Article
Neurosciences
Nicholas A. Hubbard, Monroe P. Turner, Kevin R. Sitek, Kathryn L. West, Jakub R. Kaczmarzyk, Lyndahl Himes, Binu P. Thomas, Hanzhang Lu, Bart Rypma
Summary: By using calibrated functional magnetic resonance imaging, this study found that low-frequency fluctuations of cerebral metabolic rate of oxygen (CMRO2) during resting state exhibited organizational properties similar to previous functional and anatomical connectivity studies. Furthermore, voxel-wise CMRO2 connectivity showed spatial patterns consistent with four specific resting-state subnetworks.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Dana DeMaster, Beata R. Godlewska, Mingrui Liang, Marina Vannucci, Taya Bockmann, Bo Cao, Sudhakar Selvaraj
Summary: This study aimed to investigate the influence of brain regions on each other in patients with depression and explore the relationship with treatment response. The results showed widespread dysfunction of rsEC in patients with depression, and the connectivity strength was related to baseline depression severity and treatment response. This suggests that functional rsEC may be useful for predicting the effectiveness of antidepressant treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Laura M. Tully, Annchen R. Knodt, Janina Jiang, Michael R. Irwin, Camelia E. Hostinar
Summary: The study found associations between peripheral inflammation and adolescent brain connectivity, with higher TNF-α levels linked to changes in neural network connections. Associations with IL-6 and CRP were not significant, suggesting that inflammation may have unique effects on brain connectivity during adolescence.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Suyu Bi, Yun Guan, Lixia Tian
Summary: Both movie and resting-state functional MRI are effective and promising techniques for predicting brain age, but there are some differences in connectivity properties, particularly involving components of the default mode network.
Article
Neurosciences
Lu Zhang, Jiajia Zhao, Qunjie Zhou, Zhaowen Liu, Yi Zhang, Wei Cheng, Weikang Gong, Xiaoping Hu, Wenlian Lu, Edward T. Bullmore, Chun-Yi Zac Lo, Jianfeng Feng
Summary: This study analyzed large-scale resting-state functional magnetic resonance imaging data and identified transitions between sensory, somatomotor, and internal mentation networks in the resting brain. With increasing age, the internal mentation network becomes more prevalent, while sensory and somatomotor networks are more frequently expressed in younger individuals. The findings demonstrate the dynamic patterns of transition between functionally specialized brain states associated with age.
Article
Neurosciences
Limin Peng, Zhiguo Luo, Ling-Li Zeng, Chenping Hou, Hui Shen, Zongtan Zhou, Dewen Hu
Summary: This study developed a brain parcellation method based on dynamic functional connectivity and created a new functional brain atlas. The atlas can reveal finer functional boundaries that static methods may overlook, and shows good agreement with cytoarchitectonic areas and task activation maps.
Article
Neurosciences
Jung-Hoon Kim, Josepheen De Asis-Cruz, Kushal Kapse, Catherine Limperopoulos
Summary: The reliability and robustness of rs-fcMRI depend on minimizing the influence of head motion on brain signals. This study examined the impact of head motion on newborn brain connectivity using a large dataset. The findings revealed that head motion significantly affected connectivity, with specific effects observed in sensory-related and default mode networks. Implementing a motion correction strategy helped reduce the confounding effects of head motion on neonatal rs-fcMRI.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Marie-Stephanie Cahart, Owen O'Daly, Vincent Giampietro, Maarten Timmers, Johannes Streffer, Steven Einstein, Fernando Zelaya, Flavio Dell'Acqua, Steven C. R. Williams
Summary: This study compared the reliability of conventional single-band fMRI and different multiband (MB) fMRI acquisitions with and without in-plane acceleration across multiple scanning sessions. It found that for cortical areas, MB factor 4 without in-plane acceleration had the highest reliability, while for subcortical areas, conventional single-band fMRI was more reliable.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Guo-Rong Wu, Nigel Colenbier, Sofie Van den Bossche, Kenzo Clauw, Amogh Johri, Madhur Tandon, Daniele Marinazzo
Summary: The study introduces a Matlab and Python toolbox called rsHRF for estimating and deconvolving the HRF from resting-state BOLD signals, aiming to improve the analysis and understanding of the components and variability of BOLD signals.
Article
Neurosciences
Yongfa Zhang, Fei Wang, Jie Sui
Summary: Recent research supports a fundamental self hypothesis, suggesting that the self is a baseline function of the brain that regulates cognitive processing and behavior. Understanding this hypothesis can help identify the emergence of self-biased behaviors and predict the influence of brain signals at rest on such behaviors.
Article
Neurosciences
Shachar Gal, Yael Coldham, Niv Tik, Michal Bernstein-Eliav, Ido Tavor
Summary: The search for an ideal approach to investigate functional connections in the human brain is a challenge for neuroscience. Recent studies have found that using naturalistic stimuli to collect functional connectivity data predicts cognitive and emotional scores more accurately than using resting-state data. Furthermore, activation maps predicted using naturalistic stimuli are better predictors of individual intelligence scores than those predicted using resting-state data.
Article
Neurosciences
Luoyao Pang, Huidi Li, Quanying Liu, Yue-Jia Luo, Dean Mobbs, Haiyan Wu
Summary: Motivated dishonesty is a common social behavior that varies among individuals. This study explores the relationship between brain networks and dishonesty using resting-state functional magnetic resonance imaging (rsfMRI), and demonstrates the ability to predict dishonest behavior through a model based on functional connectivity.
Article
Neurosciences
Jiaxu Han, Sarah Keedy, Harriet de Wit
Summary: Individual differences in subjective, stimulant-like effects of alcohol are associated with the risk of developing alcohol use disorder.
Article
Neurosciences
Jeffrey M. Kenzie, Deepthi Rajashekar, Bradley G. Goodyear, Sean P. Dukelow
Summary: Around 50% of stroke patients have deficits in proprioception, but our understanding of the neurological mechanisms behind these deficits is limited. This study used resting-state functional magnetic resonance imaging (fMRI) to investigate changes in functional brain networks associated with proprioception deficits in stroke patients. The results showed reduced connectivity in specific brain regions, including the supplementary motor area and the supramarginal gyrus, in stroke patients compared to healthy controls. Functional connectivity of these regions, as well as the primary somatosensory cortex and the parietal opercular area, was significantly associated with proprioceptive function. The parietal lobe of the lesioned hemisphere was identified as an important node for proprioception after stroke, and evaluating the functional connectivity of this region could help predict recovery. The study also identified potential targets for therapeutic neurostimulation to aid in stroke recovery.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Atsushi Fujimoto, Catherine Elorette, J. Megan Fredericks, Satoka H. Fujimoto, Lazar Fleysher, Peter H. Rudebeck, Brian E. Russ
Summary: This study used noninvasive neuroimaging techniques to assess the impact of a drug on brain functional connectivity. The results showed that an appropriate dose of the drug did not alter brain connectivity, while an excess dose of the drug increased functional connectivity in the frontal regions and may cause deficits related to attention or motivation.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Guillaume Carey, Meltem Gormezoglu, Joost J. A. de Jong, Paul A. M. Hofman, Walter H. Backes, Kathy Dujardin, AlbertF G. Leentjens
Summary: Anxiety symptoms in Parkinson's disease are associated with structural and functional changes in the fear and limbic cortico-striato-thalamocortical circuits. The neuropathology of PD may affect these circuits in different ways, which explains the high prevalence of anxiety and associated symptoms in PD.
MOVEMENT DISORDERS
(2021)
Letter
Medicine, Research & Experimental
Tim A. M. Bouwens van der Vlis, Annelien A. Duits
Review
Medicine, Research & Experimental
Tim A. M. Bouwens van Der Vlis, Annelien Duits, Megan M. G. H. van de Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens
Summary: Deep brain stimulation (DBS) is an effective treatment for refractory obsessive-compulsive disorder (OCD) and neuropsychological assessment plays a crucial role in monitoring the cognitive safety of the treatment. This systematic review found variable cognitive outcomes following DBS for OCD, particularly in domains such as attention, memory, and executive functioning. Further research is needed to better understand the cognitive safety and working mechanisms of DBS for OCD.
Article
Clinical Neurology
Quentin Devignes, Cecile Bordier, Romain Viard, Luc Defebvre, Gregory Kuchcinski, Albert F. G. Leentjens, Renaud Lopes, Kathy Dujardin
Summary: The dual syndrome hypothesis in mild cognitive impairment (MCI) in Parkinson's disease distinguishes between frontostriatal and posterior cortical subtypes, and this study found specific changes in resting-state functional connectivity associated with these subtypes. Patients with posterior cortical deficits showed increased functional connectivity within the basal ganglia network, while patients with frontostriatal deficits showed reduced inter-network connectivity compared to healthy controls and patients with normal cognition or a posterior cortical subtype.
MOVEMENT DISORDERS
(2022)
Article
Medicine, Research & Experimental
Tim A. M. Bouwens van der Vlis, Megan M. G. H. van de Veerdonk, Linda Ackermans, Albert F. G. Leentjens, Marcus L. F. Janssen, Mark L. Kuijf, Koen R. J. Schruers, Annelien Duits, Felix Gubler, Pieter Kubben, Yasin Temel
Summary: This study retrospectively analyzed adverse events (AEs) of deep brain stimulation (DBS) procedures and found that surgical site infections and wire tethering were the most common AEs. However, major AEs requiring aggressive treatment were rare. A uniform reporting system for surgical and hardware-related AEs in DBS surgery would be useful.
Article
Clinical Neurology
Nacim Betrouni, Edouard Alazard, Madli Bayot, Guillaume Carey, Philippe Derambure, Luc Defebvre, Albert Fg Leentjens, Arnaud Delval, Kathy Dujardin
Summary: Through high density electroencephalography (hd-EEG) recordings and comparisons in 108 Parkinson's disease patients, it was found that patients with anxiety symptoms had lower relative power in the alpha1 frequency band in the right prefrontal cortex, and showed different characteristics in functional connectivity compared to those without anxiety.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Critical Care Medicine
Pauline van Gils, Caroline van Heugten, Jeannette Hofmeijer, Hanneke Keijzer, Sjoukje Nutma, Annelien Duits
Summary: This study examines the diagnostic value of the Montreal Cognitive Assessment (MoCA) in patients after out-of-hospital cardiac arrest (OHCA). The results show that the MoCA has good sensitivity and adequate specificity in identifying cognitive impairment, with a high negative predictive value.
Article
Behavioral Sciences
Nacim Betrouni, Quentin Devignes, Madli Bayot, Philippe Derambure, Luc Defebvre, Albert FG. Leentjens, Arnaud Delval, Kathy Dujardin
Summary: This study investigates EEG modifications associated with mild cognitive impairment in Parkinson's disease (PD-MCI) subtypes. The results show that patients with a frontostriatal subtype exhibit spectral and functional EEG alterations, while the posterior cortical subtype does not differ significantly from the normal cognition group. This study provides evidence for the dual syndrome hypothesis and highlights the importance of identifying PD-MCI subtypes.
Article
Neurosciences
Quentin Devignes, Sami Daoudi, Romain Viard, Renaud Lopes, Nacim Betrouni, Gregory Kuchcinski, Anne-Sophie Rolland, Caroline Moreau, Luc Defebvre, Eric Bardinet, Marie Bonnet, Christine Brefel-Courbon, Christine Delmaire, Fouzia El Mountassir, Frederique Fluchere, Anne Fradet, Caroline Giordana, Elodie Hainque, Jean-Francois Houvenaghel, Bechir Jarraya, Helene Klinger, David Maltete, Ana Marques, Mylene Meyer, Olivier Rascol, Tiphaine Rouaud, Melissa Tir, Thomas Wirth, Jean-Christophe Corvol, David Devos, Kathy Dujardin
Summary: The study found that a significant proportion of candidates for subthalamic deep brain stimulation (STN-DBS) have Parkinson's disease mild cognitive impairment (PD-MCI), which is associated with cortical and subcortical alterations. Among the PD-MCI subtypes, patients with posterior cortical deficits (PD-PC) had lower global efficiency and worse performance on visuospatial functions, episodic memory, and language, suggesting a higher risk of dementia. There were no significant differences between the PD-MCI subtypes.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Psychology, Clinical
Charlotte Manceau, Emilie Constant, Elodie Brugalle, Emilie Wawrziczny, Celine Sokolowski, Berengere Flinois, Guillaume Baille, Luc Defebvre, Kathy Dujardin, Pascal Antoine
Summary: This qualitative study aims to understand the experience and functioning of couples during the honeymoon period of Parkinson's disease. The results highlight different dynamics between couples, with some adjusting flexibly and positively while others oscillate between rigid hyperprotection and control/avoidance.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Clinical Neurology
Amee F. Wolters, Stijn Michielse, Mark L. Kuijf, Luc Defebvre, Renaud Lopes, Kathy Dujardin, Albert F. G. Leentjens
Summary: This study compared cognitive and brain network connectivity differences between different subtypes of Parkinson's disease. While the PIGD subtype performed worse in cognitive domains compared to the TD subtype, there were no significant differences in brain network connectivity between the two subtypes.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Neurosciences
Joshua Harvey, Rick A. Reijnders, Rachel Cavill, Annelien Duits, Sebastian Kohler, Lars Eijssen, Bart P. F. Rutten, Gemma Shireby, Ali Torkamani, Byron Creese, Albert F. G. Leentjens, Katie Lunnon, Ehsan Pishva
Summary: This study aimed to predict cognitive outcomes in Parkinson's disease patients using machine learning models. The research found that clinical variables performed best in predicting cognitive impairment outcomes, and including biofluid and genetic/epigenetic variables slightly improved prediction performance.
NPJ PARKINSONS DISEASE
(2022)
Article
Psychology
Annelien A. Duits, Eva M. de Ronde, R. Saman Vinke, Sandra H. Vos, Rianne A. J. Esselink, Roy P. C. Kessels
Summary: Deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease may not affect facial emotion recognition 1 year after surgery, according to a study of 59 patients with pre- and postoperative assessments. However, it does not rule out the potential impact of facial emotion recognition on the outcome of the surgery.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
Article
Geriatrics & Gerontology
Maud M. J. Daemen, Lizzy M. M. Boots, Mayke Oosterloo, Marjolein E. de Vugt, Annelien A. Duits
Summary: This study aims to provide insight into the challenges and facilitators HD caregivers face and their needs for a remote support program. The study found that caregivers face a paradox between self-care and caring for others, and challenges such as lack of HD awareness, taboo and shame, loneliness, concerns about heredity and children, and coping with HD symptoms. The study also identified facilitators such as social networks, professional support, openness, early communication, and daily structure. The findings will be used to develop a blended and self-management remote support program to empower caregivers.
AGING & MENTAL HEALTH
(2023)
Meeting Abstract
Clinical Neurology
Maud Daemen, Lizzy Boots, Annelien Duits, Mayke Oosterloo, Marjolein de Vugt
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
