Article
Medicine, General & Internal
Manizheh Mostafa Gharehbaghi, Majid Mhallei, Shalale Ganji, Sanaz Yasrebinia
Summary: The study shows that the combination of budesonide and surfactant can significantly reduce the incidence of BPD in preterm infants and shorten the duration of respiratory support.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2021)
Article
Pediatrics
Hajnalka Szabo, Eugenio Baraldi, Andrew A. Colin
Summary: This paper reviews the latest clinical trials investigating the effects of corticosteroids in the prevention and treatment of bronchopulmonary dysplasia (BPD). It found that inhaled postnatal corticosteroids can decrease the incidence of BPD, but also increase mortality rate in neonates. However, using intratracheal instillation of corticosteroids combined with surfactant can effectively reduce the occurrence of BPD without increasing mortality or long-term adverse outcomes.
PEDIATRIC PULMONOLOGY
(2022)
Article
Medicine, Research & Experimental
Brett J. Manley, C. Omar F. Kamlin, Susan Donath, Li Huang, Pita Birch, Jeanie L. Y. Cheong, Peter A. Dargaville, Jennifer A. Dawson, Lex W. Doyle, Susan E. Jacobs, Rodney Wilson, Peter G. Davis, Christopher J. D. McKinlay
Summary: This study aims to explore the method of administering budesonide mixed with surfactant through endotracheal tube or thin catheter in order to reduce the incidence of bronchopulmonary dysplasia in extremely preterm infants, and to improve their neurodevelopmental and respiratory outcomes.
Article
Obstetrics & Gynecology
Kalsang Dolma, Michael Zayek, Aayushka Gurung, Fabien Eyal
Summary: This study aimed to investigate the effect of intratracheal instillation of a budesonide-surfactant combination on the incidence of bronchopulmonary dysplasia (BPD) or death in extremely preterm infants. The results showed that budesonide reduced the rates of BPD or death in infants weighing ≥ 750 grams, but not in infants weighing <750 grams.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Dinesh Pawale, D. Saikiran, Rajendra Prasad Anne, Tejopratap Oleti, Srinivas Murki, Anurag Fursule
Summary: This study investigated the usage of less invasive surfactant administration (LISA) among neonatologists in India, and found that approximately 68.8% of the participants were using LISA. However, not all centers in India prefer LISA due to the absence of standardized training.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Wei Tang, Sisi Chen, Dongmei Shi, Tao Ai, Lei Zhang, Yijie Huang, Yinghong Fan, Yiting Du
Summary: Early combined utilization of budesonide and surfactant by airway shows superiority in preventing BPD in premature infants with RDS, reducing adverse outcomes, especially when budesonide is delivered by intratracheal instillation. More well-designed randomized controlled trials with larger sample sizes and longer follow-up from diverse populations are needed in the future.
PEDIATRIC PULMONOLOGY
(2022)
Article
Medicine, General & Internal
Michelle C. Starr, Russell Griffin, Katja M. Gist, Jeffrey L. Segar, Rupesh Raina, Ronnie Guillet, Saudamini Nesargi, Shina Menon, Nekayla Anderson, David J. Askenazi, David T. Selewski
Summary: This study describes fluid balance patterns in extremely low gestational age neonates and finds that peak fluid balance is associated with mechanical ventilation on postnatal day 14 and severe bronchopulmonary dysplasia (BPD) or death.
Article
Pediatrics
Laura Moschino, Daniel Nardo, Luca Bonadies, Matteo Stocchero, Giulia Res, Elena Priante, Sabrina Salvadori, Eugenio Baraldi
Summary: Comparing IT surfactant/budesonide (SB) with surfactant alone (S) in extremely preterm very low birth weight (VLBW) neonates with severe RDS did not show significant difference in reducing the rate of BPD or death at 36 weeks PMA. However, the combined treatment did result in lower incidence of hypotension requiring inotropic support and fewer admissions to pediatric ward due to respiratory causes.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pediatrics
Steven M. Conlon, Allison Osborne, Julie Bodie, Jaime Marasch, Rita M. Ryan, Tara Glenn
Summary: The study aimed to increase the percentage of surfactant delivered via LISA, with successful implementation of the technique in NICU after planning and training. Results showed that LISA was successfully carried out for eligible patients and only a small number of patients were unable to undergo the procedure.
Article
Multidisciplinary Sciences
Andre Gie, Yannick Regin, Arianna Mersanne, Jaan Toelen
Summary: Intratracheal drug delivery provides a direct way to deliver pharmaceutical substances to the lungs of premature animals, with the transcutaneous technique being simple and effective. This method is well tolerated by newborn pups and can be repeated for multiple consecutive days without affecting survival.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Respiratory System
Chun-cai Xu, Ying-ying Bao, Jing-xin Zhao, Ke Cheng, Ling Sun, Jing-yuan Wu, Ming-yuan Wu, Jia-jun Zhu
Summary: This study evaluated the effects of less invasive surfactant administration (LISA) and intubation-surfactant-extubation (InSurE) on bronchopulmonary dysplasia (BPD) in preterm infants with respiratory distress syndrome (RDS). The results showed no significant differences between the LISA and InSurE groups in terms of BPD incidence, severity of BPD, need for mechanical ventilation, and secondary outcomes.
BMC PULMONARY MEDICINE
(2022)
Article
Cell & Tissue Engineering
So Yoon Ahn, Yun Sil Chang, Myung Hee Lee, Se In Sung, Byong Sop Lee, Ki Soo Kim, Ai-Rhan Kim, Won Soon Park
Summary: The study demonstrated the safety and feasibility of MSC transplantation for BPD in preterm infants through a phase I clinical trial. The efficacy of MSCs for BPD treatment in premature infants was investigated in a phase II trial, where although inflammatory cytokines were significantly reduced, the overall primary outcome was not significantly improved. Subgroup analysis showed a significant improvement with MSC transplantation in the 23-24 GW group.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Pei-Chen Tsao, Chih-Hsueh Lin, Yu-Sheng Lee, Wei-Yu Chen, Mei-Jy Jeng, Yu Ru Kou
Summary: Intratracheal budesonide delivered by full-strength surfactant provides optimal protection against LPS-induced ALI in surfactant-insufficient rat lungs, as evidenced by improved gas exchange, reduced lung injury scores, and lower levels of inflammatory markers compared to other treatment groups.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Physiology
Andrea Porzionato, Patrizia Zaramella, Arben Dedja, Diego Guidolin, Luca Bonadies, Veronica Macchi, Michela Pozzobon, Marcin Jurga, Giorgio Perilongo, Raffaele De Caro, Eugenio Baraldi, Maurizio Muraca
Summary: The study demonstrated the protective effects of intratracheally-administered extracellular vesicles secreted by mesenchymal stem cells in a rat model of bronchopulmonary dysplasia, with prevention of morphometric changes induced by hyperoxia exposure in the long term. The findings further support the potential of intratracheally-administered EVs as an effective approach to prevent/treat BPD, with a possible role of M2 macrophage polarization.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Pediatrics
Rose M. Viscardi, Michael L. Terrin, Laurence S. Magder, Natalie L. Davis, Susan J. Dulkerian, Ken B. Waites, Marilee Allen, Ajoke Ajayi-Akintade, Namasivayam Ambalavanan, David A. Kaufman, Pamela Donohue, Deborah J. Tuttle, Jorn-Hendrik Weitkamp
Summary: The study found no significant difference in long-term pulmonary and neurodevelopmental outcomes in preterm infants treated with azithromycin in the first week of life compared to a placebo. Infants with tracheal aspirate Ureaplasma positivity had a higher risk of death or serious respiratory morbidity at 22-26 months corrected age.
PEDIATRIC RESEARCH
(2022)
