MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform

The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

(2015) Qing Fang et al.   eLife

The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells

(2014) E. Pepermans et al.   EMBO Molecular Medicine

Magnesium Impacts Myosin V Motor Activity by Altering Key Conformational Changes in the Mechanochemical Cycle

(2013) Darshan V. Trivedi et al.   BIOCHEMISTRY

Myosin 3A Kinase Activity Is Regulated by Phosphorylation of the Kinase Domain Activation Loop

(2013) Omar A. Quintero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise

(2013) D. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin IIIB Uses an Actin-Binding Motif in Its Espin-1 Cargo to Reach the Tips of Actin Protrusions

(2012) Raymond C. Merritt et al.   CURRENT BIOLOGY

Autosomal recessive nonsyndromic deafness genes: a review

(2012) Duygu Duman   Frontiers in Bioscience-Landmark

Temperature dependent measurements reveal similarities between muscle and non-muscle myosin motility

(2012) Christopher M. Yengo et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Etiologic Diagnosis of Nonsyndromic Genetic Hearing Loss in Adult vs Pediatric Populations

(2012) Peter J. King et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Challenges in Whole Exome Sequencing: An Example from Hereditary Deafness

(2012) Asli Sirmaci et al.   PLoS One

Regulation of Stereocilia Length by Myosin XVa and Whirlin Depends on the Actin-Regulatory Protein Eps8

(2011) Uri Manor et al.   CURRENT BIOLOGY

Deafness in the genomics era

(2011) A. Eliot Shearer et al.   HEARING RESEARCH

Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

(2011) M. Grati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome

(2011) S. B. Pierce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the DBP-Deficiency Protein HSD17B4 Cause Ovarian Dysgenesis, Hearing Loss, and Ataxia of Perrault Syndrome

(2010) Sarah B. Pierce et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genomic Duplication and Overexpression of TJP2/ZO-2 Leads to Altered Expression of Apoptosis Genes in Progressive Nonsyndromic Hearing Loss DFNA51

(2010) Tom Walsh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Intermolecular Autophosphorylation Regulates Myosin IIIa Activity and Localization in Parallel Actin Bundles

(2010) Omar A. Quintero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA

(2010) Vanessa L. Walsh et al.   MAMMALIAN GENOME

Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments

(2009) Felipe T. Salles et al.   NATURE CELL BIOLOGY

The Kinase Domain Alters the Kinetic Properties of the Myosin IIIA Motor†

(2008) Andréa C. Dosé et al.   BIOCHEMISTRY