Article
Surgery
Tommaso Maria Manzia, Quirino Lai, Hermien Hartog, Virginia Aijtink, Marco Pellicciaro, Roberta Angelico, Carlo Gazia, Wojciech G. Polak, Massimo Rossi, Giuseppe Tisone
Summary: This study aimed to evaluate the role of the graft-to-recipient weight ratio (GRWR) in adult liver transplantation and found that GRWR plays an important role in predicting early allograft dysfunction. The mEAD model developed in this study showed better predictive ability for graft loss, and could assist in improving graft allocation.
UPDATES IN SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan Schwarz, Alberto Benazzo, Daniela Dunkler, Moritz Muckenhuber, Lorenzo Del Sorbo, Matteo Di Nardo, Katharina Sinn, Bernhard Moser, Jose Ramon Matilla, Gyoergy Lang, Shahrokh Taghavi, Ferenc Renyi Vamos, Peter Jaksch, Marcelo Cypel, Shaf Keshavjee, Walter Klepetko, Konrad Hoetzenecker
Summary: In this study, the authors compared the prediction capability of PGD grades and a model derived from ventilation parameters measured on arrival at the ICU. They found that while PGD grades had limited value in predicting prolonged mechanical ventilation, the logistic regression model including ventilation parameters showed more stable and accurate prediction.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Nora Jahn, Maria Theresa Voelker, Sven Laudi, Sebastian Stehr, Stefan Schneeberger, Gerald Brandacher, Elisabeth Sucher, Sebastian Rademacher, Daniel Seehofer, Robert Sucher, Hans Michael Hau
Summary: The combination of peak lipase and CRP levels is highly effective in predicting early pancreatic graft dysfunction following simultaneous pancreas-kidney transplantation. However, this parameter has less predictive value for early renal graft dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Natasha Aleksova, Tayler A. Buchan, Farid Foroutan, Alice Zhu, Sean Conte, Peter Macdonald, Pierre-Emmanuel Noly, Michel Carrier, Silvana F. Marasco, Koji Takeda, Matteo Pozzi, Guillaume Baudry, Fernando A. Atik, Sven Lehmann, Khalil Jawad, Gavin W. Hickey, Antoine Defontaine, Oliver Baron, Antonio Loforte, Giulio Giovanni Cavalli, Daniel O. Absi, Masashi Kawabori, Michael A. Mastroianni, Maria Simonenko, Sandro Sponga, Yasbanoo Moayedi, Ani Orchanian-cheff, Heather J. Ross, Vivek Rao, Gordon Guyatt, Filio Billia, Ana C. Alba
Summary: This study evaluates the outcomes of VA-ECMO in adult heart transplant recipients through a systematic review and meta-analysis. The short-term and one-year mortality rates for patients receiving VA-ECMO were 33% and 50% respectively. Older age and prior sternotomy were associated with increased risk of short-term mortality. Early intraoperative cannulation and peripheral cannulation may reduce the risk of short-term death.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Surgery
Victoria Jernryd, Carsten Metzsch, Bodil Andersson, J. Gustav Smith, Johan Nilsson
Summary: This study aimed to investigate the feasibility of measuring cardiac biomarkers from the donor heart as predictors of PGD after heart transplantation. The results showed that high levels of CK-MB were associated with an increased risk of severe graft dysfunction, suggesting the potential for early identification of at-risk patients.
CLINICAL TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Isabel M. C. Hasse, Gerrit M. Grosse, Ramona Schuppner, Till Van Gemmeren, Maria M. Gabriel, Karin Weissenborn, Ralf Lichtinghagen, Hans Worthmann
Summary: IL-6 and LBP may predict outcome-relevant lower respiratory tract infections in early stages of AIS. However, blood biomarkers have limited predictive ability for total SAIs, further studies are needed to determine their use in identifying patients prone to SAIs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Torbjorn F. Heldal, Anders Asberg, Thor Ueland, Anna V. Reisaeter, Soren E. Pischke, Tom E. Mollnes, Pal Aukrust, Finn Reinholt, Anders Hartmann, Kristian Heldal, Trond G. Jenssen
Summary: Early systemic inflammation after kidney transplantation is associated with long-term graft pathology and loss, with particular emphasis on vascular inflammation scores correlating with inflammatory findings in biopsies 6 weeks and 1 year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
Lourdes Chacon-Alberty, Shengbin Ye, Daoud Daoud, William C. Frankel, Hassan Virk, Jonathan Mase, Camila Hochman-Mendez, Meng Li, Luiz C. Sampaio, Doris A. Taylor, Gabriel Loor
Summary: Sex and hormones can impact immune responses to ischemia reperfusion (IR) and potentially lead to gender differences in lung transplantation outcomes. Women have a more sustained proinflammatory response than men after LTx, even though they experience a greater reduction in PGD over time. The interaction between cytokine responses and PGD evolution warrants further investigation for potential tailored treatments during or after transplantation.
RESPIRATORY RESEARCH
(2021)
Review
Immunology
Hailey M. Shepherd, Jason M. Gauthier, Yuriko Terada, Wenjun Li, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel
Summary: Ischemia-reperfusion injury is a crucial event during organ transplantation and has a significant impact on early graft dysfunction in lung, heart, liver, and kidney transplant recipients. Recent studies have highlighted the role of recipient neutrophils in this process and demonstrated that early innate immune responses may affect the outcome of the graft.
Article
Cardiac & Cardiovascular Systems
John J. Squiers, J. Michael DiMaio, Johanna Van Zyl, Brian Lima, Gonzalo Gonzalez-Stawisnksi, Aldo E. Rafael, Dan M. Meyer, Shelley A. Hall
Summary: This retrospective study analyzed data from consecutive cardiac transplant patients at a single center between 2012 and 2015, finding that patients with moderate to severe PGD had increased mortality risk up to 5 years post-transplant. However, patients with moderate to severe PGD who survived the first 90 days post-transplant no longer had a higher risk of mortality compared to those with mild or no PGD.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cell & Tissue Engineering
C. Ruiz-Fernandez, D. Ait Eldjoudi, M. Gonzalez-Rodriguez, A. Cordero Barreal, Y. Farrag, L. Garcia-Caballero, F. Lago, A. Mobasheri, D. Sakai, J. Pino, O. Gualillo
Summary: In this study, the significance of monomeric C-reactive protein (mCRP) in the pathogenesis and progression of intervertebral disc degeneration was investigated. The results demonstrated that mCRP can be localized in intervertebral disc tissues, where it induces an inflammatory and catabolic state. NF-KB signaling may be involved in mediating this mCRP-induced state.
BONE & JOINT RESEARCH
(2023)
Article
Multidisciplinary Sciences
Pierre-Emmanuel Noly, Suyash Naik, Paul Tang, Ienglam Lei
Summary: Primary graft dysfunction (PGD) is the leading cause of early death after heart transplantation. This study presents a technique for assessing murine cardiac function using ex vivo perfusion, which allows reliable evaluation of cardiac function after different heart preservation protocols. This technique enables investigation of cardiac preservation responses specifically in native cardiac cells and the mechanisms of PGD using transgenic mice.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Surgery
Matthew R. Carey, Annamaria Ladanyi, Yonatan Mehlman, Rebecca L. Molinsky, Andrew Eisenberger, Kevin J. Clerkin, Justin G. Aaron, Koji Takeda, Gabriel T. Sayer, Nir Uriel, Ryan T. Demmer, Paolo C. Colombo, Melana Yuzefpolskaya
Summary: Heart transplantation is an effective treatment for advanced heart failure, but is associated with complications. This study investigated the outcomes of heart transplantation in patients with pre-existing hematologic disorders, and found an increased risk of complications without significant differences in mortality rates.
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Scott T. Chiesa, Marietta Charakida, Georgios Georgiopoulos, Justin D. Roberts, Simon J. Stafford, Chloe Park, Juha Mykkanen, Mika Kahonen, Terho Lehtimaki, Mika Ala-Korpela, Olli Raitakari, Milla Pietiainen, Pirkko Pussinen, Vivek Muthurangu, Alun D. Hughes, Naveed Sattar, Nicholas J. Timpson, John E. Deanfield
Summary: GlycA is associated with the development of cardiovascular disease risk and predicts the risk of hypertension and metabolic syndrome. In contrast, CRP has little correlation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Surgery
Vinayak S. Rohan, Nicole Pilch, John McGillicuddy, Jared White, Angello Lin, Derek Dubay, David J. Taber, Prabhakar K. Baliga
Summary: This study aimed to evaluate the operational, financial, and recipient-related effects of the new kidney allocation system on a large rural transplantation program. The results showed a decrease in the quality and success rate of donor kidneys, leading to increasing logistical and financial burdens on the system.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
