Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients

Truncated prelamin A expression in HGPS-like patients: a transcriptional study

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Antagonistic functions of LMNA isoforms in energy expenditure and lifespan

(2014) I. C. Lopez-Mejia et al.   EMBO REPORTS

Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK pathways

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Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

Antisense Oligonucleotide Induction of Progerin in Human Myogenic Cells

(2014) Yue-Bei Luo et al.   PLoS One

Targeting SR Proteins Improves SMN Expression in Spinal Muscular Atrophy Cells

(2014) Claribel D. Wee et al.   PLoS One

Genomics of alternative splicing: evolution, development and pathophysiology

(2013) Eric R. Gamazon et al.   HUMAN GENETICS

Hutchinson–Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates

(2013) Elizabeth A. Booth-Gauthier et al.   Integrative Biology

Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment

(2013) N. J. Ullrich et al.   NEUROLOGY

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome

(2012) L. B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders

(2012) Siwon Choi et al.   Nucleus

Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A

(2011) Fuki M. Hisama et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A conserved splicing mechanism of the LMNA gene controls premature aging

(2011) Isabel C. Lopez-Mejia et al.   HUMAN MOLECULAR GENETICS

A Homozygous Mutation of Prelamin-A Preventing Its Farnesylation and Maturation Leads to a Severe Lipodystrophic Phenotype: New Insights into the Pathogenicity of Nonfarnesylated Prelamin-A

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Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

(2011) F. G. Osorio et al.   Science Translational Medicine

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action

(2010) Jamal Tazi et al.   FEBS Journal

Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes

(2010) Roger Lee et al.   HUMAN MOLECULAR GENETICS

An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria

(2010) B. S. J. Davies et al.   HUMAN MOLECULAR GENETICS

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration

(2009) P-C Chang et al.   GENE THERAPY

Activating the synthesis of progerin, the mutant prelamin A in Hutchinson–Gilford progeria syndrome, with antisense oligonucleotides

(2009) Loren G. Fong et al.   HUMAN MOLECULAR GENETICS

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson–Gilford progeria syndrome mutation

(2007) S YANG   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS