Article
Obstetrics & Gynecology
Elizabeth L. Wolfe, Denis Vaughan, Wendy Craig, Brianna Amaral, Alan Penzias, Denny Sakkas, Thomas L. Toth
Summary: This study compared the live birth rates in modified natural and programmed single blastocyst frozen embryo transfer cycles. The results showed no difference in live birth rates between programmed cycles using intramuscular progesterone or a combination of vaginal progesterone and intramuscular progesterone compared with modified natural cycles. However, the live birth rate decreased in programmed cycles that used exclusively vaginal progesterone. This study demonstrates that modified natural cycles and optimized programmed cycles have equivalent live birth rates.
FERTILITY AND STERILITY
(2023)
Article
Multidisciplinary Sciences
Abdelhamid Benmachiche, Sebti Benbouhedja, Abdelali Zoghmar, Peter Samir Hesjaer Al Humaidan
Summary: The multivariate analysis suggests that midluteal progesterone level seems to impact live birth rates more than preovulatory progesterone level in women undergoing IVF treatment followed by fresh embryo transfer.
Article
Obstetrics & Gynecology
C. Maignien, M. Bourdon, L. Marcellin, J. Guibourdenche, A. Chargui, C. Patrat, G. Plu-Bureau, C. Chapron, P. Santulli
Summary: BMI, parity, and non-European geographic origin are factors associated with low serum progesterone levels on the day of frozen embryo transfer in hormone replacement therapy (HRT) cycles. This study highlights the importance of identifying these factors to predict which patients would benefit from tailored progesterone supplementation.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Christos A. Venetis
Summary: Embryo cryopreservation is an important part of ART, and the freeze-all strategy has shown higher live birth rates in high responders. However, there is no significant difference in normal responders. The freeze-all policy reduces the risk of ovarian hyperstimulation syndrome, but both strategies have their own risks and there is no clear safer approach.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Kate Devine, Kevin S. Richter, Samad Jahandideh, Eric A. Widra, Jeffrey L. McKeeby
Summary: The study compared vaginal progesterone with intramuscular progesterone in terms of live birth rates from frozen embryo transfer (FET) and found that women receiving only vaginal progesterone had significantly lower live birth rates and higher miscarriage rates compared to those receiving intramuscular progesterone or combination treatment. Vaginal progesterone supplemented with intramuscular progesterone every third day was shown to be noninferior to daily intramuscular progesterone, offering an effective alternative regimen with fewer injections.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Jun Shuai, Qiao-li Chen, Wen-hong Chen, Wei-wei Liu, Guo-ning Huang, Hong Ye
Summary: Maternal age, BMI, number of embryos transferred, and frozen-thawed transfer were identified as independent risk factors for early spontaneous abortion (ESA) in assisted reproductive technology treatment cycles.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hongyuan Gao, Jing Ye, Hongjuan Ye, Qingqing Hong, Lihua Sun, Qiuju Chen
Summary: This study found that low serum progesterone levels on the day of frozen embryo transfer in artificial endometrium preparation cycles are associated with increased pregnancy risks, and strengthened luteal phase support may help improve pregnancy outcomes for women in artificial cycles.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Elena Labarta, Giulia Mariani, Cristina Rodriguez-Varela, Ernesto Bosch
Summary: This study analyzed the impact of individualized luteal phase support (iLPS) on live birth rates in patients with low serum progesterone levels compared to those without iLPS. The results showed that the live birth rates of patients receiving iLPS were similar to those with normal serum progesterone levels.
FERTILITY AND STERILITY
(2022)
Article
Cell Biology
Yueming Xu, Jie Zhang, Aimin Li, Ni Yang, Na Cui, Guimin Hao, Bu-Lang Gao
Summary: Elevated progesterone levels during the late follicular phase significantly impact early pregnancy outcomes and live births among IVF/ICSI patients after fresh embryo transfers. With increasing progesterone levels, clinical pregnancy rate, intrauterine pregnancy rate, and live birth rate all decrease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Jie Wang, Zhenyu Diao, Junshun Fang, Lihua Zhu, Zhipeng Xu, Fei Lin, Ningyuan Zhang, Linjun Chen
Summary: This retrospective study suggests that the day 3 embryo cell number has an influence on the clinical pregnancy and live birth rates of day 5 single blastocyst transfer in frozen embryo transfer (FET) cycles. As the day 3 embryo cell number increases, the clinical pregnancy and live birth rates also increase, especially when fair- and poor-quality blastocysts are transferred.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Lan N. Vuong, Toan D. Pham, Khanh T. Q. Le, Trung T. Ly, Ho L. Le, Diem T. N. Nguyen, Vu N. A. Ho, Vinh Q. Dang, Tuan H. Phung, Robert J. Norman, Ben W. Mol, Tuong M. Ho
Summary: Adding oral dydrogesterone to vaginal progesterone as luteal phase support in frozen embryo transfer cycles may improve pregnancy outcomes, with higher live birth rates and lower miscarriage rates. Prospective cohort studies with limited bias could provide valuable information for clinical practice as an alternative to randomized controlled trials.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Chenyang Huang, Xiaoyue Shen, Qingqing Shi, Huizhi Shan, Yuan Yan, Jingyu Liu, Na Kong
Summary: This retrospective study of 788 modified natural frozen-thawed embryo transfer (mNC-FET) cycles examined the relationship between serum progesterone (P) and luteinizing hormone (LH) levels on the human chorionic gonadotropin (hCG) trigger day and clinical pregnancy outcomes. The study found that the clinical pregnancy rate (CPR) and live birth rate (LBR) decreased significantly when LH levels were 32 IU/L or higher on the hCG day. Additionally, when P levels were equal to or higher than 1 ng/mL on the hCG day, CPR also decreased significantly.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xinhong Yang, Zhiqin Bu, Linli Hu
Summary: The study found that in the first HRT cycle, frozen-thawed blastocyst transfer on the sixth day of progesterone administration is associated with a higher live birth rate compared to transfer on the seventh day, especially among patients under 35 years old, D5 blastocyst transfer, and/or high-quality blastocyst transfer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
K. Wanggren, M. Dahlgren Granbom, S. I. Iliadis, J. Gudmundsson, A. Stavreus-Evers
Summary: The supplementation with vaginal tablets of progesterone after frozen-thawed embryo transfer in natural cycles significantly improves the number of live births.
HUMAN REPRODUCTION
(2022)
Article
Multidisciplinary Sciences
Yi-ran Du, Ke Yang, Jie Liu
Summary: The effects of serum estrogen levels on pregnancy outcomes in hormone replacement cycles were investigated. The study found that the serum estrogen levels before frozen-thawed blastocyst transfer did not affect pregnancy outcomes, and age was found to be an independent factor affecting clinical pregnancy.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Kate Devine, Matthew T. Connell, Kevin S. Richter, Christina I. Ramirez, Eric D. Levens, Alan H. DeCherney, Robert J. Stillman, Eric A. Widra
FERTILITY AND STERILITY
(2015)
Article
Obstetrics & Gynecology
Micah J. Hill, Greene Donald Royster, Mae Wu Healy, Kevin S. Richter, Gary Levy, Alan H. DeCherney, Eric D. Levens, Geeta Suthar, Eric Widra, Michael J. Levy
FERTILITY AND STERILITY
(2015)
Article
Obstetrics & Gynecology
Kevin S. Richter, Daniella K. Ginsburg, Sharon K. Shipley, Josh Lim, Michael J. Tucker, James R. Graham, Michael J. Levy
FERTILITY AND STERILITY
(2016)
Article
Obstetrics & Gynecology
Frank E. Chang, Stephanie A. Beall, Jeris M. Cox, Kevin S. Richter, Alan H. DeCherney, Michael J. Levy
FERTILITY AND STERILITY
(2016)
Article
Obstetrics & Gynecology
Joseph O. Doyle, Kevin S. Richter, Joshua Lim, Robert J. Stillman, James R. Graham, Michael J. Tucker
FERTILITY AND STERILITY
(2016)
Article
Obstetrics & Gynecology
Micah J. Hill, Mae Wu Healy, Kevin S. Richter, Eric Widra, Eric D. Levens, Alan H. DeCherney, George Patounakis, Brian W. Whitcomb
FERTILITY AND STERILITY
(2017)
Article
Obstetrics & Gynecology
Lauren A. Bishop, Kevin S. Richter, George Patounakis, Leslie Andriani, Kimberly Moon, Kate Devine
FERTILITY AND STERILITY
(2017)
Article
Obstetrics & Gynecology
Kate Devine, Kevin S. Richter, Eric A. Widra, Jeffrey L. McKeeby
FERTILITY AND STERILITY
(2018)
Article
Obstetrics & Gynecology
Micah J. Hill, Janelle C. Cooper, Gary Levy, Connie Alford, Kevin S. Richter, Alan H. DeCherney, Charles L. Katz, Eric D. Levens, Erin F. Wolff
FERTILITY AND STERILITY
(2014)
Article
Obstetrics & Gynecology
Shvetha M. Zarek, Micah J. Hill, Kevin S. Richter, Mae Wu, Alan H. DeCherney, Joseph E. Osheroff, Eric D. Levens
FERTILITY AND STERILITY
(2014)
Article
Obstetrics & Gynecology
Micah J. Hill, Mae Wu Healy, Kevin S. Richter, Toral Parikh, Kate Devine, Alan H. DeCherney, Michael Levy, Eric Widra, George Patounakis
FERTILITY AND STERILITY
(2018)
Article
Obstetrics & Gynecology
Matthew T. Connell, Kevin S. Richter, Kate Devine, Micah J. Hill, Alan H. DeCherneyl, Joseph O. Doyle, Michael J. Tucker, Michael J. Levy
REPRODUCTIVE BIOMEDICINE ONLINE
(2019)
Article
Obstetrics & Gynecology
M. Blake Evans, Natalie C. Stentz, Kevin S. Richter, Brian Schexnayder, Matt Connell, Mae W. Healy, Kate Devine, Eric Widra, Robert Stillman, Alan H. DeCherney, Micah J. Hill
OBSTETRICS AND GYNECOLOGY
(2020)
Article
Obstetrics & Gynecology
Kate Devine, Kevin S. Richter, Samad Jahandideh, Eric A. Widra, Jeffrey L. McKeeby
Summary: The study compared vaginal progesterone with intramuscular progesterone in terms of live birth rates from frozen embryo transfer (FET) and found that women receiving only vaginal progesterone had significantly lower live birth rates and higher miscarriage rates compared to those receiving intramuscular progesterone or combination treatment. Vaginal progesterone supplemented with intramuscular progesterone every third day was shown to be noninferior to daily intramuscular progesterone, offering an effective alternative regimen with fewer injections.
FERTILITY AND STERILITY
(2021)