Article
Immunology
Douwe Jan Dijkstra, A. Inkeri Lokki, Lobke Marijn Gierman, Nicole Veronique Borggreven, Carin van der Keur, Michael Eikmans, Kyra Andrea Gelderman, Hannele Laivuori, Ann-Charlotte FINNPEC Core Investigator Grp, Ann-Charlotte Iversen, Marie-Louise P. van der Hoorn, Leendert Adrianus Trouw
Summary: Preeclampsia (PE) may be associated with decreased levels of C1q and FH, which are related to placental dysfunction and immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Jacelyn M. S. Loh, Haniyeh Aghababa, Thomas Proft
Summary: The human complement system is an important defense mechanism against invasive bacteria. Some bacteria have developed complement evasion strategies to increase their virulence. Complement evasion factors may have potential applications in vaccine and therapeutic development.
MICROBIOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Thajasvarie Naicker, Nalini Govender, Tashlen Abel, Nitalia Naidoo, Merantha Moodley, Yazira Pillay, Shoohana Singh, Olive Pearl Khaliq, Jagidesa Moodley
Summary: HIV infection elevates oxidative stress, apoptosis, angiogenesis, and adhesion markers; while preeclampsia is associated with increased oxidative stress and apoptosis, but decreased angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Anqi Tang, Xin Zhao, Tian Tao, Dengpiao Xie, Bojun Xu, Youqun Huang, Mingquan Li
Summary: Anti-GBM disease is a rare but life-threatening autoimmune disorder. Complement activation plays a significant role in the pathogenesis of the disease, and certain complement factors are associated with the severity of renal injury and act as risk factors for renal outcomes. Patients with both ANCA and anti-GBM antibodies exhibit a unique clinical phenotype, suggesting that complement activation may be a bridge between these two diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angeliki Gardikioti, Theodora-Maria Venou, Eleni Gavriilaki, Evangelia Vetsiou, Ioulia Mavrikou, Konstantinos Dinas, Angelos Daniilidis, Efthymia Vlachaki
Summary: Preeclampsia is a significant cause of maternal and perinatal morbidity and mortality worldwide. Its pathogenesis is associated with an excessive maternal inflammatory response and complement activation. Elevated levels of Willebrand factor antigen and decreased ADAMTS-13 activity are related to the progression and diagnosis of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sonia Fantone, Giovanni Tossetta, Nicoletta Di Simone, Chiara Tersigni, Giovanni Scambia, Fabio Marcheggiani, Stefano R. Giannubilo, Daniela Marzioni
Summary: CD93, also known as complement component C1q receptor, plays a crucial role in placental development, particularly in guiding extravillous cytotrophoblast migration through beta 1-integrin in uterine spiral arteries during placentation. The significant decrease in CD93 expression in third trimester and PE placentas may be linked to impaired migration of extravillous cytotrophoblast cells, suggesting a potential role for CD93 in the early stages of PE onset.
CELL AND TISSUE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Natalia Gebara, Yolanda Correia, Keqing Wang, Benedetta Bussolati
Summary: Angiogenesis, regulated by extracellular vesicles (EVs) from gestational tissues, plays a crucial role in healthy pregnancy and is dysregulated in pregnancy-related diseases like preeclampsia. The use of EVs from placental stem cells shows promise in clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shahab Shahgaldi, Fatemeh Rezaei Kahmini, Seyed Mohammad Moazzeni
Summary: Research shows that mesenchymal stem cell (MSC) therapy can improve recurrent miscarriage by inhibiting excessive complement activation and promoting the production of angiogenic factors. In a mouse model, MSC treatment reduces the rate of miscarriage and improves the intrauterine environment.
MOLECULAR IMMUNOLOGY
(2022)
Article
Clinical Neurology
Frauke Stascheit, Omar Chuquisana, Christian W. Keller, Philip Alexander Ambrose, Sarah Hoffmann, Catharina C. Gross, Sophie Lehnerer, Heinz Wiendl, Nick Willcox, Andreas Meisel, Jan D. Luenemann
Summary: In patients with AChR-Ab(+) MG, there is significantly increased activation of the complement system, which remains present even under standard immunosuppressive therapies but is not evident in patients with MuSK-Abs or seronegative MG. Further exploration of complement inhibition proximal to C5 cleavage is suggested for potential therapeutic benefits in AChR-Ab(+) MG.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Min Liu, Xiaolei Luo, Qin Xu, Hongbiao Yu, Linbo Gao, Rong Zhou, Tao Wang
Summary: The study found that levels of adipsin, C5a, and sENG were significantly increased in the plasma of pregnant women with preeclampsia before delivery. In healthy pregnant women, levels of adipsin, C5a, and sENG increased from the third trimester and remained stable postpartum, but C3a levels increased in the second trimester and remained stable afterward.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Pavel A. Nikitin, Jillian M. DiMuzio, John P. Dowling, Nirja B. Patel, Jamie L. Bingaman-Steele, Baron C. Heimbach, Noeleya Henriquez, Chris Nicolescu, Antonio Polley, Eden L. Sikorski, Raymond J. Howanski, Mitchell Nath, Halley Shukla, Suzanne M. Scheaffer, James P. Finn, Li-Fang Liang, Todd Smith, Nadia Storm, Lindsay G. A. McKay, Rebecca Johnson, Lauren E. Malsick, Anna N. Honko, Anthony Griffiths, Michael S. Diamond, Purnanand Sarma, Dennis H. Geising, Michael J. Morin, Matthew K. Robinson
Summary: Through the study of the B-cell repertoire of recovered COVID-19 patients, we identified human antibodies that can neutralize various variants of SARS-CoV-2. These antibodies form a cocktail that can effectively inhibit viral infection in vitro and in vivo, and induce antiviral responses in the body.
SCIENCE IMMUNOLOGY
(2022)
Article
Cell Biology
Yu Shangguan, Yinglan Wang, Wei Shi, Ruonan Guo, Zhipeng Zeng, Wenlong Hu, Wanxia Cai, Qiang Yan, Yong Xu, Donge Tang, Yong Dai
Summary: This study identified 373 differentially expressed proteins and found functional enrichment related to angiogenesis and the immune system. Potential biomarkers for PE diagnosis and new therapeutic targets were proposed. Additionally, acetylome analysis revealed 700 acetylation sites on 585 proteins, suggesting their involvement in the pathogenesis of PE.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Amelie Kuhn, Jana Riegger, Graciosa Q. Teixeira, Markus Huber-Lang, John D. Lambris, Cornelia Neidlinger-Wilke, Rolf E. Brenner
Summary: Terminal complement complex deposition was found in human degenerated discs. The study investigated the mechanisms and effects of terminal complement activation in annulus fibrosus (AF) cells. Complement inhibitors effectively suppressed anaphylatoxin generation and TCC deposition induced by zymosan. Gene expression of ADAMTS4, MMP1, and COX2 was influenced by C3 and C5 blockade. Degenerated endplate tissue secreted soluble factors that enhanced direct C5 cleavage. These findings suggest the functional involvement of terminal complement activation in disc degeneration and the role of degenerated tissue in complement activation.
Article
Immunology
Boyang Xu, Yuqi Kang, Yujing Du, Weiyi Guo, Li Zhu, Hong Zhang
Summary: This study explores the genetic mechanism underlying aHUS and the impact of CFHR1 isoforms on complement activation and sterile inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Thuy T. Tran, Jasmine Caulfield, Lin Zhang, David Schoenfeld, Dijana Djureinovic, Veronica L. Chiang, Victor Oria, Sarah A. Weiss, Kelly Olino, Lucia B. Jilaveanu, Harriet M. Kluger
Summary: Targeting tumor-associated blood vessels for immune infiltration enhancement has the potential to improve treatment effectiveness, but there is limited data on the effects of anti-angiogenesis on the tumor microenvironment. This study evaluated the combination of anti-PD-1 therapy with either anti-VEGF or lenvatinib in melanoma models and found that both combinations improved survival and decreased tumor growth. The effects on the tumor microenvironment, such as cytokine signaling and immune cell populations, differed between the two combinations. These findings provide valuable insights into the dual targeting of PD-1 and angiogenesis for melanoma treatment.