Article
Obstetrics & Gynecology
Reitan Ribeiro, Maria Cristina Anselmi, Gunther Alex Schneider, Jose Pio Rodrigues Furtado, Mohamed Gaber Mohamed Abau Shwareb, Jose Clemente Linhares
Summary: This is the first reported case of a live birth after uterine transposition, pelvic radiotherapy, and subsequent uterine repositioning. A 28-year-old nulligravid woman underwent uterine transposition before receiving pelvic and thoracic radiation therapy. After successful radiation treatment, her uterus was reimplanted in the pelvis. The patient became pregnant and delivered a healthy baby after 36 weeks of gestation.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Ellen Kupka, Susanne Hesselman, Roxanne Hastie, Riccardo Lomartire, Anna Karin Wikstrom, Lina Bergman
Summary: This study aimed to investigate the association between low-dose aspirin use and preterm birth among women with a previous preterm birth. A Swedish register-based cohort study found that low-dose aspirin use was associated with a reduced risk of preterm birth, particularly in spontaneous preterm births.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Laura Emilie Vexo, Sacha Stormlund, Selma Kloeve Landersoe, Henrik Lovendahl Jorgensen, Peter Humaidan, Christina Bergh, Anne Lis Mikkelsen Englund, Anna Klajnbard, Jeanette Wulff Bogstad, Nina la Cour Freiesleben, Anne Zedeler, Lisbeth Praetorius, Anders Nyboe Andersen, Kristine Lossl, Anja Pinborg, Henriette Svarre Nielsen
Summary: Low-grade inflammation, detected by CRP, is associated with the outcome of IVF, including blastocyst quality and pregnancy outcome. Higher baseline CRP concentrations are negatively associated with live birth rate and are associated with pregnancy loss. However, there is no association between CRP concentrations and the number of good-quality blastocysts. More studies are needed to investigate the impact of low-grade inflammation.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Maya Sharon-Weiner, Hadar Gluska, Sivan Farladansky-Gershenabel, Hanoch Schreiber, Amir Wiser, Adrian Shulman, Anat Hershko-Klement
Summary: The study found that IVF should not be postponed following a pregnancy loss, as shorter intervals were associated with greater likelihood of live birth. Patients after biochemical or spontaneous miscarriage typically had shorter intervals to the next cycle, while those after medical or surgical miscarriages had longer intervals.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Oncology
Kimia Sorouri, Tal Sella, Shoshana M. Rosenberg, Maggie Loucks, Gregory Kirkner, Craig Snow, Kathryn J. Ruddy, Shari I. Gelber, Rulla M. Tamimi, Jeffrey M. Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ellen Warner, Ann H. Partridge
Summary: This study investigated the postcancer conception and pregnancy experience of young BC survivors and found that most of them conceived naturally without negative impact from the history of BC. However, a higher rate of hypertensive disorders of pregnancy was observed, requiring further investigation.
Article
Obstetrics & Gynecology
Rebecca Horgan, Yara Hage Diab, Jerri Waller, Alfred Abuhamad, George Saade
Summary: The dosage and timing of aspirin initiation are crucial for reducing the risk of preeclampsia. Initiating a dosage of >100 mg of aspirin daily before 16 weeks' gestation seems to be the most effective approach. Randomized control trials are needed to evaluate the safety and efficacy of different aspirin dosages available in the United States.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Hematology
Eva N. Hamulyak, Luuk J. J. Scheres, Mariette Goddijn, Saskia Middeldorp
Summary: Aspirin and heparin are commonly used to reduce the risk of recurrent pregnancy loss in women with antiphospholipid syndrome. Evidence suggests that heparin plus aspirin may improve live birth rates in these women, but the certainty of this evidence is low.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Obstetrics & Gynecology
Maeliss Peigne, Valerie Bernard, Laura Dijols, Helene Creux, Geoffroy Robin, Claude Hocke, Michael Grynberg, Didier Dewailly, Charlotte Sonigo
Summary: This study conducted a systematic review and meta-analysis to evaluate whether serum anti-Mullerian hormone (AMH) level can predict the cumulative live birth (CLB) rate after assisted reproductive technology (ART) or in women trying to conceive naturally. The results showed a positive relation between serum AMH level and CLB after IVF/ICSI, but there is a lack of data for IUI or natural conception without ART.
HUMAN REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Jacqueline E. Rudolph, Kwangho Kim, Edward H. Kennedy, Ashley I. Naimi
Summary: This study aims to assess the incremental effects of time-varying exposure, using data from an experiment on the impact of aspirin on pregnancy outcomes. The results suggest that increasing women's probability of taking aspirin has little impact on pregnancy rates.
Article
Obstetrics & Gynecology
Si Sun, HongYang Qian, Congcong Li, Qiaohong Wang, Aimin Zhao
Summary: This study retrospectively investigated the safety of low dose aspirin (LDA) during pregnancy. The results showed that the use of aspirin did not increase the risk of fetal congenital anomalies. Additionally, a previous history of fetal abnormalities was found to be an independent risk factor for congenital anomalies.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
S. L. Mumford, K. S. Flannagan, J. G. Radoc, L. A. Sjaarda, J. R. Zolton, T. D. Metz, T. C. Plowden, N. J. Perkins, E. A. De Vilbiss, V. C. Andriessen, A. C. Purdue-Smithe, K. Kim, S. F. Yisahak, J. R. Freeman, Z. Alkhalaf, R. M. Silver, E. F. Schisterman
Summary: The study found that preconception cannabis use was associated with reduced fecundability among women with a history of pregnancy loss, despite an increased frequency of intercourse.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Xiaoxin Zhang, Feng Guo, Qiaohong Wang, Wenxin Bai, Aimin Zhao
Summary: The study found that patients with URBPL had higher resistance of endometrial perfusion compared to normal group, with predictive values. After treatment with LDA, there was a significant improvement in endometrial blood perfusion in patients with URBPL.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Review
Obstetrics & Gynecology
Jyotsna Pundir, Chiara Achilli, Priya Bhide, Luca Sabatini, Richard S. Legro, Luk Rombauts, Helena Teede, Arri Coomarasamy, Javier Zamora, Shakila Thangaratinam
Summary: There is no evidence that letrozole increases the risk of congenital foetal malformation or pregnancy loss compared with clomiphene, natural conception or other fertility agents, to warrant warning against its use. Given its therapeutic benefits and lack of evidence of harm to the foetus, clinicians should consider letrozole as first-line agent for ovulation induction.
HUMAN REPRODUCTION UPDATE
(2021)
Review
Obstetrics & Gynecology
Eleanor M. F. Richards, Veronica Giorgione, Oliver Stevens, Basky Thilaganathan
Summary: This systematic review and meta-analysis aimed to investigate the potential benefits of low-dose aspirin use during pregnancy in women with chronic hypertension. The analysis found that low-dose aspirin did not significantly reduce the odds of superimposed preeclampsia or poor perinatal outcomes. However, it did show a significant reduction in preterm birth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Qiongjie Zhou, Xingzhong Zhao, Jinghui Xu, Yu Xiong, Jon F. R. Barrett, Xing-Ming Zhao, Xiaotian Li
Summary: This retrospective study aimed to describe the frequency of preeclampsia and aspirin use in real-world practice among women with twin pregnancies. The results showed that the use of low-dose aspirin was associated with a higher incidence of preeclampsia, possibly due to poor compliance with the medication. Further randomized controlled trials or prospective cohort studies are needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jennifer W. Bea, Zhao Chen, Robert M. Blew, Jennifer Skye Nicholas, Shawna Follis, Victoria L. Bland, Ting-Yuan David Cheng, Heather M. Ochs-Balcom, Jean Wactawski-Wende, Hailey R. Banack, Marian L. Neuhouser, Deepika Laddu, Marcia L. Stefanick, Jane A. Cauley, Bette Caan, Meryl S. LeBoff, Rowan T. Chlebowski, Andrew O. Odegaard
Summary: This study validates the feasibility of using new software on historical DXA scans to estimate VAT and SAT, which are well-correlated with criterion MRI among postmenopausal women.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Article
Geriatrics & Gerontology
Joseph S. Goveas, Roberta M. Ray, Nancy F. Woods, JoAnn E. Manson, Candyce H. Kroenke, Yvonne L. Michael, Aladdin H. Shadyab, Jaymie R. Meliker, Jiu-Chiuan Chen, Lisa Johnson, Charles Mouton, Nazmus Saquib, Julie Weitlauf, Jean Wactawski-Wende, Michelle Naughton, Sally Shumaker, Garnet L. Anderson
Summary: The study found that loneliness increased in older women during the pandemic and was associated with higher levels of stress, depression, and anxiety symptoms. The results suggest opportunities for interventions targeting lifestyle behaviors, well-being, disrupted social connections, and specific medical and mental health histories to reduce loneliness and improve mental health.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Jonathan Fix, Macarius M. Donneyong, Stephen R. Rapp, Maryam Sattari, Beverly M. Snively, Jean Wactawski-Wende, Emily W. Gower
Summary: Predictors associated with pneumococcal and seasonal influenza vaccination among older women include race, health insurance, and residential area. The study emphasizes the need to improve access, education, and provider recommendations for vaccination.
PUBLIC HEALTH REPORTS
(2023)
Article
Geriatrics & Gerontology
Bonnie C. Sachs, Sarah A. Gaussoin, Gretchen A. Brenes, Ramon Casanova, Rowan T. Chlebowski, Jiu-Chiuan Chen, Juhua Luo, Stephen R. Rapp, Aladdin H. Shadyab, Sally Shumaker, Jean Wactawski-Wende, Gretchen L. Wells, Kathleen M. Hayden
Summary: The relationship between optimism and cognitive functioning is not fully understood. This study found that less pessimism was associated with a lower risk of mild cognitive impairment (MCI) and dementia, while more optimism did not have a significant relationship with these conditions.
AGING & MENTAL HEALTH
(2023)
Article
Oncology
Tarah J. Ballinger, Zora Djuric, Sagar Sardesai, Kathleen M. Hovey, Chris A. Andrews, Theodore M. Brasky, Jian Ting Zhang, Thomas E. Rohan, Nazmus Saquib, Aladdin H. Shadyab, Michael Simon, Jean Wactawski-Wende, Robert Wallace, Ikuko Kato
Summary: This study found that the use of PPI was inversely associated with the risk of colorectal cancer, while the use of H2RA showed no such association. This relationship is consistent with the preclinical data showing the preventive effect of FASN inhibition on colon cancer.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Biochemical Research Methods
Lu Li, Jiho Sohn, Robert J. Genco, Jean Wactawski-Wende, Steve Goodison, Patricia I. Diaz, Yijun Sun
Summary: By modeling the relationship between microbial communities and chronic disease development using cross-sectional sample data, valuable insights into the role of the microbiome in the pathogenesis of chronic diseases can be obtained.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexi Vasbinder, Richard K. Cheng, Susan R. Heckbert, Hilaire Thompson, Oleg Zaslavksy, Rowan T. Chlebowski, Aladdin H. Shadyab, Lisa Johnson, Jean Wactawski-Wende, Gretchen Wells, Rachel Yung, Lisa Warsinger Martin, Electra D. Paskett, Kerryn Reding
Summary: This study aimed to investigate the associations between biomarkers and long-term radiation-induced cardiovascular disease (RICVD) in breast cancer survivors. The results showed that a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting that oxidative DNA damage may be a potential pathway for RICVD.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Sonia M. Grandi, Stefanie N. Hinkle, Sunni L. Mumford, Lindsey A. Sjaarda, Katherine L. Grantz, Pauline Mendola, James L. Mills, Anna Z. Pollack, Edwina Yeung, Cuilin Zhang, Enrique F. Schisterman
Summary: This study examined whether giving birth to male infants increases the risk of maternal mortality. The results showed that women who give birth to male infants do not have an increased risk of all-cause and cause-specific mortality, suggesting that giving birth to male infants may not influence the long-term health of women.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Summary: Preterm birth is associated with increased risk of developing type 2 diabetes at an earlier age, but not with overall risk of incident type 2 diabetes. The association between preterm birth and type 2 diabetes may exist during early years but wane over time.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Medicine, General & Internal
Diddier Prada, Carolyn J. Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen, Gary Miller, Iuliana Ionita-Laza, Eric A. Whitsel, Andrea A. Baccarelli
Summary: Osteoporosis has a major impact on postmenopausal women, and it is influenced by environmental exposures. This study found that criteria air pollutants, such as PM10, NO, NO2, and SO2, were negatively associated with bone mineral density in postmenopausal women. Nitrogen oxides exposure was identified as the leading contributor to bone loss in this population.
Article
Oncology
Ana Babic, Qiao-Li Wang, Alice A. Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K. Tabung, Aladdin H. Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft, Howard D. Sesso, Julie E. Buring, Edward L. Giovannucci, JoAnn E. Manson, Meir J. Stampfer, Kimmie Ng, Charles S. Fuchs, Brian M. Wolpin
Summary: The study found that high levels of adiponectin in the prediagnostic period were associated with shorter survival among women with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR were associated with patient survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Clinical Neurology
Galit Dunietz, Kerby Shedden, Kara Michels, Ronald Chervin, Xiru Lyu, Joshua Freeman, Ana Baylin, Louise O'Brien, Jean Wactawski-Wende, Enrique Schisterman, Sunni Mumford