Article
Immunology
Reza Khoshbakht, Susan Panahi, Alireza Neshani, Mahdis Ghavidel, Kiarash Ghazvini
Summary: Acinetobacter baumannii is becoming increasingly resistant to antibiotics, including carbapenems. Colistin is currently used as a last resort against resistant strains, but reports of Colistin-resistant phenotypes are emerging. Quorum quenching, which disrupts bacteria's communication and biofilm formation, shows promise as an alternative method to combat resistance in A. baumannii.
MICROBIAL PATHOGENESIS
(2023)
Article
Microbiology
Fatemeh Latifi, Ali Hashemi, Behrooz S. Kalani, Iraj Pakzad, Ali Hematian
Summary: The role of the toxin-antitoxin (TA) system in the formation of persistence cells of Acinetobacter baumannii isolates was investigated in this study. The abkBA system was found in all isolates, and 4% of isolates formed persister cells. The expression level of the abkB gene in persistent isolates showed a sevenfold increase compared to nonpersistent isolates. The abkBA toxin-antitoxin system is likely involved in the persistence phenotype in clinical isolates of Acinetobacter baumannii.
FUTURE MICROBIOLOGY
(2023)
Article
Infectious Diseases
Camila Pimentel, Casin Le, Marisel R. Tuttobene, Tomas Subils, Krisztina M. Papp-Wallace, Robert A. Bonomo, Marcelo E. Tolmasky, Maria Soledad Ramirez
Summary: The study exposed different Acinetobacter baumannii strains to human serum albumin (HSA) and human serum (HS) to evaluate their response in terms of antimicrobial resistance, biofilm formation, and quorum sensing. The results showed varying gene expression levels and responses among different strains when exposed to HSA and HS, indicating different adaptative responses in infecting A. baumannii strains.
Article
Immunology
Jan Vogel, Lisa Jansen, Rita Setroikromo, Francis M. Cavallo, Jan Maarten van Dijl, Wim J. Quax
Summary: Acinetobacter baumannii is an opportunistic Gram-negative bacterial pathogen that poses a threat to frail patients worldwide. It has high tolerance to environmental stresses and broad-spectrum antibiotic resistance, making it difficult to eradicate. The formation of biofilms, regulated by multiple mechanisms including quorum-sensing, plays a key role in antibiotic tolerance. This study demonstrates that PvdQ from Pseudomonas aeruginosa can reduce biofilm formation by A. baumannii and enhance the effect of gentamicin treatment. Additionally, PvdQ administration prolongs the survival of Galleria mellonella larvae. The findings suggest that acylase-mediated cleavage of quorum-sensing signaling molecules can limit the progression of A. baumannii infections.
MICROBES AND INFECTION
(2022)
Article
Immunology
Nayeong Kim, Joo Hee Son, Kyeongmin Kim, Hyo Jeong Kim, Yoo Jeong Kim, Minsang Shin, Je Chul Lee
Summary: This study identified a DksA ortholog in Acinetobacter baumannii and found that the increment dksA mutant strain exhibited changes in morphology, growth, surface motility, and increased biofilm formation. Additionally, the mutant strain showed decreased bacterial burden and milder histopathological changes in the lungs of mice, indicating a potential role of DksA in virulence regulation.
Article
Multidisciplinary Sciences
Shahira A. ElBanna, Nayera A. Moneib, Ramy K. Aziz, Reham Samir
Summary: A novel CptBA-like type IV TA system was identified in Acinetobacter baumannii, confirming its TA nature. The system was found to be downregulated under oxidative and antibiotic stress, suggesting a possible role in response to antibiotics and stress factors.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Infectious Diseases
Dinusha Chathurangi Rajapaksha, Shan Lakmal Edirisinghe, Chamilani Nikapitiya, Ilson Whang, Mahanama De Zoysa
Summary: In this study, it was found that the antimicrobial peptide octopromycin can inhibit the biofilm and quorum-sensing of Acinetobacter baumannii. Octopromycin reduced biofilm mass, caused a collapse in biofilm architecture, and successfully killed antibiotic-resistant persister cells. It also inhibited violacein production in Chromobacterium violaceum and alginate production, surface movements, and twitching motility of A. baumannii.
Review
Microbiology
Shan Zhong, Songzhe He
Summary: Acinetobacter baumannii, a Gram-negative opportunistic nosocomial pathogen, poses a serious threat to public health due to its resistance to common antimicrobials and tolerance to desiccation. Bacteria regulate their virulence behavior through a phenomenon called quorum sensing, and the use of quorum sensing inhibitors or quorum quenching enzymes has been developed to reduce bacterial virulence and drug resistance pressure. These inhibitors or enzymes have the potential to inhibit bacterial quorum sensing and biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Ping Wang, Ren-Qing Li, Lei Wang, Wen-Tao Yang, Qing-Hua Zou, Di Xiao
Summary: This study utilized glycoproteomics analysis to identify 164 proteins with differential expression in multidrug-resistant and drug-susceptible Acinetobacter baumannii clinical isolates. The proteins were classified into six groups, providing insight into the mechanism of antibiotic resistance of multidrug-resistant Acinetobacter baumannii. Validation at the transcription level showed that four selected proteins correlated positively with the protein level.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Engineering, Environmental
Tomislav Ivankovic, Helena Turk, Jasna Hrenovic, Zdravko Schauperl, Marica Ivankovic, Antonia Ressler
Summary: A novel biomaterial utilizing silver ions within the hydroxyapatite lattice has been developed to address the issue of multi-drug resistance in Acinetobacter baumannii infections. The antibacterial activity of the biomaterial was examined against A. baumannii clinical isolates, showing strong efficacy. The concentration of silver ions in the biomaterial was found to impact the antibacterial effect.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Microbiology
Shahla Shabazi, Ali Shivaee, Marzieh Nasiri, Maryam Mirshekar, Smaira Sabzi, Omid K. Saria
Summary: This study investigated the impact of zinc oxide nanoparticles (ZnO-NPs) on the expression of toxin-antitoxin (TA) system genes in multidrug-resistant Acinetobacter baumannii. The presence of ZnO-NPs was found to decrease the expression of the studied genes. These findings have important implications for the development of targeted strategies against multidrug-resistant pathogens using nanotechnology.
JOURNAL OF BASIC MICROBIOLOGY
(2023)
Article
Microbiology
Kusumita Acharya, Sonjukta Borborah, Abhishek Chatterjee, Mallika Ghosh, Arijit Bhattacharya
Summary: Bacterial pigments are secondary metabolites with potential antimicrobial, anticancer, and immunomodulation effects. This study found that prodigiosin, a bacterial pigment, is a potent quorum quencher and can disrupt biofilm formation in Acinetobacter baumannii. Prodigiosin also enhances the antibiotic action against A. baumannii biofilms. The results suggest that prodigiosin may be a promising therapeutic strategy for combating A. baumannii infection.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Soha Lotfy Elshaer, Moataz A. Shaldam, Mona Shaaban
Summary: This study found that non-steroidal anti-inflammatory drugs ketoprofen, piroxicam, and indomethacin can inhibit the quorum sensing of Acinetobacter baumannii and suppress its QS-related virulence factors. These drugs may provide potential options for combating the pathogenesis of A. baumannii.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Cell Biology
Sonia Jain, Arghya Bhowmick, Bohyun Jeong, Taeok Bae, Abhrajyoti Ghosh
Summary: This study investigates the impact of the mazEF toxin-antitoxin module on biofilm formation, pathogenesis, and antibiotic resistance in a clinical MRSA strain. The study showed that the activated MazF toxin promotes cell death and lysis for biofilm formation and leads to resistance to antibiotics like oxacillin, daptomycin, and vancomycin.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Immunology
Sandra Sanchez-Urtaza, Alain Ocampo-Sosa, Ainhoa Molins-Bengoetxea, Mohammed A. A. El-Kholy, Marta Hernandez, David Abad, Sherine M. M. Shawky, Itziar Alkorta, Lucia Gallego
Summary: This study investigated the genetic characteristics and antimicrobial susceptibility profile of multidrug resistant Acinetobacter baumannii clinical isolates obtained from hospitals in Alexandria, Egypt. The results showed resistance to multiple antibiotics and the presence of various antibiotic resistance genes and virulence factors. The study highlights the importance of investigating molecular epidemiology to control the spread of these multidrug resistant isolates.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)