Article
Clinical Neurology
Fernando L. Pagan, Barbara Wilmarth, Yasar Torres-Yaghi, Michaeline L. Hebron, Sanjana Mulki, Dalila Ferrante, Sara Matar, Jaeil Ahn, Charbel Moussa
Summary: The study showed that nilotinib is safe and well tolerated in Parkinson's disease patients. Clinical data indicated that nilotinib 300mg had stable effects on Parkinson's symptoms, while the 150mg dose showed significant declines. Starting with the 150mg dose late in the disease progression worsened symptoms, and quality of life decreased with 150mg but remained stable with 300mg.
MOVEMENT DISORDERS
(2021)
Article
Oncology
Suzanne L. Topalian, Mario Sznol, David F. McDermott, Harriet M. Kluger, Richard D. Carvajal, William H. Sharfman, Julie R. Brahmer, Donald P. Lawrence, Michael B. Atkins, John D. Powderly, Philip D. Leming, Evan J. Lipson, Igor Puzanov, David C. Smith, Janis M. Taube, Jon M. Wigginton, Georgia D. Kollia, Ashok Gupta, Drew M. Pardoll, Jeffrey A. Sosman, F. Stephen Hodi
Summary: PD-1 blockade therapy can effectively reduce tumors and improve survival rates in patients with advanced melanoma.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Immunology
Klaus Nunes Ficher, Yasmin Dreige, Paulo Ricardo Gessolo Lins, Alexandra Nicolau Ferreira, Juliana Toniato de Rezende Freschi, Kamilla Linhares, Suelen Stopa Martins, Luciana Custodio, Marina Cristelli, Laila Viana, Daniel Wagner Santos, Renato de Marco, Maria Gerbase-DeLima, Henrique Proenca, Wilson Aguiar, Monica Nakamura, Claudia Rosso Felipe, Jose Medina Pestana, Helio Tedesco Silva Jr
Summary: This study analyzed the long-term efficacy and safety of everolimus or mycophenolate in combination with tacrolimus for kidney transplant recipients. The results showed that in de novo low/moderate immunologic risk patients, using a single dose of rabbit antithymocyte globulin followed by reduced tacrolimus concentrations and everolimus resulted in similar effectiveness and renal function compared to the standard immunosuppressive regimen.
Article
Clinical Neurology
Danilo Genovese, Francesco Bove, Leonardo Rigon, Tommaso Tufo, Alessandro Izzo, Paolo Calabresi, Anna Rita Bentivoglio, Carla Piano
Summary: This study assessed the clinical safety and efficacy of frameless bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients at 5 years after surgery. The results demonstrate that this technique is safe and well-tolerated, with sustained motor efficacy at 5 years post-surgery.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Tomer Goldberg, Yonatan Redlich, David Yogev, Tsvia Fay-Karmon, Sharon Hassin-Baer, Saar Anis
Summary: This study examined the long-term impact of medical cannabis (MC) on Parkinson's disease (PD) and found that MC treatment regimens appeared to be safe and did not exacerbate neuropsychiatric symptoms or have detrimental effects on disease progression.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Ying-Cheng Lin, Yen-Ju Chen, Shou-Wu Lee, Teng-Yu Lee, Yi-Hsing Chen, Wen-Nan Huang, Sheng-Shun Yang, Yi-Ming Chen
Summary: The risk of HBV-associated hepatitis after glucocorticoid pulse therapy in HBsAg-negative, anti-HBc-positive rheumatic patients was low, with no cases diagnosed within the first year. However, HBsAg seroreversion may occur later, specifically in patients maintained on high-dose oral steroids.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Matthew T. Rocco, Asad S. Akhter, Debra J. Ehrlich, Gretchen C. Scott, Codrin Lungu, Vikas Munjal, Anthony Aquino, Russell R. Lonser, Massimo S. Fiandaca, Mark Hallett, John D. Heiss, Krystof S. Bankiewicz
Summary: This study investigated the direct infusion of adeno-associated virus vector (AAV2) containing the GDNF transgene into the putamen of patients with advanced Parkinson's disease. Real-time intraoperative magnetic resonance imaging (iMRI) using a surrogate imaging tracer was used to track the distribution of the infused substance. The results confirmed the safety and efficacy of this delivery method, with no evidence of cerebral toxicity observed in the long-term follow-up. The use of real-time imaging during the procedure allows for precise placement of the infusion cannula and adjustment of infusion rate, improving the safety and effectiveness of the treatment.
Article
Clinical Neurology
Federica Garri, Francesco Paolo Russo, Tommaso Carrer, Luca Weis, Francesca Pistonesi, Michele Mainardi, Michele Sandre, Edoardo Savarino, Fabio Farinati, Francesca Del Sorbo, Paola Soliveri, Daniela Calandrella, Roberta Biundo, Miryam Carecchio, Anna Lena Zecchinelli, Gianni Pezzoli, Angelo Antonini
Summary: This study retrospectively analyzed the usage of LCIG in 79 patients with Parkinson's disease and found that it has a relatively satisfactory long-term safety profile and efficacy, with a low rate of discontinuation. Peristomal complications may be a predictor of longer duration of therapy.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Craig D. Newgard, Amber Lin, Susan Malveau, Jennifer N. B. Cook, McKenna Smith, Nathan Kuppermann, Katherine E. Remick, Marianne Gausche-Hill, Jeremy Goldhaber-Fiebert, Randall S. Burd, Hilary A. Hewes, Apoorva Salvi, Haichang Xin, Stefanie G. Ames, Peter C. Jenkins, Jennifer Marin, Matthew Hansen, Nina E. Glass, Avery B. Nathens, K. John McConnell, Mengtao Dai, Brendan Carr, Rachel Ford, Davis Yanez, Sean R. Babcock, Benjamin Lang, N. Clay Mann
Summary: It is unclear if high pediatric readiness in emergency departments (EDs) is associated with lower mortality among children with diverse clinical conditions. This study aimed to evaluate the association between ED pediatric readiness and in-hospital and 1-year mortality among injured and medically ill children.
Article
Clinical Neurology
Atsushi Takeda, Ryosuke Takahashi, Yoshio Tsuboi, Masahiro Nomoto, Tetsuya Maeda, Akihisa Nishimura, Kazuo Yoshida, Nobutaka Hattori
Summary: The double-blind part of the COMFORT-PD study in Japanese levodopa-treated patients with Parkinson's disease and motor fluctuations showed that both opicapone 25 and 50 mg were more effective than placebo. The 52-week open-label extension study demonstrated that opicapone 50 mg tablets were well tolerated and consistently reduced OFF-time in patients who completed the initial double-blind part of the study.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Medicine, General & Internal
Katherine E. Olson, Krista L. Namminga, Yaman Lu, Aaron D. Schwab, Mackenzie J. Thurston, Mai M. Abdelmoaty, Vikas Kumar, Melinda Wojtkiewicz, Helen Obaro, Pamela Santamaria, R. Lee Mosley, Howard E. Gendelman
Summary: The study showed that long-term treatment with 3 micrograms/kilogram/day of sargramostim significantly reduced the number and severity of adverse events, while improving immune function and alleviating Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale scores. This dosage regimen is effective and well-tolerated for restoring immune homeostasis.
Article
Nutrition & Dietetics
Lotte E. Vlug, Patric J. D. Delhanty, Esther G. Neelis, Martin Huisman, Jenny A. Visser, Edmond H. H. M. Rings, Rene M. H. Wijnen, Sjoerd C. J. Nagelkerke, Merit M. Tabbers, Jessie M. Hulst, Barbara A. E. de Koning
Summary: Children with intestinal failure have elevated levels of ghrelin, which may be related to gut starvation. The dose of parenteral nutrition is positively correlated with ghrelin levels.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Stephen Salerno, Joseph M. Messana, Garrett W. Gremel, Claudia Dahlerus, Richard A. Hirth, Peisong Han, Jonathan H. Segal, Tao Xu, Dan Shaffer, Amy Jiao, Jeremiah Simon, Lan Tong, Karen Wisniewski, Tammie Nahra, Robin Padilla, Kathryn Sleeman, Tempie Shearon, Sandra Callard, Alexander Yaldo, Lisa Borowicz, Wilfred Agbenyikey, Golden M. Horton, Jesse Roach, Yi Li
Summary: This study evaluated COVID-19 risk factors and outcomes among Medicare patients receiving long-term dialysis, finding that Black and Hispanic patients, as well as patients with extended nursing home stays, were more likely to contract COVID-19 and experience mortality.
Article
Geriatrics & Gerontology
Lauren B. Gerlach, Shekinah Fashaw, Julie Strominger, Jessica Ogarek, Andrew R. Zullo, Lori A. Daiello, Joan Teno, Theresa I. Shireman, Julie P. W. Bynum
Summary: The study assessed the impact of the CMS National Partnership on antipsychotic prescribing trends among long-term care residents in hospice, finding a decline in antipsychotic prescribing among long-term care residents in hospice. The results suggest that this initiative has a positive effect on antipsychotic medication use in long-term care facilities.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Astronomy & Astrophysics
Prantik Nandi, Arka Chatterjee, Sandip K. Chakrabarti, Broja G. Dutta
Summary: The study analyzed the long-term X-ray spectral and temporal properties of a bare-type AGN, revealing that spectral variations can be explained by changes in accretion dynamics. The correlation between X-ray time delays and soft-excess suggests a common physical process.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)