A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease

(2015) Yolandi Espach et al.   CARDIOVASCULAR DRUGS AND THERAPY

A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease

(2015) Rosanna Beraldi et al.   HUMAN MOLECULAR GENETICS

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

ATM functions at the peroxisome to induce pexophagy in response to ROS

(2015) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

DNA Double-strand Break Repair in a Cellular Context

(2014) A. Shibata et al.   CLINICAL ONCOLOGY

ATM: Expanding roles as a chief guardian of genome stability

(2014) Yosef Shiloh   EXPERIMENTAL CELL RESEARCH

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Intra-Erythrocyte Infusion of Dexamethasone Reduces Neurological Symptoms in Ataxia Teleangiectasia Patients: Results of a Phase 2 Trial

(2014) Luciana Chessa et al.   Orphanet Journal of Rare Diseases

The Interaction of the Atm Genotype with Inflammation and Oxidative Stress

(2014) Yan Yang et al.   PLoS One

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

(2014) Dora Brites et al.   Frontiers in Cellular Neuroscience

Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury

(2013) David P. Stirling et al.   BRAIN

The Innate Immune Response Transcription Factor Relish Is Necessary for Neurodegeneration in aDrosophilaModel of Ataxia-Telangiectasia

(2013) Andrew J. Petersen et al.   GENETICS

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

The mammalian PYHIN gene family: Phylogeny, evolution and expression

(2012) Jasmyn A Cridland et al.   BMC EVOLUTIONARY BIOLOGY

DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo

(2012) Sylvia Takacova et al.   CANCER CELL

Betamethasone therapy in ataxia telangiectasia: unraveling the rationale of this serendipitous observation on the basis of the pathogenesis

(2012) G. Giardino et al.   EUROPEAN JOURNAL OF NEUROLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Phosphorylation of p65(RelA) on Ser547 by ATM Represses NF-κB-Dependent Transcription of Specific Genes after Genotoxic Stress

(2012) Hélène Sabatel et al.   PLoS One

ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

(2012) A. J. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Vascular Deficiency in Retinal Pathology in a Mouse Model of Ataxia-Telangiectasia

(2011) Dorit Raz-Prag et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

Efficacy of very-low-dose betamethasone on neurological symptoms in ataxia-telangiectasia

(2010) T. Broccoletti et al.   EUROPEAN JOURNAL OF NEUROLOGY

Elevated Serum IL-8 Levels in Ataxia Telangiectasia

(2010) Sharon A. McGrath-Morrow et al.   JOURNAL OF PEDIATRICS

Mechanisms and resistance in glucocorticoid control of inflammation

(2010) Peter J. Barnes   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

(2010) A. Bensimon et al.   Science Signaling

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Steroid-induced improvement of neurological signs in ataxia-telangiectasia patients

(2008) T. Broccoletti et al.   EUROPEAN JOURNAL OF NEUROLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY