Article
Ecology
Neelam Rawat, Saurabh Purohit, Vikas Painuly, Govind Singh Negi, Mahendra Pratap Singh Bisht
Summary: This study models the current and future potential habitat distribution of the endangered medicinal plant Picrorhiza kurroa in the Uttarakhand Himalaya region using the maximum entropy model. The results show that precipitation, isothermality, mean temperature of the warmest quarter, and temperature annual range are important factors influencing the habitat of P. kurroa. Overall, the habitat of P. kurroa is expected to decrease under climate change scenarios.
ECOLOGICAL INFORMATICS
(2022)
Review
Biochemistry & Molecular Biology
Anikesh Bhardwaj, Ajay Sharma, Raymond Cooper, Garima Bhardwaj, Jyoti Gaba, Vishal Mutreja, Arjun Chauhan
Summary: Secondary metabolites from natural sources have been crucial in healthcare throughout history. Around 60% of recently approved drugs are derived from natural sources. Picrorhiza kurroa, a widely used plant in traditional medicine of the Himalayan region, possesses diverse pharmacological properties and is facing the threat of being endangered due to overexploitation.
PROCESS BIOCHEMISTRY
(2021)
Article
Plant Sciences
Avinash Kumar, Vijay Rani Rajpal, Ambika, Rachayya Mallikarjun Devarumath, Amita Kumari, Rakesh Thakur, Manju Chaudhary, Pradeep Pratap Singh, Shiv Murat Singh Chauhan, Soom Nath Raina
Summary: Picrorhiza kurroa is a medicinally important herb endemic to the Himalayas, possessing strong hepato-protective bioactivity from picroside compounds. Genetic and phytochemical diversity in 124 and 91 genotypes from 10 Himalayan populations were assessed using DNA fingerprinting and HPLC. The study revealed high genetic diversity and the potential for future resource management and conservation strategies in P. kurroa.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2021)
Article
Chemistry, Analytical
Bindu Rawat, Pradeep Bhatia, Manish Kumar, Pawan Kumar, Dinesh Kumar
Summary: The study aimed to develop and validate a new method for simultaneous estimation of active compounds in Picrorhiza. The method was found to be accurate, reliable, and significant for the determination of various components in Picrorhiza.
JOURNAL OF ANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Jawaher Alkahtani, Asma Asma, Muhammad Adil, Abdur Rashid, Turki M. Dawoud, Ahmed A. Alsofi, Mohamed Ragab Abdel Gawwad, Mohamed M. A. Elshaer
Summary: This study evaluated the therapeutic value and phytoconstituents of Nepeta distans. Four known compounds were identified in the methanol extract, and various phytochemicals were found to be present. The antimicrobial activities of both the methanol extract and chloroform fraction were significant.
JOURNAL OF FOOD QUALITY
(2022)
Article
Plant Sciences
Vijay Laxmi Trivedi, Sudeep Chandra, M. C. Nautiyal
Summary: The study evaluated the impact of P. polystachyum on the morpho-physiology and biochemistry of Picrorhiza kurroa in the Western Himalayan alpine regions. It was found that Picrorhiza kurroa plants growing with P. polystachyum showed better growth and physiological characteristics, demonstrating greater adaptability.
ACTA PHYSIOLOGIAE PLANTARUM
(2022)
Review
Integrative & Complementary Medicine
Ashwinikumar Raut, Hiteshi Dhami-Shah, Aashish Phadke, Anand Shindikar, Shobha Udipi, Jayashree Joshi, Rama Vaidya, Ashok D. B. Vaidya
Summary: Kutki (P.kurroa) is an important medicinal plant traditionally used in Ayurveda for millennia, and there has been a renewed interest in its pharmacology, pharmacognosy, and phytochemistry. The hepatoprotective activity of P.kurroa has been correlated with specific phytochemical constituents, particularly picrosides. To effectively translate traditional remedies into modern therapy, understanding the molecular actions, drug targets, efficacy, safety, and convenient dosage forms is necessary. This review demonstrates the potential translation of using P.kurroa for fatty liver disease based on phytochemical standardization and clinical targeting.
JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE
(2023)
Article
Plant Sciences
Ishfaq Ahmad Wani, Susheel Verma, Parvaiz Ahmad, Hamed A. El-Serehy, Maha J. Hashim
Summary: Information on reproductive biology and pollination ecology studies of threatened plants are essential for sustainable utilization and effective conservation strategies. In this study, reproductive behavior and pollination mechanisms of Rheum webbianum, a vulnerable medicinal herb, were investigated. The species exhibits unique reproductive events and cold survival strategies. The flowers have temporally separated male and female phases, and the stigma lobes move upward after anthesis, facilitating outcrossing. The species is self-compatible and cross-fertile based on pollen/ovule ratio estimates and pollination experiments.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agronomy
A. Singh, M. C. Nautiyal, R. N. Curti, G. Fenu
Summary: Research on the phenological stages of the medicinal plant Megacarpaea polyandra in the Himalayan region revealed a long juvenile vegetative phase and the importance of root storage for resource translocation during reproduction. The application of the BBCH scale identified leaf development phase as critical for this species, with implications for conservation and sustainable use among Himalayan farmers.
GENETIC RESOURCES AND CROP EVOLUTION
(2022)
Article
Plant Sciences
Roma Pandey, Ashish Sharma, Hemant Sood, Rajinder Singh Chauhan
Summary: This study reveals potential clues on ABC transporters involved in long distance and local transport of picrosides in P. kurroa organs, and further unravels important interactions with additional components of biosynthetic machinery through co-expression network analysis.
Article
Biochemistry & Molecular Biology
Anjali Kharb, Rajinder S. Chauhan
Summary: By studying the differential transcriptomes of Picrorhiza kurroa in different tissues with varying P-I and P-II contents, paralogues of pathway genes associated with P-I and P-II contents have been identified and prioritized.
MOLECULAR GENETICS AND GENOMICS
(2021)
Article
Plant Sciences
Shabeer Ahmad Dar, Irshad Ahmad Nawchoo, Sumira Tyub, Azra Nahaid Kamili
Summary: The study aimed to develop a reliable tissue culture protocol for the critically endangered herb Atropaacuminata Royle and evaluate its primary biochemical attributes and antioxidant activities. The results showed that the addition of BAP and IAA to the MS media resulted in the best regeneration of shoots.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT
(2022)
Review
Integrative & Complementary Medicine
Tareq A. Wani, Zahoor A. Kaloo, Nisar A. Dangroo
Summary: Aconitum heterophyllum is a critically endangered medicinal herb with rich potential for use in medicine. It is the only nonpoisonous member of the Aconitum genus and has been used in traditional medicine for centuries. Studies have shown that A. heterophyllum possesses analgesic, anti-inflammatory, antiarrhythmic, antiparasitic, and anticancer properties. This review provides an overview of its classification, distribution, commerce, traditional uses, phytochemistry, pharmacology, and conservation measures, as well as the biosynthetic pathways of its key constituents.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Environmental Sciences
Praveen Joshi, Prem Prakash, Vijay Kant Purohit
Summary: Paeonia emodi is an important wild edible species in the Garhwal Himalaya, but it is facing a severe threat to its sustainability. This study investigated anthropogenic pressure, population decline perceptions, and vulnerability assessment. The findings provide valuable insights for conservation and management decisions.
JOURNAL OF MOUNTAIN SCIENCE
(2023)
Article
Plant Sciences
Harouna Diete Souleymane, Alfa Keita Djibo, Sabo Haoua Seyni, Ousseini Zakaria, Andreea Veronica Botezatu, Rodica Mihaela Dinica, Adamou Ibrahim Maman Laouali, N'goran David Vincent Kouakou
Summary: Sickle cell anaemia is a severe health problem in Niger, and the associated medical costs are high. This study aimed to treat sickle cell disease using extracts from two plants in Niger. The extracts contained bioactive compounds known for their valuable biological activities and showed promising results in inhibiting sickle cell formation in vitro. These findings may support the use of these plants in traditional medicine for sickle cell disease in Niger.
