houkui Shi, Fuzhong Zhang, Hui Li, Rongsheng Tong
Summary: This study proposes a biomimetic nanoinducer (DOX/ADS NP) based on functional DS for the treatment of melanoma. It achieves better inhibitory effects on melanoma through more specific targeting and sensitive drug release, promoting immune responses associated with immunogenic cell death (ICD). The results demonstrate that DOX/ADS NP significantly inhibits melanoma growth and activates a series of immune responses.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Qiang Nie, Chenwen Li, Yu Wang, Yi Hu, Wendan Pu, Qixiong Zhang, Jiajun Cai, Yongyao Lin, Gang Li, Chenping Wang, Lanlan Li, Yin Dou, Jianxiang Zhang
Summary: Researchers have developed a novel strategy for engineering inflammation-accumulation nanoparticles through phenolic functionalization, which can precisely target and treat inflammatory diseases. These nanoparticles can aggregate in situ in the inflammatory/oxidative microenvironment, leading to enhanced accumulation at inflammatory sites and improved therapeutic effects.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Engineering, Biomedical
Qixiong Zhang, Shanshan Li, Kun Guo, Xuemei Yin, Rongsheng Tong
Summary: CD22 is up-regulated in B-cell lymphoma, and a polysialic acid-modified nanocarrier was designed to target B-cell lymphoma. It enhances the immune response, suppresses tumor growth, and improves survival rate.
ACTA BIOMATERIALIA
(2022)
Review
Medicine, Research & Experimental
Qixiong Zhang, Shanshan Li, Fengyu Chen, Rui Zeng, Rongsheng Tong
Summary: Cellular senescence plays an important negative role in age-associated diseases, and targeting senescent cells is a promising approach for senotherapy. However, existing therapies lack the ability to specifically target senescent cells and often come with side effects. Targeted delivery, as a novel tool, offers great potential for improving senotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Nanoscience & Nanotechnology
Qixiong Zhang, Shanshan Li, Yang Yu, Yuxuan Zhu, Rongsheng Tong
Summary: Pancreatitis is an inflammatory reaction in the pancreatic tissue caused by the activation of pancreatic enzymes, leading to digestion, edema, bleeding, and even necrosis. Severe acute pancreatitis and chronic pancreatitis can cause significant damage to the pancreas with limited treatment options. Nanomedicine technology offers potential tools for the diagnosis and treatment of pancreatitis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Physical
Wen Wu, Xia Hu, Zhen Zeng, Di Wu, Hanmei Li, Hui Li
Summary: In this study, the interaction mechanism between Sorafenib (Sor) and c-MYC Gquadruplexes (G4) was investigated using computer-aided means and experiments. The results showed that Sor binds to the groove of G4 and has a lower affinity for G4 compared to traditional G4 ligands. The research may inspire the screening of new selective c-MYC G4 ligands and the design of drugs with good stability, low toxicity, and specific targeting of G4.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Review
Biochemistry & Molecular Biology
Qixiong Zhang, Shanshan Li, Lin He, Xueting Feng
Summary: Polysialic acid (PSA) is a straight-chain homoglycan that can be used in various applications in the pharmaceutical field due to its non-immunogenicity and biodegradability. It can be employed as a biomaterial for protein polysialylation and tissue engineering, as well as a component in multifunctional drug delivery systems. This article provides an overview of the bioproduction, biofunction, and chemical modification strategies of PSA, as well as the advancements in PSA-based drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Aokai Zhang, Xiuling Yang, Feng Yang, Chunmei Zhang, Qixiong Zhang, Gaigai Duan, Shaohua Jiang
Summary: Polyelectrolyte, a complex physical system, has wide applications in biomedicine, agriculture, and soft robotics. This review presents a comprehensive description of experimental and theoretical studies on the activity coefficient, a crucial thermodynamic property of polyelectrolyte. Experimental methods including direct potentiometric measurement and indirect methods such as isopiestic measurement and solubility measurement were introduced. Various theoretical approaches, including analytical, empirical, and simulation methods, were discussed. Future development challenges were also proposed.
Review
Pharmacology & Pharmacy
Yang Zhao, Haigang Zhang, Qixiong Zhang, Hui Tao
Summary: Neutrophils, as the most abundant white blood cells in human, play a crucial role in treating inflammation-related diseases. However, synthetic polymer nanoparticles face challenges in applications. In recent years, neutrophil-targeted, assisted, or coated nanoparticles have shown better drug effects. Further clinical research is still necessary.
Article
Biochemistry & Molecular Biology
Di Wu, Xia Hu, Zhangyu Cai, Jing Zhang, Fang Geng, Hui Li
Summary: This study investigates the binding behavior and antioxidant activity of the spice extract piperine towards myoglobin (Mb). Results show that an appropriate concentration of piperine can prevent the release of free iron from Mb and cause structural changes that affect antioxidant properties. These findings provide a reference for quality control of plant-origin additives in meat processing and storage.
Article
Chemistry, Multidisciplinary
Haobin Xia, Qiaomei Sun, Na Gan, Pu Ai, Hui Li, Yanfang Li
Summary: Methyl yellow (MY) is extensively used as a colorant in the food sector. Human serum albumin (HSA) plays a crucial role in the absorption, metabolism, distribution, and excretion of MY. Understanding the binding process and physiological interactions between HSA and MY at the molecular level is of great importance. Experimental results indicated that HSA and MY's quenching mechanisms were static, with a binding constant of approximately 10^4 M-1. Hydrophobic forces played a major role in the binding process, and MY was found to bind to site I on HSA. Other changes, such as alterations in alpha-helix content and amino acid microenvironment, were observed. The stability of the system was evaluated using molecular modeling. This study also revealed the inhibitory effects of MY on HSA's esterase-like activity and the influence of Ibf/Phz on the inhibition mechanism. These findings provide valuable insights into the structure, function, and safety evaluation of HSA and MY.
Article
Chemistry, Physical
Wen Wu, Xia Hu, Zhen Zeng, Di Wu, Hanmei Li, Hui Li
Summary: In this study, the interaction mechanism of Sorafenib (Sor) with c-MYC G-quadruplexes (G4) was investigated at the molecular level. Molecular docking and molecular dynamics simulations confirmed the binding of Sor to the groove of G4 and evaluated the effect of ligand binding. Experimental results using UV, fluorescence spectroscopy, and viscosity experiments demonstrated the binding site in the groove. Compared to traditional G4 ligands, Sor showed lower affinity and limited ability to stabilize G4.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Correction
Medicine, Research & Experimental
Qixiong Zhang, Shanshan Li, Lulu Cai, Yuxuan Zhu, Xingmei Duan, Peidu Jiang, Lei Zhong, Kun Guo, Rongsheng Tong
Article
Chemistry, Multidisciplinary
Peng Wang, Yan Wang, Zili Suo, Yuanming Zhai, Hui Li
Summary: In this study, four binary amorphous mixtures of ulipristal acetate (UPA) with cyclodextrins (CDs) were prepared and shown to significantly improve drug solubility, dissolution, and stability. The use of CDs as excipients in amorphous systems provides a new effective strategy for enhancing the properties of poorly soluble drugs.
