Article
Medicine, General & Internal
Sryla Punjadath, Mukul Aggarwal, Gaurav Gupta, Upendra Baitha
Summary: A man in his early 30s presented with progressive shortness of breath and a history of deep vein thrombosis 5 years ago. Further investigations revealed chronic thromboembolic pulmonary hypertension and primary antiphospholipid syndrome. After undergoing pulmonary endarterectomy, the patient's symptoms were relieved and he was started on lifelong oral anticoagulation with warfarin. The importance of appropriate workup for venous thrombosis and the impact of socioeconomic factors on diagnosis delay were emphasized.
Article
Medicine, General & Internal
Riley G. Jones, Brittany Hoyes, Jaymin Patel, Muhammad Omer Zaman
Summary: Adult-onset Still's disease (AOSD) is a rare inflammatory disorder with limited understanding of its pathophysiology. This report highlights the importance of a judicious approach to anticoagulation selection in patients with deep venous thromboses associated with active AOSD, especially given the clinical similarities with COVID-19.
Article
Medicine, General & Internal
Kesar Prajapati, Vikranti Sailor, Savan Patel, Malay Rathod
Summary: This case underscores the connection between pernicious anemia, vitamin B-12 deficiency, and hyperhomocysteinemia leading to recurrent cerebral venous thrombosis (CVT). The patient was cured with vitamin B-12 and anticoagulation therapy, emphasizing the importance of investigating levels of vitamin B-12 and homocysteine in CVT cases.
Article
Medicine, General & Internal
Celina Ledgard, James Clarke, Gerald Thomas McGreal
Summary: This report describes a unique case of a healthy man in his 30s, presenting with progressive unilateral leg swelling and no identified common risk factors. Further investigations revealed a rare congenital anomaly of hypoplasia of the renal Inferior Vena Cava (IVC). Successful treatment involved intravenous unfractionated heparin infusion and lifelong anticoagulation.
Article
Medicine, General & Internal
Nishant Aggarwal, Dana Rector, Nicholas Lazar, Florian Bukovec
Summary: This is a rare case of paradoxical thromboembolism that presented with abdominal pain, watery stools, and exertional dyspnea. The pain eventually migrated to the left flank and was diagnosed as renal infarct with renal artery thrombosis. The patient was also found to have a patent foramen ovale. This case highlights the importance of a high index of clinical suspicion and further investigation in cases of simultaneous arterial and venous thrombosis.
Article
Medicine, General & Internal
Heena Tabassum, Sumit Aggarwal, Geetha R. Menon, Narendra Arora, Sagnik Chakraborty, M. Rao, Balram Bhargava, Nabendu S. Chatterjee
Summary: The Indian Council of Medical Research (ICMR) in New Delhi has established a nationwide registry called the 'Indian Registry for Venous Thromboembolism Disorder (i-RegVeD)' to analyze real-time sociodemographic profile, disease patterns, management strategies, treatment choices, and outcomes of patients with venous thromboembolism (VTE) in order to gather evidence and fill knowledge gaps about the disease across different demographic regions. This hospital-based registry will collect data on VTE occurrence and characteristics from 16 hospital sites throughout India and the results will be disseminated publicly on a study website as well as through scientific meetings and publications.
Article
Medicine, General & Internal
Tamadher Al Barhi, Yasser Wali, Sareyah Al Sibai, Zainab Al Balushi
Summary: Sickle cell disease is a common haematological disorder in Oman, and splenectomy can improve the quality of life for patients. However, a rare complication of this procedure is porto-splenic vein thrombosis. We report a successful case of treating extensive porto-splenic vein thrombosis with early initiation of anticoagulation.
Article
Medicine, General & Internal
Ahmad Abulawi, Ali Al-Tarbsheh, Omar Tageldin, Batool Asra
Summary: This article presents the first documented case of acute portal venous thrombosis associated with acute hepatitis A virus infection in a previously healthy male. The study explores the possible pathophysiology, work-up, and treatment strategies for this condition. The authors recommend routine screening for hepatitis A serological markers in the investigation of acute portal venous thrombosis of unknown etiology, particularly in unvaccinated patients with recent HAV exposure risk factors.
Article
Medicine, General & Internal
Juehea Lee, Graham Roche-Nagle
Summary: An 85-year-old man with a known history of abdominal aortic aneurysm presented with a swollen, tender and erythematous left leg. CT angiogram revealed a proximal deep vein thrombosis and a permanent IVC filter penetrating his AAA. Treatment included apixaban and close observation due to patient's age and comorbidities, highlighting unique considerations in managing permanent IVC filter complications in AAA patients.
Article
Medicine, General & Internal
Henrietta Afari, Leben Tefera, Rachel P. Rosovsky
Summary: This case highlights a rare occurrence of venous and arterial thrombi in a severe COVID-19 patient, suggesting the potential of COVID-19 to trigger thrombosis and the need for further research on its coagulation mechanism and treatment options.
Article
Medicine, General & Internal
Purva Sharma, Kanishka Chakraborty
Summary: COVID-19 infection can lead to systemic coagulopathy and acute thromboembolic complications, even with the risk of occurrence during anticoagulation treatment.
Article
Medicine, General & Internal
Samer Alkassis, Nathan Zaher, Zaid Kaloti, Diane Levine
Summary: Acute portal vein thrombosis is a rare disorder that can be caused by prothrombotic states; it is crucial to determine the underlying cause and provide appropriate treatment.
Article
Genetics & Heredity
Aude-Anais Olijnik, Noemi B. A. Roy, Caroline Scott, Joseph A. Marsh, Jill Brown, Karin Lauschke, Katrine Ask, Nigel Roberts, Damien J. Downes, Sanja Brolih, Errin Johnson, Barbara Xella, Melanie Proven, Ria Hipkiss, Kate Ryan, Per Frisk, Johan Makk, Eva-Lena Maria Stattin, Nandini Sadasivam, Louisa McIlwaine, Quentin A. Hill, Raffaele Renella, Jim R. Hughes, Richard J. Gibbons, Anja Groth, Peter J. McHugh, Douglas R. Higgs, Veronica J. Buckle, Christian Babbs
Summary: The study identified novel pathogenic variants in CDA-I patients, revealing genetic heterogeneity in the disease. The findings suggest that C15orf41 may be the key determinant of CDA-I, offering new insights into the disease mechanism.
JOURNAL OF MEDICAL GENETICS
(2021)
Article
Medicine, General & Internal
Antonios Revythis, Stergios Boussios, Vijayakumar Ganesh, Rahuldeb Sarkar
Summary: This article presents a case of a rare cerebral venous thrombosis in a patient with nephrotic syndrome, which occurred years after the initial diagnosis. The patient's perspective is also highlighted, as he experienced a complication after over two decades of living with the condition. A literature search revealed limited research on cerebral venous thrombosis in adults with nephrotic syndrome.
Article
Medicine, General & Internal
Roha Ahmad Choudhary, M. A. Rehman Siddiqui, Bushra Moiz, Saliha Ishaq
Summary: This is a rare case in which a patient presented with combined central retinal artery and vein occlusion associated with antiphospholipid syndrome. Accurate evaluation of patients with retinal vascular occlusions is important to prevent missed diagnosis of antiphospholipid syndrome and recurrent and more devastating vascular events.
