Article
Endocrinology & Metabolism
Keerthana Rajasekaran, Neena Malhotra, Reeta Mahey, Rajesh Khadgawat, Mani Kalaivani
Summary: The study compared the effects of myoinositol and metformin in reducing the risk of OHSS and improving ART outcomes in PCOS women undergoing IVF, finding that myoinositol is equally beneficial as metformin in reducing the risk of OHSS and has better ART outcomes in some aspects.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Shan Liu, Ya-Su Lv, Shuo Han, Minghui Liu, Shuai Ma, Haiying Ren, Yuan Li
Summary: This study aims to compare the LH-based flexible GnRH antagonist protocol and traditional flexible GnRH antagonist protocol for PCOS patients to determine if there is a significant difference in cumulative ongoing pregnancy rates. The primary efficacy endpoint is the cumulative ongoing pregnancy rate per cycle.
Article
Obstetrics & Gynecology
Ginevra Mills, Michael H. Dahan
Summary: In the study, the use of GnRH antagonists in GnRH agonist cycles was found to reduce the risk of developing moderate and severe OHSS by promoting luteolysis and downregulating VEGF production and receptor response, thereby decreasing vascular permeability.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Medicine, General & Internal
Delbar Daneshjou, Shahrzad Zadeh Modarres, Malek Soleimani Mehranjani, Seyed Mohammad Ali Shariat Zadeh
Summary: In this study, it was found that sitagliptin was more effective than metformin in improving the maturation of oocytes and the quality of embryos in PCOS patients undergoing ICSI. The treated groups showed a significant reduction in serum insulin and total testosterone levels, along with an increase in the number of mature and normal MII oocytes. The sitagliptin group also had a significant increase in the number of grade I embryos compared to the placebo group.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Sally Kadoura, Marwan Alhalabi, Abdul Hakim Nattouf
Summary: PCOS exaggerates ovarian response to stimulation, while FF PlGF levels may serve as a marker of ovarian response. However, PCOS does not have a detrimental impact on oocytes morphology or competence.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Medicine, General & Internal
Sally Kadoura, Marwan Alhalabi, Abdul Hakim Nattouf
Summary: This study compared IVF/ICSI outcomes and correlations with follicular fluid PlGF levels between PCOS and normal ovulatory women undergoing different hyperstimulation protocols. Although PCOS exaggerated ovarian response to stimulation, it did not negatively impact oocyte morphology or competence. Additionally, FF PlGF levels may serve as a marker of ovarian response rather than a predictor of pregnancy achievement.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Genetics & Heredity
Veronique Bellemare, Keren Rotshenker-Olshinka, Laura Nicholls, Alyson Digby, Amrita Pooni, Einav Kadour-Peero, Weon-Young Son, Michael H. Dahan
Summary: The study aimed to assess the potential of oocytes from hyperresponding polycystic ovary syndrome (PCOS) patients to develop into blastocysts. The findings showed that there were no significant differences between PCOS patients and high-responder controls in terms of oocyte collection, fertilization, blastulation rates, and pregnancy rates.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Endocrinology & Metabolism
Jianing Xu, Cuilian Zhang, Shuna Wang, Shaodi Zhang
Summary: This study investigated the impact of progesterone concentration on clinical outcomes in blastocyst transfer cycles with an antagonist protocol. It found a significant association between progesterone concentration and clinical pregnancy rate, particularly in blastocyst transfer. The relationship between progesterone concentration and ongoing pregnancy rate was insignificant. The study also identified a curvilinear relationship between progesterone concentration and pregnancy outcomes, with the optimal threshold being 0.80 ng/mL.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Jamie Merkison, Carrie Malcom, Alan Decherney
Summary: Stem cell transplantation has shown significant improvement and potentially a cure in patients with various hematologic disorders and genetic immune deficiencies. However, it often leads to primary ovarian insufficiency, highlighting the importance of optimizing fertility preservation protocols.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Liting Zhang, He Cai, Xitong Liu, Yao Xiong, Xiaoling Liang, Juanzi Shi
Summary: This study compared the pregnancy outcomes of infertile women with adenomyosis under different treatment protocols and found that there were no significant differences in clinical pregnancy rate, live birth rate, and cumulative live birth rate between the GnRH antagonist protocol with freeze-all strategy group and the long-acting GnRH agonist protocol group.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Endocrinology & Metabolism
Yifan Chu, Luyao Wang, Jiaxin Xie, Shulin Yang, Si Liu, Dan Hu, Jing Yue
Summary: This study aims to evaluate the impact of growth hormone (GH) on IVF/ICSI outcomes and endometrial receptivity in patients undergoing GnRH-ant protocol with fresh embryo transfer. It will also explore the possible mechanism of GH in improving pregnancy outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yubin Li, Yuwei Duan, Xi Yuan, Bing Cai, Yanwen Xu, Yuan Yuan
Summary: A novel nomogram has been developed to accurately predict the gonadotropin starting dose in GnRH antagonist protocol, with a high accuracy rate. The multivariate regression model based on AMH level, AFC, and BMI can explain 59% of the variability of ovarian sensitivity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mauro S. B. Silva, Paolo Giacobini
Summary: Research on the physiological actions of anti-Mullerian hormone (AMH) has expanded beyond its classical role in male sexual differentiation to include regulation of ovarian function, clinical use in reproductive health, and its potential as a biomarker for polycystic ovary syndrome (PCOS). Recent studies have shown that AMH can have effects throughout the Hypothalamic-Pituitary-Gonadal (HPG) axis, providing new insights into reproductive disorders and potentially contributing to the pathophysiology of diseases such as PCOS.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, General & Internal
Yunliao Luo, Huajuan Shen, Hongjing Li, Zongjian Tan, Chaojun Chen, Weiming Chen, Jun He
Summary: This article reports a rare case of ovarian hyperstimulation syndrome (OHSS) combined with ruptured corpus luteum during twin pregnancy. Through dynamic ultrasound monitoring and observation of vital signs, surgical exploration was avoided and the twin pregnancy was successfully preserved.
Article
Medicine, General & Internal
Shaomi Zhu, Zhexi Lv, Linjiang Song, Qinxiu Zhang, Yiyue Fan, Junjun Li
Summary: This study conducted a systematic review and meta-analysis to examine the impact of estradiol pretreatment on reproductive outcomes and ovary stimulation characteristics in IVF/ICSI treatment with GnRH antagonist protocol. The results showed that luteal estradiol pretreatment did not affect reproductive outcomes in patients with normal ovarian response in GnRH antagonist protocol.