Article
Medicine, General & Internal
Claire Y. Li, Timothy Kennedy, Henry Richard Alexander
Summary: Malignant peritoneal mesothelioma is a rare malignancy that is diagnosed through cross sectional imaging and tissue biopsy. Surgical cytoreduction and chemotherapy are the preferred treatments, providing prolonged benefits to many patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Daya K. Jha, Pankaj Gupta, Pardhu B. Neelam, Rajender Kumar, Venkata S. Krishnaraju, Manish Rohilla, Ajay S. Prasad, Usha Dutta, Vishal Sharma
Summary: It is difficult to differentiate between tuberculous peritonitis and peritoneal carcinomatosis, but the combination of clinical features and radiological findings can provide more accurate diagnostic results.
Article
Chemistry, Multidisciplinary
Michael G. Wientjes, Ze Lu, Carlos H. F. Chan, Kiran Turaga, Jessie L. S. Au
Summary: Cytoreductive surgery (CRS) along with intraperitoneal chemotherapy (IPC) is used for the treatment of peritoneal metastasis (PM). However, the efficacy of this treatment varies and limited research has been done on the effects of pharmaceutical properties. This study found that paclitaxel binds tightly to proteins in patient ascites, which may lead to diminished efficacy of CRS in PM patients with ascites.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Oncology
Margaret Y. Y. Han, Erkut H. H. Borazanci
Summary: Malignant ascites is a complication of advanced cancer that often signifies the terminal phase of the disease. Previous studies have focused on ovarian and gastric cancer, but there has been an increase in research on malignant ascites in pancreatic cancer. The current standard of care involves symptom palliation, but there is a need for novel diagnostic tools and treatment strategies. This review summarizes the current understanding of malignant ascites in pancreatic cancer, including molecular characterization and potential investigative directions.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Mefotse Saha Cyrelle Ornella, Narayanasamy Badrinath, Kyeong-Ae Kim, Jung Hee Kim, Euna Cho, Tae-Ho Hwang, Jae-Joon Kim
Summary: Peritoneal carcinomatosis is a challenging condition that has limited treatment options. However, recent advances in immunotherapy, such as immune checkpoint inhibitors and CAR-T cells, show promise in improving outcomes for patients. Combining different immunotherapeutic approaches may further enhance treatment efficacy. Further research is needed, but immunotherapy holds potential as an effective and tolerable treatment for peritoneal carcinomatosis.
Article
Biochemistry & Molecular Biology
Pawel Uruski, Justyna Mikula-Pietrasik, Martyna Pakula, Sylwia Budkiewicz, Marcin Drzewiecki, Andrey N. Gaiday, Malgorzata Wierzowiecka, Eryk Naumowicz, Rafal Moszynski, Andrzej Tykarski, Krzysztof Ksiazek
Summary: This study found that malignant ascites (MAs) promoted the adhesion of cancer cells to peritoneal cells more efficiently than benign ascites (BAs), possibly through the modulation of various growth factors affecting the interaction between cancer cells and normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hunghao Chu, Ivan T. Rebustini, S. Patricia Becerra, Yadong Wang
Summary: In this study, the amino acid sequence of PEDF was modified to increase its affinity for heparin and hyaluronic acid, leading to improved retention in the retina microenvironment. The engineered PEDF exhibited antiangiogenic and retinal survival bioactivities, making it a potential therapeutic drug for retinal diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Omar Alshuwaykh, Amanda Cheung, Aparna Goel, Allison Kwong, Renumathy Dhanasekaran, T. Tara Ghaziani, Aijaz Ahmed, Tami Daugherty, Deepti Dronamraju, Radhika Kumari, Mindie Nguyen, W. Ray Kim, Paul Yien Kwo
Summary: This study analyzed the characteristics of ascites and clinical outcomes in patients with extrahepatic solid tumors. It found that peritoneal carcinomatosis was the most common cause of ascites, and patients with liver metastasis had higher mortality rates. These findings are important for predicting prognosis and developing treatment strategies.
BMC GASTROENTEROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Anmin Huang, Feixia Guo, Zhijie Yu, Pixu Liu, Shiying Dong, Yunjie Zhang, Yifan Kong, Xiuyan Kong, Ting Li, Yongde Luo, Hongping Xia, Keqing Shi, Jinglin Xia
Summary: Malignant ascites is a common symptom of peritoneal metastasis in liver cancer, and cancer immunotherapy can modulate immune cells to induce antitumor immune efficiency. In this study, engineered apoptosis-bioinspired nanoparticles (EBN) were proposed and studied for cancer immunotherapy of malignant ascites. Through in vitro and in vivo experimental validations, EBN was found to efficiently engulf tumor-associated macrophages (TAMs) and manipulate their polarization, leading to an enhanced immune cascade response. Furthermore, injection of EBN reduced ascites volume and reformed immune cell subtypes compared to other treatments.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Oncology
Tetsuo Tani, Ichiro Nakachi, Shinnosuke Ikemura, Shigenari Nukaga, Keiko Ohgino, Aoi Kuroda, Hideki Terai, Keita Masuzawa, Taro Shinozaki, Kota Ishioka, Yohei Funatsu, Hidefumi Koh, Koichi Fukunaga, Kenzo Soejima
Summary: Metastatic peritoneal carcinomatosis (MPC) is uncommon in NSCLC patients, and treatment interventions can significantly improve prognosis, especially for patients with driver oncogenes and good performance status, who tend to have longer overall survival.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yusuke Kono, Aya Fushimi, Yuta Yoshizawa, Kazutaka Higaki, Ken-ichi Ogawara
Summary: Malignant ascites causes symptoms such as abdominal pain, dyspnea, and anorexia, which decrease the quality of life for cancer patients. In this study, nanoparticulate drug delivery systems were used to manage malignant ascites and increase the effectiveness of anti-cancer drugs. The results showed that particle size and drug release property are key factors in determining the biodisposition and therapeutic efficacy of intraperitoneally injected nanoparticulate drugs against malignant ascites.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Oncology
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Angela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolanos, Jose Gonzalez-Gomariz, Maite Alvarez, Inaki Etxeberria, Belen Palencia, Alvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Summary: Previous studies have found that local delivery of tumor antigen-specific CD8(+) T lymphocytes transiently expressing single-chain IL-12 mRNA is highly effective in treating tumors. In this study, intracavitary adoptive T cell therapy was used to treat peritoneal dissemination of B16-OVA and PANC02-OVA tumors, and it was found that intraperitoneal administration of T cells promoted homing to the omentum more effectively than intravenous administration. Transient IL-12 expression resulted in a favorable reprogramming of the tumor immune microenvironment and longer persistence of transferred T lymphocytes, leading to the development of immunity to endogenous antigens after primary tumor eradication.
Article
Medicine, General & Internal
Tony Abi El Hessen, Shahzaib Saleem, Riad H. Hani, Fatima Z. Chadli, Jawad A. Makarem
Summary: Peritoneal tuberculosis is a rare disease that is most commonly seen in immunocompromised patients. It can be difficult to diagnose as it often mimics the symptoms and radiological manifestations of malignancy. We report a case of a patient who initially presented with symptoms suggestive of gynecological malignancy, but was ultimately diagnosed with peritoneal tuberculosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Endocrinology & Metabolism
Sabrina J. Ritch, Carlos M. Telleria
Summary: Epithelial ovarian cancer is the deadliest gynecological disease, commonly diagnosed at late stages with metastasis. Understanding the unique microenvironments that promote EOC dissemination is crucial in improving patient outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Sara Nasser, Aygun Babayeva, Ioana Braicu, Rolf Richter, Esra Bilir, Radoslav Chekerov, Mustafa-Zelal Muallem, Klaus Pietzner, Melissa-Guelhan Inci, Jalid Sehouli
Summary: This prospective study analyzed the different features of peritoneal carcinomatosis in ovarian cancer patients and found that diffuse peritoneal localization was a significant predictor of recurrence. Lower OS and PFS rates were associated with diffuse peritoneal localization, wet PC, and additional lymph node involvement.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Jing Liu, Dan Sun, Jinfeng He, Chengli Yang, Tingting Hu, Lijing Zhang, Hua Cao, Ai-ping Tong, Xiangrong Song, Yongmei Xie, Gu He, Gang Guo, Youfu Luo, Ping Cheng, Yu Zheng
Article
Oncology
Anliang Huang, Dan Yue, Danying Liao, Liuliu Cheng, Jinhu Ma, Yuquan Wei, Aiping Tong, Ping Cheng
Article
Oncology
Jun Yang, Xinyu Zhao, Mei Tang, Lei Li, Yi Lei, Ping Cheng, Wenhao Guo, Yu Zheng, Wei Wang, Na Luo, Yong Peng, Aiping Tong, Yuquan Wei, Chunlai Nie, Zhu Yuan
Article
Genetics & Heredity
Yuwei Zhang, Dan Yue, Liuliu Cheng, Anliang Huang, Nanwei Tong, Ping Cheng
JOURNAL OF MOLECULAR MEDICINE-JMM
(2018)
Article
Oncology
Anliang Huang, Jinhu Ma, Liyan Huang, Fan Yang, Ping Cheng
Article
Oncology
Heng-Xiu Yan, Ping Cheng, Hai-Yan Wei, Guo-Bo Shen, Li-Xin Fu, Jie Ni, Yang Wu, Yu-Quan Wei
Article
Oncology
Yingying Yan, Ning Liu, Lian Lu, Chuan-Mou Zang, Bin Shao, Yuhua Li, Yanjun Wen, Yuquan Wei, Ping Cheng
Article
Biotechnology & Applied Microbiology
Yuhua Li, Ling Wang, Tao Zhu, Shipo Wu, Liqiang Feng, Ping Cheng, Jingjing Liu, Junzhi Wang
HUMAN GENE THERAPY CLINICAL DEVELOPMENT
(2018)
Article
Pharmacology & Pharmacy
Jinhu Ma, Chao Su, Xilei Wang, Yongheng Shu, Shichuan Hu, Chengzhi Zhao, Yueting Kuang, Yanwei Chen, Yuhua Li, Yuquan Wei, Ping Cheng
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Yongheng Shu, Ping Cheng
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2020)
Article
Cell Biology
Yuwei Zhang, Yang Li, Tong Mu, Nanwei Tong, Ping Cheng
Summary: The study demonstrated that utilizing VitA-coupled cationic liposomes delivered TLR4 shRNA more efficiently to aHSCs compared to uncoupled cationic liposomes, both in vitro and in vivo conditions. TLR4 gene silencing inhibited HSCs activation and alleviated liver fibrosis through NF-kappa B transcriptional inactivation, pro-inflammatory cytokines secretion, and ROS synthesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jinhu Ma, Chao Su, Shichuan Hu, Yanwei Chen, Yongheng Shu, Dan Yue, Bin Zhang, Zhongbing Qi, Suli Li, Xilei Wang, Yueting Kuang, Ping Cheng
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2020)
Review
Oncology
Bin Zhang, Xilei Wang, Ping Cheng
Summary: Oncolytic viruses have unique therapeutic mechanisms, including direct oncolysis and induction of antitumor immunity. They can be genetically engineered to remodel the tumor immune microenvironment and enhance antitumor efficacy. Additionally, they can serve as vectors for delivering immunomodulatory cytokines or antibodies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Bin Zhang, Ping Cheng