Article
Biochemistry & Molecular Biology
Kazuma Iida, Kensuke Suga, Kotaro Suzuki, Shunjiro Kurihara, Yoko Yabe, Takahiro Kageyama, Kazuyuki Meguro, Shigeru Tanaka, Arifumi Iwata, Akira Suto, Hiroshi Nakajima
Summary: The study found that Achaete-scute complex homolog 2 (Ascl2) is highly and preferentially expressed in CD25+ and CD25- T follicular regulatory (Tfr) cells. The absence of Ascl2 impairs the differentiation from CD25+ Tfr cells to CD25- Tfr cells. Additionally, forced expression of Ascl2 in regulatory T (Treg) cells downregulates CD25 expression and suppresses IL-2-induced phosphorylation of STAT5, which inhibits the development of CD25- Tfr cells. These findings suggest that Ascl2 plays a vital role in Tfr cell development by downregulating CD25 expression in a Bach2-independent mechanism.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Ilse Wieland, Ina Schanze, Ina Marianti Felgendreher, Winfried Barthlen, Silke Vogelgesang, Klaus Mohnike, Martin Zenker
Summary: This study found that paternal UPD on the short arm of chromosome 11 is the major second genetic event specifically within focal lesions of CHI, leading to LOH and monoallelic expression of the mutated ABCC8/KCNJ11 alleles. Additionally, upregulation of growth promoting gene ASCL2 and downregulation of growth suppressing genes CDKN1C and H19 were observed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Kenneth P. Seastedt, George A. Alyateem, Karthik Pittala, Seth M. Steinberg, David S. Schrump, Lynnette K. Nieman, Chuong D. Hoang
Summary: This study analyzed the outcomes of lung neuroendocrine tumors associated with Cushing syndrome and found that these tumors have higher nodal metastasis, higher recurrence rates, and shorter disease-free survival compared to quiescent bronchopulmonary carcinoid tumors. However, many patients still experienced favorable outcomes, indicating that a lung-sparing approach could be sufficient. These results suggest that the hormone physiology may play a more important role than the carcinoid biologic factors in determining prognosis.
Review
Oncology
Claire K. Mulvey
Summary: Precision medicine is a new approach to diagnosing and treating cancer that considers individual patient differences. The precision medicine treatment options for lung neuroendocrine tumors have been lagging behind other cancers, but recent advances in understanding the molecular basis of these tumors and increasing clinical trials offer potential for personalized treatment.
Review
Oncology
Mateusz Bilski, Paulina Mertowska, Sebastian Mertowski, Marcin Sawicki, Anna Hymos, Paulina Niedzwiedzka-Rystwej, Ewelina Grywalska
Summary: Neuroendocrine neoplasms (NETs) are rare tumors, mostly occurring in the digestive system and less commonly in the respiratory system. Treatment of NETs requires a multidisciplinary team, including oncology surgeons, clinical oncologists, and radiation oncologists. Radiotherapy is commonly used in the treatment of lung NETs, but there is a lack of recommendations for radiotherapy. This article reviews the current knowledge on the use of radiotherapy in the treatment of lung NETs and provides clinical case descriptions to help radiation oncologists make personalized treatment decisions.
Article
Endocrinology & Metabolism
Elisa Lenotti, Andrea Alberti, Francesca Spada, Vito Amoroso, Patrick Maisonneuve, Salvatore Grisanti, Alice Baggi, Susanna Bianchi, Nicola Fazio, Alfredo Berruti
Summary: This study retrospectively evaluated the outcomes of patients with metastatic lung NET treated with first line SSAs in two Italian reference Institutions from 2014 to 2019. The results showed that the long PFS and OS obtained suggest that SSAs could be effective as a first line approach in managing patients with progressive, metastatic pulmonary NET.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Yanan Wang, Fangfei Qian, Ya Chen, Zhengyu Yang, Minjuan Hu, Jun Lu, Yanwei Zhang, Wei Zhang, Lei Cheng, Baohui Han
Summary: This study compared the clinical features, mutation status of driver genes, and prognosis between combined LCNEC and combined SCLC, revealing significant differences and a more favorable outcome for patients with combined LCNEC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Na Zhang, Jie Zhang, Zhihong Liu, Tushuai Li
Summary: This study utilized ChIP-seq data to analyze the gene transcription regulation network of ASCL1 in GBM and identified EGFR, SPTAN1, and CTNN1B as potential downstream genes in GBM development.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Makoto Yamamoto, Renma Ito, Akihiko Tsujibata, Hiroko Morita, Taro Yoneda, Yutaka Matano, Toshinori Higashikata
Summary: A 76-year-old woman with refractory diarrhea was found to have a 24x22 mm mass in the left upper lobe of lung and multiple masses in the liver. Elevated urine 5-hydroxy indol acetic acid confirmed the presence of carcinoid syndrome, which was caused by large-cell neuroendocrine carcinoma of the lung. The patient died 50 days after admission despite chemotherapy.
Review
Medicine, Research & Experimental
Cornel Savu, Alexandru Melinte, Camelia Diaconu, Ovidiu Stiru, Florentina Gherghiceanu, Stefan Dragos Octavian Tudorica, Oana Clementina Dumitrascu, Angelica Bratu, Irina Balescu, Nicolae Bacalbasa
Summary: Neuroendocrine tumors (NETs) are a group of heterogeneous malignancies that often appear in the thorax, especially in the tracheobronchial tree and thymus. The focus is on molecular diagnosis data and differentiating lung neuroendocrine tumors (LNETs). Understanding histological evaluation, genetic aberrations, prognosis, and therapeutic options is crucial for efficient management of these rare tumors.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Oncology
Jace P. Landry, Brianne A. Voros, Robert A. Ramirez, J. Philip Boudreaux, Eugene A. Woltering, Ramcharan Thiagarajan
Summary: The study evaluated the metastatic potential of appendiceal neuroendocrine tumors (ANETs) < 2 cm diameter and found that smaller tumors had metastatic capability. Factors like patient age, tumor characteristics were associated with metastatic diseases. Appendectomy alone was deemed sufficient for most ANETs patients, regardless of tumor size.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Mathilde Prieto, Guillaume Chassagnon, Audrey Lupo, Marie-Christine Charpentier, Eglantine Cabanne, Lionel Groussin, Marie Wislez, Marco Alifano, Ludovic Fournel
Summary: DIPNECH-associated carcinoid tumors exhibit negative pathological features and may require specialized perioperative management. Patients with DIPNECH are older, more frequently female, and more likely to have comorbidities such as diabetes or hypertension. Atypical histology and mediastinal lymph nodes involvement are independent factors of pN2 invasion in DIPNECH patients.
Article
Medicine, General & Internal
Hyung Kyu Park, Ghee Young Kwon
Summary: This study compared the metastatic patterns of neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), and non-neuroendocrine neoplasms (non-NENs), and found significant differences between NETs/NECs and non-NENs. The key factor causing these differences may be associated with the multigene program of neuroendocrine differentiation.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Oncology
Jin-Dong Li, Cheng-Yan Jin, Yan Zhang, Hang Guo, Guang-Lei Zhang, Chun-Guang Wang
Summary: This case report describes a patient with lung cancer who experienced histopathological transformation from squamous-cell carcinoma to large cell neuroendocrine carcinoma with a small fraction of small cell carcinoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Thomas Yang Sun, Andrew Hendifar, Sukhmani K. Padda
Summary: This review highlights the role of molecular profiling in the prognosis and treatment of lung neuroendocrine tumors (NETs). Currently, there are no identified molecular prognostic factors for lung NETs, and no routinely used molecular markers to guide patient management. Lung NETs have low tumor mutation burden and low PD-L1 expression, distinguishing them from non-small cell lung cancer and small cell lung cancer. Everolimus, an mTOR inhibitor, is the only FDA approved therapy for unresectable lung NETs, but its predictive value for treatment response in the presence of molecular alterations is unknown.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Eun Young Kim, Yi Zhang, Bo Ye, Ana Maria Segura, Ilimbek Beketaev, Yutao Xi, Wei Yu, Jiang Chang, Faqian Li, Jun Wang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2015)
Article
Cardiac & Cardiovascular Systems
Bo Ye, Ning Hou, Lu Xiao, Yifan Xu, James Boyer, Haodong Xu, Faqian Li
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Bo Ye, Ning Hou, Lu Xiao, Yifan Xu, Haodong Xu, Faqian Li
CARDIOVASCULAR PATHOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Ning Hou, Bo Ye, Xiang Li, Kenneth B. Margulies, Haodong Xu, Xuejun Wang, Faqian Li
CIRCULATION-HEART FAILURE
(2016)
Article
Biochemistry & Molecular Biology
Ning Wang, Rong Huo, Benzhi Cai, Yan Lu, Bo Ye, Xiang Li, Faqian Li, Haodong Xu
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Pathology
Ning Hou, Ying Wen, Xun Yuan, Haodong Xu, Xuejun Wang, Faqian Li, Bo Ye
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2017)
Article
Medicine, Research & Experimental
Bo Ye, Liwen Li, Haodong Xu, Yiping Chen, Faqian Li
LABORATORY INVESTIGATION
(2019)
Article
Cardiac & Cardiovascular Systems
Rong Huo, Chaowei Hu, Limei Zhao, Lihua Sun, Ning Wang, Yan Lu, Bo Ye, Arjun Deb, Faqian Li, Haodong Xu
Article
Cardiac & Cardiovascular Systems
Penglong Wu, Yifan Li, Mingqi Cai, Bo Ye, Bingchuan Geng, Faqian Li, Hua Zhu, Jinbao Liu, Xuejun Wang
Summary: This study found that UCHL1 plays a crucial protective role in cardiomyocytes by promoting autophagy and reducing cardiac dysfunction after myocardial infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Gabrielle Nelson, Bo Ye, Morgan Schock, Daniel L. Lustgarten, Elisabeth K. Mayhew, Bradley M. Palmer, Markus Meyer
Summary: Increased heart rate leads to higher intracellular Na+ levels and delayed regulation of NKA activity. NKA plays an adaptive role in maintaining membrane potential and cellular Ca2+ homeostasis by preserving Na+ and K+ gradients.
PHYSIOLOGICAL REPORTS
(2022)
Meeting Abstract
Pathology
Tracy A. Stein, Mohamed El Hag, Bo Ye, Prachi Raut, Guang-Qian Xiao, Haodong Xu, Mahmoud Khalifa, Faqian Li
Meeting Abstract
Pathology
Mohamed El Hag, Tracy A. Stein, Bo Ye, Prachi Raut, Haodong Xu, Mahmoud Khalifa, Faqian Li
Meeting Abstract
Medicine, Research & Experimental
Tracy A. Stein, Mohamed El Hag, Bo Ye, Prachi Raut, Guang-Qian Xiao, Haodong Xu, Mahmoud Khalifa, Faqian Li
LABORATORY INVESTIGATION
(2016)
Meeting Abstract
Medicine, Research & Experimental
Mohamed El Hag, Tracy A. Stein, Bo Ye, Prachi Raut, Haodong Xu, Mahmoud Khalifa, Faqian Li
LABORATORY INVESTIGATION
(2016)