Review
Genetics & Heredity
Veena Unnikrishnan, John Kastelic, Jacob Thundathil
Summary: In cattle, the efficiency of ICSI is hindered by failed oocyte activation post sperm injection. Research focusing on proteins like Na/K-ATPase and PLC zeta is key to improving the success rate. Enhancing the efficiency of bovine ICSI has significant implications for the cattle breeding industry.
Article
Andrology
Hong-Liang Zhang, Lian-Ming Zhao, Jia-Ming Mao, De-Feng Liu, Wen-Hao Tang, Hao-Cheng Lin, Li Zhang, Ying Lian, Kai Hong, Hui Jiang
Summary: This study aimed to compare the SRRs and clinical outcomes of patients with different causes of azoospermia who underwent micro-TESE-ICSI. Patients with orchitis had the highest and most successful SRR, along with higher rates of clinical pregnancy, implantation, and live birth. On the other hand, patients with AZFc microdeletion had a higher SRR but worse clinical outcomes.
ASIAN JOURNAL OF ANDROLOGY
(2021)
Article
Obstetrics & Gynecology
Li Zhang, Jia-ming Mao, Ming Li, Ying Lian, Sheng-li Lin, Li-xue Chen, Li-ying Yan, Jie Qiao, Ping Liu
Summary: The presence of AZFc microdeletions resulted in poorer outcomes in intracytoplasmic sperm injection (ICSI), with lower pregnancy and live birth rates compared to control groups. Patients with these deletions should be aware of their reduced chances of biological fatherhood.
FERTILITY AND STERILITY
(2021)
Review
Endocrinology & Metabolism
Yamei Xue, Xiaohong Cheng, Yuping Xiong, Kun Li
Summary: This review summarizes and discusses the mutations of nine important genes associated with fertilization failure in infertile patients. The review highlights their roles in the fertilization process and suggests these mutations as potential targets for precision treatments in reproductive medicine. Furthermore, the review provides helpful clues for genetic counseling and optimizing clinical treatments for human infertility by supplying timely information on the genetic causes of fertilization failure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Amanda Souza Setti, Daniela Paes de Almeida Ferreira Braga, Rodrigo Rosa Provenza, Assumpto Iaconelli Jr, Edson Borges Jr
Summary: The study found that the impact of sperm DNA fragmentation (SDF) on clinical outcomes of assisted reproductive technology was not significant for patients under 36 years old and between 37-40 years old. However, for mothers over 40 years old, high SDF index sperm resulted in poorer embryo quality, leading to lower implantation and pregnancy rates and increased miscarriage rates.
FERTILITY AND STERILITY
(2021)
Review
Medicine, General & Internal
Lauren Lacey, Sibte Hassan, Sebastian Franik, Mourad W. Seif, M. Ahsan Akhtar
Summary: The effects of assisted hatching (AH) on live birth rates are uncertain and may increase the risk of multiple pregnancies. Although AH may offer a slightly increased chance of achieving a clinical pregnancy, the quality of data is low, and it is uncertain whether it influences miscarriage rates.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Endocrinology & Metabolism
Hanglin Wu, Songying Zhang, Xiaona Lin, Shasha Wang, Ping Zhou
Summary: The study found that delays in progesterone supplementation until 96 hours after oocyte retrieval did not affect pregnancy outcomes. The combination of progesterone and gonadotropin-releasing hormone agonists showed significant benefits for live birth. Comparisons between active LPS treatments showed small and uncertain differences in efficacy and tolerability.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiaokun Hu, Yuliang Liu, Xiubing Zhang, Pingyin Lee, Yangxing Wen, Chenhui Ding, Canquan Zhou, Yanwen Xu
Summary: This study aimed to investigate the impact of oocyte degeneration after ICSI on cumulative live birth rate in young women; The results showed that oocyte degeneration is not an indicator for predicting the cumulative live birth rate.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yu Lan, Haiyan Zheng, Xin Fu, Tianwen Peng, Chen Liao, Jianan Liu, Min Liu, Geng An
Summary: Micro-TESE combined with ICSI-IVF can achieve favorable clinical outcomes for NOA patients. AZFc microdeletions are an important cause of poor embryological and clinical outcomes in NOA patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Takashi Shibahara, Yuu Fukasaku, Nozomi Miyazaki, Hiroaki Kawato, Hiroyuki Minoura
Summary: This study evaluated the effectiveness of expanding the indications of early rescue ICSI and found that by expanding the indications to include oocytes with <80% rate of the second polar body extrusion, more fertilized oocytes can be obtained without significantly increasing the incidence of abnormal fertilization.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Xi Zhang, Li Li, Wenhong Zhang, Yang Luo, Yuling Mao, Hongzi Du, Lei Li
Summary: This study compares the outcomes of different types of sperm retrieved using microdissection testicular sperm extraction (micro-TESE) in patients with non-obstructive azoospermia (NOA). The results indicate that artificial oocyte activation (AOA) can improve fertilization rate but does not affect embryo quality and live birth outcomes. AOA is recommended only when immotile sperm are injected.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Hye Gyeong Jeong, Seul Ki Kim, Jangmi Lee, Hye Won Youm, Byung Chul Jee
Summary: This study found that embryo quality is more closely associated with oolemma resistance during ICSI. The newly developed oolemma score helps in identifying the embryo developmental potential of each mature oocyte in ICSI cycles.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Dan-Yu Qin, Hua-Hua Jiang, Qing-Yun Yao, Wen Yao, Xiao-Qiong Yuan, Yi Wang, Tao-Ran Deng, Yao-Yao Du, Xin-Ling Ren, Na Guo, Yu-Feng Li
Summary: This study investigated the effects of rescue in vitro maturation (R-IVM) on the reproductive outcomes of women undergoing intracytoplasmic sperm injection (ICSI). The results showed that ICSI with R-IVM increased the chances of clinical pregnancy and cumulative live birth. All live births from R-IVM embryos were healthy and without malformations or complications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maryam Jenabi, Parvin Khodarahmi, Farzaneh Tafvizi, Saeed Zaker Bostanabad
Summary: This study investigated the expression levels of CXCL8 in serum, follicular fluid, and cumulus cells, and its relationship with oocyte maturation and embryo quality. The study found that CXCL8 protein and mRNA levels were higher in women with female factor infertility, and were inversely related to oocyte maturation. CXCL8 concentrations in serum and follicular fluid may be potential non-invasive biomarkers for predicting oocyte maturation outcome.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Urology & Nephrology
Solomon Hayon, Sarah Moustafa, Caitlin Boylan, Taylor P. Kohn, Mary Peavey, R. Matthew Coward
Summary: The study compared the outcomes of in vitro fertilization/intracytoplasmic sperm injection using epididymal and ejaculated sperm, finding no significant differences in fertilization rate, blastulation rate, clinical pregnancy rate, and live birth rate between the two groups.
JOURNAL OF UROLOGY
(2021)
Article
Cell Biology
Maryam Ezzati, Dariush Shanehbandi, Behzad Bahramzadeh, Kobra Hamdi, Maryam Pashaiasl
Summary: The study aimed to assess the impact of cryopreservation on fertility potential, motility, oxidative stress, DNA fragmentation, microRNAs, and apoptotic target genes in infertile men compared to fertile men. Cryopreservation led to an increase in immotile sperm, as well as elevated levels of SOD, MDA, and DNA fragmentation. It also resulted in decreased expression of P53, miR-34c, and miR-184, while enhancing expression of Caspase9 post freeze-thawing of sperm cells. Therefore, cryopreservation affects sperm fertility and motility through apoptosis-mediated mitochondrial dysfunctions.
CELL AND TISSUE BANKING
(2021)
Article
Obstetrics & Gynecology
Reza Zarezadeh, Mohammad Nouri, Kobra Hamdi, Maghsod Shaaker, Amir Mehdizadeh, Masoud Darabia
Summary: The study found that the fatty acid compositions of phospholipid and triglyceride fractions in human follicular fluid are associated with IVF cycle parameters, with some fatty acids showing negative associations with the number of mature oocytes and cleaved embryos, while others are positively associated with oocyte and embryo numbers. These associations were not independent of predictive fatty acids belonging to phospholipid fraction according to multivariate analysis.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Medicine, Research & Experimental
Hamed Hajipour, Laya Farzadi, Leila Roshangar, Zeinab Latifi, Houman Kahroba, Vahideh Shahnazi, Kobra Hamdi, Alieh Ghasemzadeh, Amir Fattahi, Mohammad Nouri
Summary: This study demonstrated the potential of uterine fluid-derived exosomes as a carrier for delivering hCG to endometrial cells, enhancing endometrial receptivity. The effect of hCG-loaded exosomes on endometrial receptivity exceeded that of hCG or exosomes alone. Furthermore, hCG-loaded exosomes showed enhanced regulation of specific gene expression compared to hCG alone.
Article
Developmental Biology
Amin Alizadegan, Hassan Dianat-Moghadam, Nasrin Shadman, Mohammad Nouri, Kobra Hamdi, Alieh Ghasemzadeh, Maryam Akbarzadeh, Parisa Sarvarian, Amir Mehdizadeh, Sanam Dolati, Mehdi Yousefi
Summary: Various biopsy and sampling methods are used for preimplantation genetic diagnosis of embryos. These invasive procedures have adverse effects on embryo development and are expensive. Therefore, non-invasive methods, such as cell free DNA (cfDNA) evaluation, have been proposed. cfDNA can be found in body fluids, such as blood, follicular fluid, amniotic fluid, spent embryo culture medium, and blastocoel fluid. This review highlights the potential of cfDNA as a supplemental tool for improving IVF and pregnancy outcomes, as well as female infertility management. However, successful application of cfDNA requires understanding of its biological properties, collection time, detection methods with high sensitivity and specificity, as well as limitations and challenges in clinical settings.
Review
Developmental Biology
Masoumeh Esmaeilivand, Ali Abedelahi, Kobra Hamdi, Laya Farzadi, Sepide Goharitaban, Amir Fattahi, Behrooz Niknafs
Summary: During the IVF cycle, embryo-secreted miRNAs can be used as potential non-invasive biomarkers for selecting the best embryos, although there are few human studies on the association between ART outcomes and miRNAs in SCM.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Reproductive Biology
Saba Nikanfar, Kobra Hamdi, Sanya Haiaty, Naser Samadi, Vahideh Shahnazi, Amir Fattahi, Mohammad Nouri
Summary: This study found that the levels of OSM and OSMR in the follicular fluid of PCOS patients were lower, possibly mediated by SOCS3, which could negatively affect oocyte maturation and fertilization rates.
REPRODUCTIVE BIOLOGY
(2022)
Review
Reproductive Biology
Rasa Khodavirdilou, Marjaneh Pournaghi, Yeganeh Rastgar Rezaei, Khadijeh Hajizadeh, Lida Khodavirdilou, Farzin Javid, Kobra Hamdi, Mahnaz Shahnazi, Mohammad Nouri, Amir Fattahi, Matthias W. Beckmann, Ralf Dittrich
Summary: The purpose of this study was to reach a consensus among contradictory studies on AMH levels throughout the menstrual cycle and determine the extent of AMH variation. The results showed that AMH levels were significantly higher in the follicular phase compared to the luteal phase, and there was no significant variation in AMH levels between the ovulatory phase, follicular phase, and luteal phase.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Biology
Amin Alizadegan, Maryam Akbarzadeh, Mohammad Sadegh Soltani-Zangbar, Roshanak Sambrani, Kobra Hamdi, Alieh Ghasemzadeh, Parvin Hakimi, Behnam Vahabzadeh, Hassan Dianat-Moghadam, Amir Mehdizadeh, Sina Mohammadinejad, Sanam Dolati, Sina Baharaghdam, Gholamreza Bayat, Mohammad Nouri, Mehdi Yousefi
Summary: This study aimed to evaluate the association between the concentration of cfDNA in the spent culture medium (SCM) and implantation rate, as well as the maternal immune system in IVF. The results showed that the concentration level of cfDNA in SCM was not associated with implantation rate, prediction of ongoing pregnancy, and maternal immune system.
BMC RESEARCH NOTES
(2022)
Review
Cell Biology
Sepide Goharitaban, Ali Abedelahi, Kobra Hamdi, Mozafar Khazaei, Masoumeh Esmaeilivand, Behrooz Niknafs
Summary: This review discusses the potential use of endometrial miRNAs as noninvasive biomarkers to predict the implantation and reproductive ability of the endometrium during in vitro fertilization (IVF) cycles. Previous studies have shown that certain miRNA levels in the endometrium are associated with implantation potential and pregnancy outcomes. This review introduces the possibility of using endometrial miRNAs as noninvasive biomarkers in assisted reproductive technology (ART) cycles to determine the optimal time for implantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Reproductive Biology
Masoumeh Esmaeilivand, Amir Fattahi, Ali Abedelahi, Kobra Hamdi, Laya Farzadi, Sepide Goharitaban, Behrooz Niknafs
Summary: The levels of miR-20a, miR-661, and ITGAV in the BF may serve as non-invasive biomarkers for evaluating embryonic health. Aneuploidy-related miRNA levels were associated with levels of genes involved in embryo implantation.
REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Soghra Hosseini Aghdam, Alyeh Ghasemzadeh, Laya Farzadi, Kobra Hamdi, Nazli Navali, Parvin Hakimi, Marayam Baradaran-Binazir, Mohammad Nouri, Amir Fattahi, Ralf Dittrich
Summary: This study investigated the effect of intrauterine administration of GH on endometrial thickness and assisted reproductive technology outcomes in patients with refractory thin endometrium. The results showed that GH treatment significantly increased endometrial thickness and improved implantation and pregnancy rates in these patients.
INTERNATIONAL JOURNAL OF FERTILITY & STERILITY
(2022)
Article
Obstetrics & Gynecology
Nazli Navali, Leila Sadeghi, Laya Farzadi, Aliyeh Ghasemzadeh, Kobra Hamdi, Parvin Hakimi, Behrooz Niknafs
Summary: This study evaluated the effectiveness of single-dose intraovarian injection of autologous platelet-rich plasma (PRP) in poor ovarian reserve. The results showed that PRP treatment significantly increased the number of oocytes, embryos, and estradiol levels in women with poor ovarian response.
INTERNATIONAL JOURNAL OF FERTILITY & STERILITY
(2022)
Article
Reproductive Biology
Laya Farzadi, Alieh Ghasemzadeh, Homayoun Sadeghi-Bazargani, Simin Taghavi, Mohammad Nouri, Kobra Hamdi, Nazli Navali, Maryam Vaez, Masumeh Dopour, Leili Abedi Gheshlaghi, Aydin Tabrizi, Sepideh Tehrani-Ghadim
Summary: This study aimed to design and validate infertility data recording tools in Iran, considering the high prevalence of infertility in the country and the lack of a system for recording data. The questionnaire was standardized and validated through a Delphi technique and evaluation by infertility specialists. The questionnaire showed good validity and reliability in recording the information of infertile couples.
INTERNATIONAL JOURNAL OF WOMENS HEALTH AND REPRODUCTION SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Soudabe Yousefi, Maryam Akbarzadeh, Jafar Soleimanirad, Kobra Hamdi, Laya Farzadi, Aalie Ghasemzadeh, Mahdi Mahdipour, Reza Rahbarghazi, Mohammad Nouri
Summary: The study aimed to evaluate the differentiation capacity of human cumulus granulosa cells (GCs) towards the oocyte-like phenotype. Results showed that a combination of leukemia inhibitory factors (LIFs) and estradiol could induce the oogenesis capacity of GCs.
ADVANCED PHARMACEUTICAL BULLETIN
(2021)
Article
Reproductive Biology
Marjan Amini, Mahnaz Ranjkesh, Saba Nikanfar, Amir Fattahi, Laya Farzadi, Kobra Hamdi
Summary: The study utilizing transvaginal ultrasound color Doppler method revealed higher resistance in uterine and sub-endometrial arteries in patients with a history of recurrent implantation failure (RIF) compared to healthy fertile women during the follicular phase. Assessing uterine perfusion indices during this phase could serve as a non-invasive method for evaluating patients with RIF.
INTERNATIONAL JOURNAL OF WOMENS HEALTH AND REPRODUCTION SCIENCES
(2021)