Review
Obstetrics & Gynecology
Lingli Li, Luping Liu, YuYue Xu
Summary: A meta-analysis explored the potential relationship between hypertensive disease during pregnancy and placenta accreta, finding that hypertensive disease during pregnancy was associated with a lower prevalence of placenta accreta.
REPRODUCTIVE SCIENCES
(2022)
Article
Health Care Sciences & Services
Adila Awaludin, Cherry Rahayu, Nur Aizati Athirah Daud, Neily Zakiyah
Summary: This systematic review assessed the efficacy and safety of antihypertensive drugs in severe hypertension during pregnancy. The results showed that several drugs, including nifedipine and labetalol, can be used for the treatment of severe hypertension in pregnancy. There was no difference in the risk of maternal hypotension, maternal and fetal outcomes, and adverse effects between the drugs, except for dihydralazine and ketanserin, which had more adverse effects.
Review
Cell Biology
Megan A. Opichka, Matthew W. Rappelt, David D. Gutterman, Justin L. Grobe, Jennifer J. McIntosh
Summary: Preeclampsia is a life-threatening cardiovascular disorder associated with pregnancy, potentially caused by dysfunction in maternal and placental blood vessels and other factors. Current gaps in knowledge include detailed understanding of its underlying causes and effective treatment options.
Article
Peripheral Vascular Disease
Anna Kivioja, Elli Toivonen, Jaakko Tyrmi, Sanni Ruotsalainen, Samuli Ripatti, Heini Huhtala, Tiina Jaaskelainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Tanja Saarela, Hannele Laivuori
Summary: The study found that the polygenic risk score for blood pressure (BP-PRS) is associated with an increased risk of preeclampsia and its severe subtypes, with women with high BP-PRS presenting higher blood pressure values during pregnancy.
Review
Obstetrics & Gynecology
Lingli Li, Luping Liu, YuYue Xu
Summary: This study conducted a meta-analysis and found that hypertension in pregnancy may be associated with a lower prevalence of placenta accreta spectrum.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Pharmacology & Pharmacy
Nian-Jia Deng, Chen-Yang Xian-Yu, Rui-Zheng Han, Cheng-Yang Huang, Yu-Tong Ma, Hui-Jun Li, Teng-Yu Gao, Xin Liu, Chao Zhang
Summary: This network meta-analysis indicates that nifedipine should be recommended as a strategy for blood pressure management in pregnant women with severe hypertension. However, the conventional pharmaceuticals, labetalol and hydralazine, showed limited efficacy, and the instability of hydralazine reducing blood pressure and the high benefit of labetalol with high dosages intakes should be of concern to clinicians.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Obstetrics & Gynecology
Shiva Hadizadeh, Elnaz Shahmohamadi, Naser Khezerlouy-Aghdam, Leida Heidary, Azadeh Tarafdari, Sedigheh Hantoushzadeh, Aryan Ayati, Laleh Foroutani, Hossein Ahmadi-tafti, Reza Mohseni-badalabadi, Hamed Vahidi, Alireza Hadizadeh, Sanaz Mousavi
Summary: White coat hypertension is associated with the incidence of hypertensive disorders during pregnancy. Accurate diagnosis and management through 24-hour ambulatory blood pressure monitoring are recommended.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Kyle R. Roell, Quaker E. Harmon, Kari Klungsoyr, Anna E. Bauer, Per Magnus, Stephanie M. Engel
Summary: This study investigated changes in gestational blood pressure trajectories among preeclampsia cases, finding that individuals with a more rapid increase in blood pressure and those with a high starting blood pressure experienced worse pregnancy outcomes.
Article
Obstetrics & Gynecology
Young Mi Jung, Gyu Chul Oh, Eunjin Noh, Hae-Young Lee, Min-Jeong Oh, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee, Geum Joon Cho
Summary: Hypertension before pregnancy, specifically stage I hypertension, increases the risk of obstetric complications. Lower pre-pregnancy blood pressure is associated with better maternal and neonatal outcomes. Pregnant women with stage I hypertension prior to pregnancy should be carefully monitored for adverse outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Peripheral Vascular Disease
Sonia Johnson, Sanne Gordijn, Stefanie Damhuis, Wessel Ganzevoort, Mark Brown, Peter von Dadelszen, Laura A. Magee, Asma Khalil
Summary: This study used the Delphi procedure to reach consensus on diagnostic criteria and monitoring strategies for white coat hypertension in pregnancy.
Article
Environmental Sciences
Emma Preston, Marie-France Hivert, Abby F. Fleisch, Antonia M. Calafat, Sharon K. Sagiv, Wei Perng, Sheryl L. Rifas-Shiman, Jorge E. Chavarro, Emily Oken, Ami R. Zota, Tamarra James-Todd
Summary: This study found that exposure to certain PFAS may increase the risk of gestational hypertension during pregnancy, with potential implications for maternal and child health outcomes.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Psychiatry
Margaret H. Bublitz, Elena Salmoirago-Blotcher, Laura Sanapo, Nina Ayala, Niharika Mehta, Ghada Bourjeily
Summary: This pilot randomized clinical trial suggests that prenatal mindfulness training is feasible and acceptable, and may be a useful adjunctive preventative treatment for hypertensive disorders of pregnancy among at-risk pregnant patients.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Medicine, General & Internal
Marta Peksa, Alexandra Kamieniecki, Anna Gabrych, Anna Lew-Tusk, Krzysztof Preis, Malgorzata Swiatkowska-Freund
Summary: Pregnancy-induced hypertension and pre-eclampsia are serious complications of pregnancy, and the abnormality of the placental barrier is believed to be involved in their pathogenesis. This study found a correlation between the discontinuity of E-cadherin expression and the development of pre-eclampsia, suggesting that it could be an immunohistochemical marker.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Michalina Bralewska, Lidia Biesiada, Mariusz Grzesiak, Magda Rybak-Krzyszkowska, Hubert Huras, Agnieszka Gach, Tadeusz Pietrucha, Agata Sakowicz
Summary: This study reveals that chromogranin A gene expression level is associated with preeclampsia for the first time. The depletion in catestatin level might be a marker of developing preeclampsia. Further studies may unravel the role of Chromogranin A in the discussed disease.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Endocrinology & Metabolism
Clive J. Petry, Keith A. Burling, Peter Barker, Ieuan A. Hughes, Ken K. Ong, David B. Dunger
Summary: The study revealed associations between maternal circulating DLK1 levels and fetal DLK1 genotypes, maternal insulin resistance and secretion, as well as offspring size at birth. Maternal DLK1 concentration was found to have a partial paternal or placental origin, potentially leading to increased maternal circulating DLK1 levels and stimulation of maternal insulin resistance and compensatory hyperinsulinemia during pregnancy, thereby promoting fetal growth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Antigoni Eleftheriou, Clive J. Petry, Ieuan A. Hughes, Ken K. Ong, David B. Dunger
Summary: The study found variable associations of DR3, DR4, and DQ8 alleles with growth measures and IGF-I levels in infants from the general population, which could explain the heterogeneous growth trajectories observed in genetically at-risk cohorts. These findings suggest distinct mechanisms involving endocrine pathways related to the HLA-conferred type 1 diabetes risk.
Article
Nutrition & Dietetics
Clive J. Petry, Ken K. Ong, Ieuan A. Hughes, David B. Dunger
Summary: Iron supplementation during pregnancy was found to be associated with an increased risk of developing GDM and impacting offspring birth weight and adiposity. These findings suggest that iron supplementation may mediate the effects of multiple micronutrient supplementation during pregnancy in a high-income country.
Article
Nutrition & Dietetics
Laurentya Olga, Clive J. Petry, Janna A. van Diepen, Philippa M. Prentice, Ieuan A. Hughes, Jacques Vervoort, Jos Boekhorst, Maciej Chichlowski, Gabriele Gross, David B. Dunger, Ken K. Ong
Summary: The study aims to investigate the impact of early growth and nutrition on future health and metabolic risks through long-term observation and data collection of 2229 mother-infant pairs. Strict inclusion criteria were applied, only retaining exclusively breastfed infants meeting the requirements for analysis.
Article
Multidisciplinary Sciences
Clive J. J. Petry, Laurentya Olga, Ieuan A. A. Hughes, Ken K. K. Ong
Summary: Maternal iron supplementation during pregnancy may have an impact on newborn size and adiposity, but these effects disappear during infancy. However, there is some evidence to suggest that iron supplementation during pregnancy may have long-term effects on blood pressure in mid-childhood.
Article
Endocrinology & Metabolism
Clive J. Petry, Ieuan A. Hughes, Ken K. Ong
Summary: This study found that women carrying a male fetus had higher insulin sensitivity and secreted more insulin in the fasting state. These results suggest that fetal sex may modify the maternal glucose-insulin axis.
BIOLOGY OF SEX DIFFERENCES
(2022)
Review
Nutrition & Dietetics
Clive J. Petry
Summary: Iron supplementation in pregnancy may increase the risk of gestational diabetes, particularly in women who are already iron-replete. However, current evidence on this topic is contradictory, and the magnitude of any increased risk appears relatively small, urging caution in interpreting the results.
Article
Endocrinology & Metabolism
Yanislava Karusheva, Clive J. Petry, Nirmani Yasara, Dulani Kottahachchi, Anuja Premawardhena, Peter Barker, Keith Burling, Naveed Sattar, Paul Welsh, Sachith Mettananda, Stephen O'Rahilly
Summary: GDF15 is a stress-induced hormone that can act on the brain to reduce food intake and body weight, while affecting neuroendocrine function. GDF15 levels are significantly elevated in β-thalassaemia patients and show a curvilinear relationship with BMI. The negative correlation between GDF15 and IGF1 levels may reflect the neuroendocrine impact of GDF15 or an indirect effect via impaired nutritional state.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Antigoni Eleftheriou, Ken K. Ong, Ieuan A. Hughes, Clive J. Petry
Summary: The study found that vitamin D metabolism genes DHCR7 and CYP2R1 may influence leptin and IGF-1 levels in infancy through the effects on growth-related hormones. These findings indicate a potential developmental role of vitamin D mediated by growth-related hormones and its implications for the onset of type 1 diabetes autoimmunity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Laurentya Olga, Janna A. van Diepen, Maciej Chichlowski, Clive J. Petry, Jacques Vervoort, David B. Dunger, Guus A. M. Kortman, Gabriele Gross, Ken K. Ong
Summary: This study investigated the origins and determining factors of butyrate in human milk and its influence on infant weight gain. The results showed that higher concentrations of butyrate in human milk were associated with lower infant weight and adiposity, especially in younger infants. Furthermore, the study found an inverse correlation between butyrate concentration and milk intake volume, suggesting a potential mechanism involving appetite regulation and modulation of milk intake.
Article
Endocrinology & Metabolism
Robert Moulder, Tommi Valikangas, M. Karoliina Hirvonen, Tomi A. Suomi, Caroline A. Brorsson, Niina Lietzen, Sylvaine F. A. Bruggraber, Lut Overbergh, David B. Dunger, Mark Peakman, Piotr J. Chmura, Soren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Laura L. Elo, Riitta Lahesmaa
Summary: There is a growing need for markers that could indicate the decline in beta cell function in type 1 diabetes. This study evaluated a panel of proteins in serum from newly diagnosed individuals and found associations between certain proteins and beta cell function. The findings suggest that these proteins may be useful in future studies of beta cell function in type 1 diabetes.
Article
Endocrinology & Metabolism
Danielle L. L. Jones, Clive J. J. Petry, Keith Burling, Peter Barker, Elizabeth H. H. Turner, Laura C. C. Kusinski, Claire L. L. Meek
Summary: The aim of this study was to assess if fasting and post-load incretin concentrations were predictive of pregnancy insulin and glucose concentrations. The results showed that fasting plasma GLP-1 concentrations were associated with plasma insulin concentrations, but not with glucose concentrations. GIP concentrations were not associated with insulin or glucose concentrations.
ACTA DIABETOLOGICA
(2023)
Article
Biology
Clive J. Petry, Ken K. Ong, Ieuan A. Hughes, David B. Dunger
Summary: The study found that folic acid supplementation during pregnancy did not contribute to the previously observed increases in offspring size at birth and adiposity, nor the higher risk of gestational diabetes associated with multiple micronutrient supplementation.
BMC RESEARCH NOTES
(2021)