Functional Macromolecular Adhesives for Bone Fracture Healing

Compared with traditional internal fixation devices, bone adhesives are expected to exhibit remarkable advantages, such as improved fixation of comminuted fractures and maintained spatial location of fractured scattered bone pieces in treating bone injuries. In this review, different bone adhesives are summarized from the aspects of bone tissue engineering, and the applications of bone adhesives are emphasized. The concepts of liquid scaffold and liquid plate are proposed to summarize two different research directions of bone adhesives. Furthermore, significant advances of bone adhesives in recent years in mechanical strength, osseointegration, osteoconductivity, and osteoinductivity are discussed. We conclude this topic by providing perspectives on the state-of-the-art research progress and future development trends of bone adhesives. We hope this review will provide a comprehensive summary of bone adhesives and inspire more extensive and in-depth research on this subject.

Automated summary

Bone adhesives are expected to have significant advantages in treating bone injuries compared to traditional internal fixation devices. Different research directions of bone adhesives, such as liquid scaffold and liquid plate, are summarized. Recent advances in mechanical strength, osseointegration, osteoconductivity, and osteoinductivity of bone adhesives are discussed.