Article
Clinical Neurology
Fadi Rofo, Silvio R. Meier, Nicole G. Metzendorf, Jamie Morrison, Alex Petrovic, Stina Syvanen, Dag Sehlin, Greta Hultqvist
Summary: In this study, a Bispecific-multivalent antibody format capable of passing the blood-brain barrier and targeting a wide range of sizes of soluble A beta aggregates was demonstrated.
Article
Polymer Science
Yu Zhao, Qiushi Li, Qingqing Huang, Yang Liu
Summary: A self-destructive nanoscavenger (SDNS) has been developed to capture and deliver soluble beta-amyloid aggregates (sA beta s) into microglial lysosomes via hydrogen-bonding interactions. The SDNS then self-destruction within lysosomes and stimulates autophagy, promoting the degradation of neurotoxic sA beta s. Furthermore, enhanced autophagy suppresses the secretion of inflammatory factors by microglia, which is induced by internalized sA beta s. This synergistic approach shows potential as a therapeutic strategy for Alzheimer's disease.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Neurosciences
Sebastiaan De Schepper, Judy Z. Z. Ge, Gerard Crowley, Lais S. S. Ferreira, Dylan Garceau, Christina E. E. Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J. J. Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong
Summary: Microglia mediate aberrant synapse engulfment in Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Here the authors show a perivascular cells-to-microglia crosstalk that induces microglia phagocytic state resulting in synapse engulfment in two mouse models of AD.
NATURE NEUROSCIENCE
(2023)
Review
Neurosciences
Carmen Romero-Molina, Francesca Garretti, Shea J. Andrews, Edoardo Marcora, Alison M. Goate
Summary: Genome-wide association studies and functional genomics studies have provided insights into the role of specific cell types, genes, and pathways in the risk of Alzheimer's disease (AD), particularly highlighting the involvement of microglia in AD pathogenesis.
Article
Immunology
Xuan Sheng, Yunling Yao, Ruizhi Huang, Ying Xu, Yifei Zhu, Linting Chen, Lianshuai Zhang, Wanbing Wang, Rengong Zhuo, Dan Can, Che-Feng Chang, Yun-Wu Zhang, Huaxi Xu, Guojun Bu, Li Zhong, Xiao-Fen Chen
Summary: The study showed that sTREM2 fragments 41-81 and 51-81 enhanced cell viability and inflammatory responses in primary microglia; fragment 41-81 was more efficient than 51-81 in ameliorating amyloid-related pathology and is a promising candidate for AD therapy.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Qingyong Li, Jun Peng, Yuelian Luo, Jiaxin Zhou, Tailin Li, Lin Cao, Shuling Peng, Zhiyi Zuo, Zhi Wang
Summary: This study found that far infrared (FIR) light can reduce A beta burden, alleviate neuroinflammation, and improve learning and memory impairment in AD mice. FIR light enhances mitochondrial oxidative phosphorylation pathway to increase ATP production, thereby enhancing the phagocytosis and clearance of A beta. These findings suggest that FIR light treatment may be a potential therapeutic strategy for AD.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Kaitlin B. Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M. Simone, Jennifer S. Rabin, Renaud La Joie, Adam M. Brickman, Kristen Dams-O'Connor, Priya Palta, Raj G. Kumar, Kristen M. George, Claudia L. Satizabal, Julie Schneider, Judy Pa
Summary: Females with Alzheimer's disease are more susceptible than males, and microglial activation plays an important mediating role in females but not males. This finding is crucial for understanding the pathogenesis of Alzheimer's disease and providing precision health care.
Article
Clinical Neurology
David W. Nauen, Juan C. Troncoso
Summary: The research examined lymph nodes resected during cancer treatment or staging and found that Aβ-labeled cells were present, with cervical lymph nodes having more labeled cells than inguinal nodes. This observation supports the hypothesis that the glymphatic system contributes to the clearance of Aβ from the human brain.
ALZHEIMERS & DEMENTIA
(2022)
Review
Immunology
Lauren H. Fairley, Jia Hui Wong, Anna M. Barron
Summary: Alzheimer's disease is a terminal neurodegenerative disease with innate immune dysfunction playing a significant role in its pathogenesis. Microglia, the effector cells of innate immunity in the brain, have important immune functions that are energetically demanding and regulated by mitochondria. Genetic risk factors and pathology associated with AD can impair microglial metabolic programming, leading to immune dysfunction. Targeting microglial metabolism may offer a therapeutic window for treating Alzheimer's disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Deepali Singh
Summary: Neuroinflammation is caused by the misfiring of immune cells in the central nervous system and can have both positive and negative effects on neurodevelopment and post-injury tissue. Chronic or uncontrolled inflammatory responses may lead to neurodegenerative diseases, while abnormal activation of glial cells can mediate neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Kurti Aishe, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu
Summary: In this study, a Trem2 H157Y knock-in mouse model was generated to investigate the effects of this mutation on TREM2 processing, synaptic function, and AD-related amyloid pathologies. The results showed that Trem2 H157Y increased TREM2 shedding, resulting in elevated soluble TREM2 levels in the brain and serum. Furthermore, Trem2 H157Y accelerated amyloid-beta clearance and reduced amyloid burden in the presence of amyloid pathology. These findings suggest that TREM2 H157Y may increase AD risk through an amyloid-independent pathway.
MOLECULAR NEURODEGENERATION
(2023)
Article
Clinical Neurology
Andrew M. Stern, Lei Liu, Shanxue Jin, Wen Liu, Angela L. Meunier, Maria Ericsson, Michael B. Miller, Megan Batson, Tingwan Sun, Sagar Kathuria, David Reczek, Laurent Pradier, Dennis J. Selkoe
Summary: Researchers have developed a new monoclonal antibody that specifically targets neurotoxic oligomers of amyloid-beta peptide. This antibody has a unique property that allows it to isolate soluble amyloid-beta aggregates from Alzheimer's disease brain without denaturation. These aggregates may be the principal neurotoxic forms of amyloid-beta in Alzheimer's disease, and they can lead to various pathological events.
Review
Geriatrics & Gerontology
Pei Ou-Yang, Zhi-Yu Cai, Zhong-Hao Zhang
Summary: This review focuses on the association between microglial autophagy and Alzheimer's disease pathology. It discusses the impact of impaired microglial autophagy on the inflammatory response, defective clearance, propagation of Aβ and Tau, and synaptic dysfunction. The study suggests that inducing microglial autophagy may have great potential in the development of drugs for Alzheimer's disease.
Article
Clinical Neurology
Lei Liu, Hyunchang Kwak, Trebor L. Lawton, Shan-Xue Jin, Angela L. Meunier, Yifan Dang, Beth Ostaszewski, Alison C. Pietras, Andrew M. Stern, Dennis J. Selkoe
Summary: The study developed a new method for detecting and quantifying soluble oligomers of amyloid beta protein in human plasma. The method is highly sensitive, cost-effective, and suitable for high throughput analysis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Hannah Ennerfelt, Elizabeth L. Frost, Daniel A. Shapiro, Coco Holliday, Kristine E. Zengeler, Gabrielle Voithofer, Ashley C. Bolte, Catherine R. Lammert, Joshua A. Kulas, Tyler K. Ulland, John R. Lukens
Summary: Recent studies have highlighted the critical roles of microglia and their receptors in controlling neurotoxic material in neurodegenerative diseases. SYK plays an important role in neuroprotective functions of microglia, with its deletion exacerbating AD deposition and neuropathology. In addition, SYK regulates microglial phagocytosis and DAM acquisition in demyelinating disease.
Article
Chemistry, Multidisciplinary
Qi Liu, Tian-Xing Zhang, Yadan Zheng, Chun Wang, Ziyao Kang, Yu Zhao, Jingshan Chai, Hua-Bin Li, Dong-Sheng Guo, Yang Liu, Linqi Shi
Summary: CENP, a novel nanoparticle, co-delivers molecular drugs and therapeutic genes for interference-free gene-drug combination cancer therapy, showing significantly enhanced anti-tumor effects. With the potential to be a universal platform adaptable for various drug and gene combinations, CENP holds promise for the development of effective cancer treatments.
Article
Engineering, Biomedical
Meng Qian, Qi Liu, Yan Wei, Zhikun Guo, Qiang Zhao
Summary: Cardiovascular diseases are a leading cause of mortality worldwide, and nitric oxide plays a vital role in regulating cardiovascular function. Research on the in situ conversion of endogenous NO donors catalysed by functional surfaces for cardiovascular stents has shown promising results in improving endothelium healing and long-term patency.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ying Wang, Zhanzhan Zhang, Chunxiong Zheng, Xinzhi Zhao, Yadan Zheng, Qi Liu, Yang Liu, Linqi Shi
Summary: Multistage adaptive nanoparticles (MAN) with a core-shell structure made of responsive polymers can adapt to the biological microenvironment, achieve stability in blood circulation, accumulate in tumor tissues, release drugs effectively in cells, and suppress tumors with reduced systemic toxicity. MAN can load various hydrophobic drugs, providing a general strategy for targeted delivery of hydrophobic drugs to overcome multiple biological barriers and enhance chemotherapy efficacy.
Article
Engineering, Environmental
Chun Wang, Qi Liu, Zhanzhan Zhang, Ying Wang, Yadan Zheng, Jialei Hao, Xinzhi Zhao, Yang Liu, Linqi Shi
Summary: This study introduces a nano-scale quaternary polyplex (NQP) for optimized delivery of siRNA targeting cancer cells, leading to efficient gene silencing and tumor growth inhibition in experimental models.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Ziyao Kang, Chun Wang, Zhanzhan Zhang, Qi Liu, Yadan Zheng, Yu Zhao, Zheng Pan, Qiushi Li, Linqi Shi, Yang Liu
Summary: The study presents a polymeric carrier for antimicrobial peptides that enhances their anticancer efficacy while reducing potential side effects.
ADVANCED MATERIALS
(2022)
Article
Engineering, Environmental
Zheng Chunxiong, Zhao Xinzhi, Wang Ying, Zhao Yu, Zheng Yadan, Zhang Zhanzhan, Liu Qi, Liu Yang, Shi Linqi
Summary: In this study, an immune modulating nanoparticle (IMNP) was designed to achieve spatial control of drug release sites and synergistically deplete tumor-associated macrophages (TAMs). The results showed that the IMNP effectively eliminated TAMs and improved the tumor environment, leading to a significant enhancement of the anti-tumor efficacy of immune checkpoint blocking therapies.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Ziyao Kang, Qi Liu, Zhanzhan Zhang, Yadan Zheng, Chun Wang, Zheng Pan, Qiushi Li, Yang Liu, Linqi Shi
Summary: A series of arginine-rich cell penetrating polymers are designed and synthesized to efficiently deliver biomacromolecules or drugs across the cell membrane by inducing pore formation on the cell membrane, thus avoiding endosomal entrapment. PTn-R2-C6, a polymer with two arginine residues and a flexible hexanoic acid linker in each side chain, shows excellent pore-forming ability and achieves higher transfection efficiency and lower cytotoxicity compared to the gold-standard transfection reagent PEI 25K. These findings suggest that PTn-R2-C6 has great potential as a safe and efficient gene transfection reagent for various applications including disease treatments, vaccine development, and biomedical research.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Tian Hao, Meng Qian, Yating Zhang, Qi Liu, Adam C. Midgley, Yangping Liu, Yongzhe Che, Jingli Hou, Qiang Zhao
Summary: Acute myocardial infarction is the leading cause of death worldwide. Researchers have synthesized a hydrogel that can release nitric oxide to modulate ROS/NO imbalance after ischemia/reperfusion injury, effectively alleviating cardiac damage and improving cardiac function. The hydrogel protects against oxidative stress by activating the antioxidant defense system and reducing inflammation.
Article
Cell Biology
Fei Wang, Kang Qin, Kai Wang, He Wang, Qi Liu, Meng Qian, Shang Chen, Yijin Sun, Jingli Hou, Yongzhen Wei, Yanhua Hu, Zongjin Li, Qingbo Xu, Qiang Zhao
Summary: A bio-hybrid vascular graft with local delivery of nitric oxide (NO) has been fabricated by incorporating a nitrate-functionalized prosthesis into a decellularized porcine vein graft, which efficiently promotes vascular regeneration and attenuates adverse pathologic remodeling in rabbit and mouse models.
Article
Engineering, Biomedical
Chun Wang, Jian Xiao, Xinyue Hu, Qi Liu, Yadan Zheng, Ziyao Kang, Dongsheng Guo, Linqi Shi, Yang Liu
Summary: Biological barriers are a significant limitation in drug delivery systems, reducing their efficiency and causing undesired therapeutic effects. This study introduces a liquid core nanoparticle (LCN) composed of a polymer-encapsulated edible oil droplet. The LCN exhibits high mechanical softness and deformability, allowing it to effectively penetrate through biological barriers and deliver drugs, presenting a potential platform for disease treatments.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Ruoheng Chai, Qi Liu, Wenwei Liu, Zhancheng Li, Hua Cheng, Jianguo Tian, Shuqi Chen
Summary: In this Perspective, recent advancements in planar nanophotonics involving localized resonances, nonlocal modes, and their couplings are reviewed. The intriguing physical effects and applications related to local and/or nonlocal modes are discussed, along with large-area optimization strategies for directly simulating optical responses. Several current challenges and future directions in this attractive field are summarized as well.
Article
Chemistry, Multidisciplinary
Jin-Juan Duan, Ping-Sheng Luo, Qi Liu, Feng-Ao Sun, Li-Ming Zhu
Summary: The proposed CP-KEDL system is a method for complex product modeling design based on Long Short-Term Memory (LSTM) neural network and Kansei Engineering (KE). It transforms product modeling features into feature codes with sequence characteristics using an improved MA method and establishes a mapping model between perceptual images and modeling features based on the LSTM neural network. The experimental results show that the proposed method effectively addresses the modeling design problem of complex products, improves design satisfaction, and shortens the R&D cycle of CP industrial design.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Qi Liu, Guangbo Ji, Yushu Chu, Tian Hao, Meng Qian, Qiang Zhao
Summary: A hybrid prodrug was synthesized to achieve the combined delivery of nitric oxide and hydrogen sulfide, providing effective treatment for heart failure post-myocardial infarction.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Yadan Zheng, Zhanzhan Zhang, Qi Liu, Ying Wang, Jialei Hao, Ziyao Kang, Chun Wang, Xinzhi Zhao, Yang Liu, Linqi Shi
Summary: An immunomodulating nano-photosensitizer was developed to enhance reactive oxygen species production and regulate the immunosuppressive tumor microenvironment for improved photoimmunotherapy. Through co-delivery of immunomodulators, this platform showed potential for efficient and precise treatment of tumors.
BIOMATERIALS SCIENCE
(2021)