Article
Pharmacology & Pharmacy
Saleh A. Almatroodi, Abdullah M. Alnuqaydan, Ali Yousif Babiker, Mashael Abdullah Almogbel, Amjad Ali Khan, Arshad Husain Rahmani
Summary: The study demonstrates that 6-gingerol has a significant role in ameliorating renal injury in STZ-induced diabetic rats by reducing blood glucose, improving lipid profile, and enhancing antioxidant enzyme levels.
Article
Pharmacology & Pharmacy
Anna Li, Man Zhao, Zexin Yang, Zhenya Fang, Weiyi Qi, Changqing Zhang, Meijuan Zhou, Junjun Guo, Shuxian Li, Xietong Wang, Meihua Zhang
Summary: The protective effect of 6-Gingerol against placental injury in preeclampsia was demonstrated through reducing oxidative stress and inhibiting excessive mitophagy caused by mitochondrial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Venkata Subbaiah Ganjikunta, Ramana Reddy Maddula, Shanmugam Bhasha, Ravi Sahukari, Shanmugam Kondeti Ramudu, Venkatrayulu Chenji, Sathyavelu Reddy Kesireddy, Zhe Zheng, Mallikarjuna Korivi
Summary: This study investigated the cardioprotective properties of 6-gingerol against alcohol-induced cardiac tissue damage. The results showed that 6-gingerol suppressed ROS production, reversed oxidative modification of DNA and proteins, and restored antioxidant enzyme activities. It also reduced elevated cardiac biomarkers and apoptosis. Transmission electron microscope images confirmed the cardioprotective properties of 6-gingerol.
Article
Agriculture, Dairy & Animal Science
Wenjie Yu, Yanxia Peng, Xinyue Peng, Ze Li, Chang Liu, Liu Yang, Yan Gao, Shuang Liang, Bao Yuan, Chengzhen Chen, Nam-hyung Kim, Hao Jiang, Jiabao Zhang
Summary: Adding 6-gingerol to in vitro culture system can improve the anti-oxidation capacity of early embryos, enhance embryo development, and increase the blastocyst formation rates.
Article
Food Science & Technology
Robin Mesnage, Scarlett Ferguson, Inger Brandsma, Nynke Moelijker, Gaonan Zhang, Francesca Mazzacuva, Anna Caldwell, John Halket, Michael N. Antoniou
Summary: The co-formulant POE-15 tallow amine (POE-15) and the active ingredient glyphosate in herbicides have been found to be cytotoxic, causing cell necrosis and oxidative stress. The study highlights the importance of comprehensive testing of both co-formulants and active ingredients of commercial pesticides to ensure better regulation and protection of public health and the environment.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Iwona Bukowska-Osko, Dorota Sulejczak, Katarzyna Kaczynska, Patrycja Kleczkowska, Karol Kramkowski, Marta Popiel, Ewa Wietrak, Pawel Kowalczyk
Summary: Structural abnormalities can cause DNA modifications, leading to various diseases including cancer. Cells defend and repair damaged genetic material through lactoferrin, an endogenous protein with antibacterial, antiviral, antifungal, and anticancer properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xue Han, Yakun Yang, Muqing Zhang, Xi Chu, Bin Zheng, Chenxu Liu, Yucong Xue, Shengjiang Guan, Shijiang Sun, Qingzhong Jia
Summary: The study found that 6G effectively counteracts As2O3-induced cardiotoxicity, including oxidative stress, inflammation, and apoptosis. This may be attributed to its activation action on the AMPK/SIRT1/PGC-1 alpha signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Neil B. Metcalfe, Mats Olsson
Summary: This review highlights the dynamic processes of ROS production, telomeric DNA damage, and DNA repair, emphasizing the trade-off between energetic efficiency and telomere protection. Mitochondrial features and ATP production efficiency play crucial roles in maintaining DNA integrity and telomere dynamics, with implications for individual variation and adaptation to changing environmental contexts.
Article
Biotechnology & Applied Microbiology
Nan Tao, Wenrui Zhang, Liang Si, Runqiang Zhang, Dan Wang, Changhong Guo
Summary: Aniline has significant growth, oxidative, and genetic toxic effects on rice. Yunxian 510 is more sensitive to aniline poisoning than Mudanjiang 25.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Biochemistry & Molecular Biology
Feifei Zhao, Sara Whiting, Sarah Lambourne, R. John Aitken, Ying-pu Sun
Summary: The study demonstrates that melatonin can protect human sperm from heat-induced oxidative stress by suppressing sperm mitochondrial ROS generation, increasing mitochondrial membrane potential, reducing lipid peroxidation product 4-HNE formation, and decreasing sperm DNA damage and apoptosis. This suggests melatonin as a potential treatment option for male infertility caused by heat-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Michel Fasnacht, Norbert Polacek
Summary: Since the great oxidation event, Earth's cellular life forms have had to deal with reactive oxygen species (ROS) affecting biomolecules and cellular metabolism. Increased ROS levels in the biosphere represent growing stress and shape species evolution. Systems have evolved to remove ROS and repair damage, but oxidative stress occurs if ROS surpass the cell's capacity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Aracelly Gaete-Argel, Felipe Velasquez, Chantal L. Marquez, Barbara Rojas-Araya, Constanza Bueno-Nieto, Josefina Marin-Rojas, Miguel Cuevas-Zuniga, Ricardo Soto-Rifo, Fernando Valiente-Echeverria
Summary: Tellurium oxyanion, tellurite, is a highly toxic compound that has been increasingly present in the environment due to industrial processes, and is associated with adverse effects on human health. Research shows that tellurite can induce the assembly of stress granules (SGs) in cells, both in the cytoplasm and nucleus. The presence of tellurite-induced nuclear SGs correlates with DNA damage, revealing a new aspect of cellular stress response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Toxicology
Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Guo
Summary: The cardiotoxicity of MEHP is mediated by reduced cell viability, mitochondrial dysfunction, oxidative stress, and apoptosis in cardiomyocytes. FOXO3a plays a critical role in defending against MEHP-induced oxidative stress and apoptosis by upregulating the expression of Mn-SOD and ARC.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emily Ho, Carmen P. Wong, Janet C. King
Summary: Dr. Bruce Ames pioneered the understanding of oxidative stress, DNA damage, and the connection between micronutrient deficiencies and DNA damage. Zinc is essential for human health, playing a critical role in cellular antioxidant defense, DNA integrity, and immune function. Studies have shown that zinc deficiency is associated with oxidative stress, susceptibility to DNA damage, and chronic inflammation, emphasizing the importance of adequate nutrition for healthy aging.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zhaoyang Wang, Ziyi Li, Yaling Lei, Yuan Liu, Yuqing Feng, Derong Chen, Siying Ma, Ziyan Xiao, Meirong Hu, Jingxian Deng, Yuxin Wang, Qihao Zhang, Yadong Huang, Yan Yang
Summary: In this study, a recombinant photolyase-thymine (rPHO) from Thermus thermophilus was found to efficiently repair UVB-induced DNA photoproducts and exhibit promising protective effects against photoaging and skin carcinogenesis.
